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CUX1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246172

MBS246172 is an antibody targeting CUX1. Also known as Mouse Monoclonal [clone 2A10] (IgG1,k) to Human CUX1 / CASP. Reactive in Human. Host: Mouse. More details

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Product Overview

Product Name
CUX1 / CASP, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 2A10] (IgG1,k) to Human CUX1 / CASP
Product Gene Name
anti-CUX1 antibody
Product Synonym Gene Name
CASP
Product Synonym Names
Anti-CUX1 / CASP Antibody (clone 2A10) IHC-plus; CUX1; CASP; CDP1; Clox; COY1; CUTL1; CCAAT displacement protein; Cut homolog; CUX; CUT; GOLIM6; Homeobox protein cux-1; p100; p200; p75; Protein CASP; CDP; Cut-like homeobox 1; Nbla10317; p110; Human CUX1; CASP
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
2A10
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.2. Sourced in Ascites.
Purity/Purification
Protein A Purified
Concentration
0.5 mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
Molecular Weight
75,644 Da
OMIM
116896
3D Structure
ModBase 3D Structure for Q13948
Target Species
Human
Immunogen Description
CUTL1 (AAH25422, 521 a.a. ~ 621 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen Type
Recombinant protein
Immunogen
CUX1 / CASP antibody was raised against cUTL1 (AAH25422, 521 a.a. ~ 621 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Applications Tested/Suitable for anti-CUX1 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-CUX1 antibody
ELISA, IF (10 ug/ml), IHC-P (5 ug/ml), WB
Usage: Immunofluorescence (10 ug/ml) - positive control HeLa cells. Sandwich ELISA (Recombinant protein).

Immunohistochemistry (IHC) of anti-CUX1 antibody

Anti-CUX1 / CUTL1 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-CUX1 Monoclonal Antibody – Cat# MBS246172

Immunohistochemistry (IHC) of anti-CUX1 antibody

Anti-CUX1 / CUTL1 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-CUX1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246172

Immunofluorescence (IF) of anti-CUX1 antibody

Immunofluorescence of monoclonal antibody to CUTL1 on HeLa cell (antibody concentration 10 ug/ml).
Mouse Anti-CUX1 Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS246172

Western Blot (WB) of anti-CUX1 antibody

Western blot of CUX1 expression in transfected 293T cell line by CUTL1 monoclonal antibody, clone 2A10. Lane 1: Transfected cell lysate Lane 2: Non-transfected lysate.
Mouse Anti-CUX1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS246172

ELISA (EIA) of anti-CUX1 antibody

Detection limit for recombinant GST tagged CUTL1 is approximately 0.03 ng/ml as a capture antibody.
Mouse Anti-CUX1 Monoclonal Antibody, ELISA (EIA) – Cat# MBS246172

Other Notes

Small volumes of anti-CUX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CUX1. It may not necessarily be applicable to this product.

NCBI GI #
31652236
NCBI GeneID
1523
NCBI Accession #
NP_001904.2
UniProt Primary Accession #
Q13948
UniProt Secondary Accession #
Q53GU9; Q8TBS3; B3KWH3; B3KWH8; B4DZZ2; G3V1Z6; J3KPQ6
UniProt Related Accession #
P39880; Q13948
GenBank Nucleotide #
NM_001913.4
NCBI Official Full Name
protein CASP isoform b
NCBI Official Synonym Full Names
cut-like homeobox 1
NCBI Official Symbol
CUX1
NCBI Official Synonym Symbols
CDP; CUX; p75; CASP; CDP1; COY1; Clox; p100; p110; p200; CUTL1; GOLIM6; CDP/Cut; Cux/CDP; Nbla10317
UniProt Protein Name
Protein CASP
Protein Family
Homeobox protein
UniProt Gene Name
CUX1
UniProt Synonym Gene Names
CUTL1
UniProt Entry Name
CASP_HUMAN
NCBI Protein Information
protein CASP; cut homolog; homeobox protein cux-1; CCAAT displacement protein; golgi integral membrane protein 6; putative protein product of Nbla10317

NCBI Summary for CUX1

The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]
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UniProt Comments for CUX1

CUTL1 iso1: Probably has a broad role in mammalian development as a repressor of developmentally regulated gene expression. May act by preventing binding of positively-activing CCAAT factors to promoters. Component of nf-munr repressor; binds to the matrix attachment regions (MARs) (5' and 3') of the immunoglobulin heavy chain enhancer. Represses T-cell receptor (TCR) beta enhancer function by binding to MARbeta, an ATC-rich DNA sequence located upstream of the TCR beta enhancer. Belongs to the CUT homeobox family. 8 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 7q22.1

Cellular Component: integral to Golgi membrane; cytosol; nucleus

Molecular Function: sequence-specific DNA binding; chromatin binding

Biological Process: regulation of transcription from RNA polymerase II promoter; intra-Golgi vesicle-mediated transport; transcription, DNA-dependent; multicellular organismal development; positive regulation of transcription from RNA polymerase II promoter; auditory receptor cell differentiation; negative regulation of transcription from RNA polymerase II promoter; positive regulation of dendrite morphogenesis; kidney development; lung development
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Research Articles on CUX1

1. Suggest that CUTL1 may regulate the proliferation of malignant melanoma by modulating the expression of cell cycle-related proteins.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CUX1 antibody

 Products by Pathway  Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 Signaling By FGFR In Disease Pathway antibodies  Signaling By FGFR In Disease Pathway Diagram
 Signaling By FGFR Mutants Pathway antibodies  Signaling By FGFR Mutants Pathway Diagram
 Signaling By FGFR1 Fusion Mutants Pathway antibodies  Signaling By FGFR1 Fusion Mutants Pathway Diagram
 Signaling By FGFR1 Mutants Pathway antibodies  Signaling By FGFR1 Mutants Pathway Diagram

Diseases associated with anti-CUX1 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >11 publications with CUX1 and Breast Neoplasms
 Disease Models, Animal Antibodies  >10 publications with CUX1 and Disease Models, Animal
 Kidney Diseases Antibodies  >9 publications with CUX1 and Kidney Diseases
 Death Antibodies  >8 publications with CUX1 and Death
 Nervous System Diseases Antibodies  >8 publications with CUX1 and Nervous System Diseases
 Uterine Neoplasms Antibodies  >7 publications with CUX1 and Uterine Neoplasms
 Carcinogenesis Antibodies  >6 publications with CUX1 and Carcinogenesis
 Inflammation Antibodies  >5 publications with CUX1 and Inflammation
 Adenocarcinoma Antibodies  >5 publications with CUX1 and Adenocarcinoma
 Necrosis Antibodies  >4 publications with CUX1 and Necrosis

Organs/Tissues associated with anti-CUX1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >28 publications with CUX1 and Brain
 Blood Antibodies  >19 publications with CUX1 and Blood
 Kidney Antibodies  >11 publications with CUX1 and Kidney
 Nerve Antibodies  >11 publications with CUX1 and Nerve
 Embryonic Tissue Antibodies  >10 publications with CUX1 and Embryonic Tissue
 Lung Antibodies  >7 publications with CUX1 and Lung
 Bone Antibodies  >5 publications with CUX1 and Bone
 Liver Antibodies  >5 publications with CUX1 and Liver
 Bone Marrow Antibodies  >3 publications with CUX1 and Bone Marrow
 Muscle Antibodies  >3 publications with CUX1 and Muscle
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