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YY1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246160

YY1 is a ubiquitously distributed transcription factor belonging to the GLI-Kruppel class of zinc finger proteins. The protein is involved in repressing and activating a diverse number of promoters. YY1 may direct histone deacetylases and histone… More details

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Product Overview

Product Name
YY1, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 2C4] (IgG1,k) to Human YY1
Product Gene Name
anti-YY1 antibody
Product Synonym Names
Anti-YY1 Antibody (clone 2C4) IHC-plus; YY1; Delta transcription factor; INO80S; NF-E1; INO80 complex subunit S; YY1 transcription factor; YIN-YANG-1; YY-1; Yin and yang 1; UCRBP; Yin and Yang 1 protein; Human YY1
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
2C4
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.4.
Purity/Purification
Protein A Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human YY1
Preparation and Storage
For long term storage -20 degree C is recommended.
Molecular Weight
44,713 Da
OMIM
600013
3D Structure
ModBase 3D Structure for P25490
Target Species
Human
Immunogen Description
YY1 (NP_003394, 221 a.a. ~ 321 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen
YY1 antibody was raised against yY1 (NP_003394, 221 a.a. ~ 321 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Applications Tested/Suitable for anti-YY1 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-YY1 antibody
ELISA, IF (10 ug/ml), IHC-P (5 ug/ml), WB
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Western Blot using transfected cell lysates, cell line lysates and the recombinant protein used as the immunogen.

Immunohistochemistry (IHC) of anti-YY1 antibody

Anti-YY1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-YY1 Monoclonal Antibody – Cat# MBS246160

Immunofluorescence (IF) of anti-YY1 antibody

Immunofluorescence of monoclonal antibody to YY1 on HeLa cell. [antibody concentration 10 ug/ml]
Mouse Anti-YY1 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS246160

Western Blot (WB) of anti-YY1 antibody

YY1 monoclonal antibody clone 2C4 Western blot of YY1 expression in HeLa NE.
Mouse Anti-YY1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS246160

ELISA (EIA) of anti-YY1 antibody

Detection limit for recombinant GST tagged YY1 is approximately 0.03 ng/ml as a capture antibody.
Mouse Anti-YY1 Monoclonal Antibody, ELISA (EIA) – Cat# MBS246160

Other Notes

Small volumes of anti-YY1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for YY1 purchase

MBS246160 is an antibody targeting YY1. Also known as Mouse Monoclonal [clone 2C4] (IgG1,k) to Human YY1. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for YY1. It may not necessarily be applicable to this product.

NCBI GI #
4507955
NCBI GeneID
7528
NCBI Accession #
NP_003394.1
UniProt Primary Accession #
P25490
UniProt Secondary Accession #
Q14935
UniProt Related Accession #
P25490
GenBank Nucleotide #
NM_003403.4
NCBI Official Full Name
transcriptional repressor protein YY1
NCBI Official Synonym Full Names
YY1 transcription factor
NCBI Official Symbol
YY1
NCBI Official Synonym Symbols
DELTA; NF-E1; UCRBP; INO80S; YIN-YANG-1
UniProt Protein Name
Transcriptional repressor protein YY1
UniProt Synonym Protein Names
Delta transcription factor; INO80 complex subunit S; NF-E1; Yin and yang 1; YY-1
Protein Family
Transcriptional repressor protein
UniProt Gene Name
YY1
UniProt Synonym Gene Names
INO80S; YY-1
UniProt Entry Name
TYY1_HUMAN
NCBI Protein Information
transcriptional repressor protein YY1; YY-1; Yin and Yang 1 protein; INO80 complex subunit S; delta transcription factor

UniProt Comments for YY1

YY1: a polycomb-group (Pc-G) protein essential for early mammalian development and the regulation of X-inactivation and certain imprinted genes. Required for the transactivation of TSIX by CTCF. The complex of CTCF-YY1-TSIX is a critical regulator of the X chromosome binary switch. Can function as an activator or a repressor depending on the presence of other proteins. For example it acts as a repressor in absence of adenovirus E1A protein but as an activator in its presence.

