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ERP44 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246068

TXNDC4/ERp44/KIAA0573 was identified via its interaction with Erol-Lalpha, which in turn has been shown to regulate oxidative protein folding by selectively oxidizing protein disulfide isomerase. TXNDC4 is induced during ER stress and forms mixed disulfides… More details

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Testing Data View PDF
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Technical Datasheet View PDF
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Product Overview

Product Name
ERP44, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 3C7] (IgG2b,k) to Human ERP44
Product Gene Name
anti-ERP44 antibody
Product Synonym Names
Anti-ERP44 Antibody (clone 3C7) IHC-plus; ERP44; ER protein 44; PDIA10; TXNDC4; KIAA0573; Human ERP44
Clonality
Monoclonal
Isotype
IgG2b,k
Clone Number
3C7
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.2. Sourced in Ascites.
Purity/Purification
Protein A Purified
Concentration
0.44 mg/ml (lot specific)
Specificity
Human TXNDC4
Preparation and Storage
Store at -20 degree C or lower. Aliquot to avoid repeated freezing and thawing.
Molecular Weight
46,971 Da
OMIM
609170
3D Structure
ModBase 3D Structure for Q9BS26
Target Species
Human
Immunogen Description
TXNDC4 (AAH05374, 30 a.a. ~ 407 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen
ERP44 antibody was raised against tXNDC4 (AAH05374, 30 a.a. ~ 407 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Applications Tested/Suitable for anti-ERP44 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), Immunoprecipitation (IP), ELISA (EIA)
Application Notes for anti-ERP44 antibody
ELISA, IHC-P (3 - 5 ug/ml), IP, WB (1:500 - 1:1000)
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Western Blot using transfected cell lysates, cell line lysates and the recombinant protein used as the immunogen.

Immunohistochemistry (IHC) of anti-ERP44 antibody

Anti-ERP44 / TXNDC4 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.
Mouse Anti-ERP44 Monoclonal Antibody – Cat# MBS246068

Immunohistochemistry (IHC) of anti-ERP44 antibody

Anti-ERP44 / TXNDC4 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.
Mouse Anti-ERP44 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246068

Western Blot (WB) of anti-ERP44 antibody

Antibody Western blot of TXNDC4 expression in K-562.
Mouse Anti-ERP44 Monoclonal Antibody, Western Blot (WB) – Cat# MBS246068

Western Blot (WB) of anti-ERP44 antibody

Antibody, Western blot of TXNDC4 expression in A-431.
Mouse Anti-ERP44 Monoclonal Antibody, Western Blot (WB) – Cat# MBS246068

ELISA (EIA) of anti-ERP44 antibody

Detection limit for recombinant GST tagged TXNDC4 is 1 ng/ml as a capture antibody.
Mouse Anti-ERP44 Monoclonal Antibody, ELISA (EIA) – Cat# MBS246068

Other Notes

Small volumes of anti-ERP44 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ERP44 purchase

MBS246068 is an antibody targeting ERP44. Also known as Mouse Monoclonal [clone 3C7] (IgG2b,k) to Human ERP44. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for ERP44. It may not necessarily be applicable to this product.

NCBI GI #
52487191
NCBI GeneID
23071
NCBI Accession #
NP_055866.1
UniProt Primary Accession #
Q9BS26
UniProt Secondary Accession #
O60319; Q4VXC1; Q5VWZ7; Q6UW14; Q8WX67
UniProt Related Accession #
Q9BS26
GenBank Nucleotide #
NM_015051.1
NCBI Official Full Name
endoplasmic reticulum resident protein 44
NCBI Official Synonym Full Names
endoplasmic reticulum protein 44
NCBI Official Symbol
ERP44
NCBI Official Synonym Symbols
PDIA10; TXNDC4
UniProt Protein Name
Endoplasmic reticulum resident protein 44
UniProt Synonym Protein Names
Thioredoxin domain-containing protein 4
Protein Family
Endoplasmic reticulum resident protein
UniProt Gene Name
ERP44
UniProt Synonym Gene Names
KIAA0573; TXNDC4; ER protein 44; ERp44
UniProt Entry Name
ERP44_HUMAN
NCBI Protein Information
endoplasmic reticulum resident protein 44; ER protein 44; thioredoxin domain-containing protein 4; endoplasmic reticulum resident protein 44 kDa; protein disulfide isomerase family A, member 10; thioredoxin domain containing 4 (endoplasmic reticulum)

UniProt Comments for ERP44

ERP44: Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum. Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates. Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration. By endoplasmic reticulum stress.

Protein type: Secreted, signal peptide; Secreted; Endoplasmic reticulum; Isomerase

Chromosomal Location of Human Ortholog: 9q31.1

Cellular Component: endoplasmic reticulum membrane; cell surface; endoplasmic reticulum lumen; ER-Golgi intermediate compartment

Molecular Function: protein binding; protein disulfide isomerase activity

Biological Process: glycoprotein metabolic process; protein folding; cell redox homeostasis; response to unfolded protein
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Research Articles on ERP44

1. Data indicate that protein disulfide isomerase (PDI) and ERp44 dynamically localize Ero1alpha and peroxiredoxin 4 in early secretory compartment (ESC).

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-ERP44 antibody

 Reference Product  PubMed Publications
 ERO1L antibody  >11 publications with ERP44 and ERO1L
 PPARG antibody  >6 publications with ERP44 and PPARG
 ITPR1 antibody  >2 publications with ERP44 and ITPR1
 LMAN1 antibody  >2 publications with ERP44 and LMAN1
 ERO1LB antibody  >1 publications with ERP44 and ERO1LB
 SLC6A4 antibody  >1 publications with ERP44 and SLC6A4

Diseases associated with anti-ERP44 antibody

 Disease Name  Pubmed Publications
 Insulin Resistance Antibodies  >3 publications with ERP44 and Insulin Resistance
 Inflammation Antibodies  >2 publications with ERP44 and Inflammation
 Atherosclerosis Antibodies  >1 publications with ERP44 and Atherosclerosis
 Nervous System Diseases Antibodies  >1 publications with ERP44 and Nervous System Diseases
 Cardiovascular Diseases Antibodies  >1 publications with ERP44 and Cardiovascular Diseases
 Necrosis Antibodies  >1 publications with ERP44 and Necrosis

Organs/Tissues associated with anti-ERP44 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >6 publications with ERP44 and Blood
 Heart Antibodies  >4 publications with ERP44 and Heart
 Pancreas Antibodies  >3 publications with ERP44 and Pancreas
 Brain Antibodies  >3 publications with ERP44 and Brain
 Muscle Antibodies  >2 publications with ERP44 and Muscle
 Connective Tissue Antibodies  >2 publications with ERP44 and Connective Tissue
 Skin Antibodies  >1 publications with ERP44 and Skin
 Kidney Antibodies  >1 publications with ERP44 and Kidney
 Embryonic Tissue Antibodies  >1 publications with ERP44 and Embryonic Tissue
 Placenta Antibodies  >1 publications with ERP44 and Placenta
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