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CDKL1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246186

CDKL1 belongs to the CDKL subfamily. CDKL1 has been observed to be up-regulated in gliosis. Multiple isoforms have been identified due to alternative splicing. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CDKL1, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 2H6] (IgG2a,k) to Human CDKL1
Product Gene Name
Product Synonym Names
Anti-CDKL1 Antibody (clone 2H6) IHC-plus; CDKL1; CDC2-related kinase 1; KKIALRE; p42; Protein kinase p42 KKIALRE; Cyclin-dependent kinase-like 1; Human CDKL1
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
2H6
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.2
Purity/Purification
Protein A Purified
Preparation and Storage
Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
Molecular Weight
108,931 Da
OMIM
603441
3D Structure
ModBase 3D Structure for Q00532
Target Species
Human
Immunogen Description
CDKL1 (NP_004187, 259 a.a. ~ 358 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen Type
Recombinant protein
Immunogen
CDKL1 antibody was raised against cDKL1 (NP_004187, 259 a.a. ~ 358 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Applications Tested/Suitable for anti-CDKL1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-CDKL1 antibody
ELISA, IHC-P (5 ug/ml), WB
Usage: Western blot performed with the recombinant protein used as the immunogen as the protein source. Sandwich ELISA (Recombinant protein).

Immunohistochemistry (IHC) of anti-CDKL1 antibody

Anti-CDKL1 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-CDKL1 Monoclonal Antibody – Cat# MBS246186

Immunohistochemistry (IHC) of anti-CDKL1 antibody

Anti-CDKL1 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-CDKL1 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246186

ELISA (EIA) of anti-CDKL1 antibody

Detection limit for recombinant GST tagged CDKL1 is approximately 0.1 ng/ml as a capture antibody.
Mouse Anti-CDKL1 Monoclonal Antibody, ELISA (EIA) – Cat# MBS246186

Other Notes

Small volumes of anti-CDKL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CDKL1 purchase

MBS246186 is an antibody targeting CDKL1. Also known as Mouse Monoclonal [clone 2H6] (IgG2a,k) to Human CDKL1. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CDKL1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
cyclin-dependent kinase-like 1 isoform 1
NCBI Official Synonym Full Names
cyclin-dependent kinase-like 1 (CDC2-related kinase)
NCBI Official Symbol
CDKL1
NCBI Official Synonym Symbols
P42; KKIALRE
UniProt Protein Name
Cyclin-dependent kinase-like 1
UniProt Synonym Protein Names
Protein kinase p42 KKIALRE; Serine/threonine-protein kinase KKIALRE
UniProt Gene Name
CDKL1
UniProt Entry Name
CDKL1_HUMAN
NCBI Protein Information
cyclin-dependent kinase-like 1; CDC2-related kinase 1; protein kinase p42 KKIALRE; serine/threonine protein kinase KKIALRE; serine/threonine-protein kinase KKIALRE

NCBI Summary for CDKL1

This gene product is a member of a large family of CDC2-related serine/threonine protein kinases. It accumulates primarily in the nucleus. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2013]

UniProt Comments for CDKL1

CDKL1: a protein kinase of the CDKL family. Accumulates primarily in the nucleus.

Protein type: EC 2.7.11.22; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); Cell cycle regulation; Kinase, protein; CMGC group; CDKL family

Chromosomal Location of Human Ortholog: 14q21.3

Cellular Component: cytoplasm; nucleus

Molecular Function: cyclin-dependent protein kinase activity; ATP binding

Biological Process: regulation of cell cycle; heart development; protein amino acid phosphorylation
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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