Protein type: C2H2-type zinc finger protein; Cell development/differentiation; Transcription factor

Chromosomal Location of Human Ortholog: 14q

Cellular Component: transcription factor complex; nuclear matrix; PcG protein complex; nucleus

Molecular Function: protein binding; DNA binding; four-way junction DNA binding; zinc ion binding; RNA binding; transcription coactivator activity; SMAD binding; transcription factor activity; transcription corepressor activity

Biological Process: regulation of transcription from RNA polymerase II promoter; anterior/posterior pattern formation; RNA localization; camera-type eye morphogenesis; transcription, DNA-dependent; spermatogenesis; negative regulation of transcription from RNA polymerase II promoter; cell differentiation; response to DNA damage stimulus; chromosome organization and biogenesis; response to UV-C; double-strand break repair via homologous recombination
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Research Articles on YY1

1. these findings suggest that YY1-RuvBL1-RuvBL2 complexes could contribute to functions beyond transcription, and we show that YY1 and the ATPase activity of RuvBL2 are required for RAD51 foci formation during homologous recombination.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-YY1 antibody

 Reference Product  PubMed Publications
 SP1 antibody  >124 publications with YY1 and SP1
 RYBP antibody  >18 publications with YY1 and RYBP
 HDAC1 antibody  >18 publications with YY1 and HDAC1
 HDAC2 antibody  >13 publications with YY1 and HDAC2
 HDAC3 antibody  >11 publications with YY1 and HDAC3
 TP53 antibody  >8 publications with YY1 and TP53
 TFCP2 antibody  >7 publications with YY1 and TFCP2
 INO80 antibody  >6 publications with YY1 and INO80
 EP300 antibody  >4 publications with YY1 and EP300
 RUVBL2 antibody  >1 publications with YY1 and RUVBL2

Pathways associated with anti-YY1 antibody

 Products by Pathway  Pathway Diagram
 Delta-Notch Signaling Pathway antibodies  Delta-Notch Signaling Pathway Diagram
 E2F Transcription Factor Network Pathway antibodies  E2F Transcription Factor Network Pathway Diagram
 Notch Signaling Pathway antibodies  Notch Signaling Pathway Diagram
 Notch-mediated HES/HEY Network Pathway antibodies  Notch-mediated HES/HEY Network Pathway Diagram
 SREBP Signalling Pathway antibodies  SREBP Signalling Pathway Diagram
 Signaling Events Mediated By HDAC Class I Pathway antibodies  Signaling Events Mediated By HDAC Class I Pathway Diagram
 MTOR Signaling Pathway antibodies  MTOR Signaling Pathway Diagram
 P53 Pathway antibodies  P53 Pathway Diagram

Diseases associated with anti-YY1 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >39 publications with YY1 and Nervous System Diseases
 Cell Transformation, Neoplastic Antibodies  >27 publications with YY1 and Cell Transformation, Neoplastic
 Necrosis Antibodies  >24 publications with YY1 and Necrosis
 Liver Diseases Antibodies  >23 publications with YY1 and Liver Diseases
 Disease Progression Antibodies  >23 publications with YY1 and Disease Progression
 Cardiovascular Diseases Antibodies  >22 publications with YY1 and Cardiovascular Diseases
 Inflammation Antibodies  >19 publications with YY1 and Inflammation
 Uterine Cervical Neoplasms Antibodies  >19 publications with YY1 and Uterine Cervical Neoplasms
 Liver Neoplasms Antibodies  >15 publications with YY1 and Liver Neoplasms
 Neoplasm Metastasis Antibodies  >14 publications with YY1 and Neoplasm Metastasis

Organs/Tissues associated with anti-YY1 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >119 publications with YY1 and Blood
 Muscle Antibodies  >94 publications with YY1 and Muscle
 Brain Antibodies  >67 publications with YY1 and Brain
 Liver Antibodies  >52 publications with YY1 and Liver
 Heart Antibodies  >48 publications with YY1 and Heart
 Lung Antibodies  >45 publications with YY1 and Lung
 Bone Antibodies  >41 publications with YY1 and Bone
 Vascular Antibodies  >40 publications with YY1 and Vascular
 Embryonic Tissue Antibodies  >38 publications with YY1 and Embryonic Tissue
 Kidney Antibodies  >29 publications with YY1 and Kidney
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