TRPM7 Antibody – Mouse Monoclonal

The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2014]

ChaK1: is an unusual and ubiquitous bifunctional protein containing a transient receptor potential (TRP) ion channel fused to a protein kinase of the Atypical alpha group. Required for early embryonic development and for maintaining cardiac automaticity. The channel conducts Zn(2+), Mg(2+), and Ca(2+) as well as monovalent cations. The kinase can be cleaved from the channel domain. The cleaved kinase translocates to the nucleus where it binds chromatin-remodeling complexes including Polycomb, and phosphorylates specific histone residues. The kinase activity is essential for the channel function, and channel function is critical to maintain physiological intracellular magnesium levels. Plays a key role in oxidative stress-induced cell death. TRP voltage-independent calcium-permeable cation channels are divided into six subfamilies, two of which (TRPC and TRPM) have members that are widely expressed and activated by oxidative stress. Is activated by reactive oxygen/nitrogen species, resulting in cation conductance and anoxic neuronal cell death. This phenotype is rescued by suppression of ChaK1 expression. Related to ChaK2, another Atypical alpha kinase fused to a TRP ion channel protein.

Protein type: Kinase, protein; EC 2.7.11.1; Membrane protein, integral; Protein kinase, atypical; Channel, cation; Membrane protein, multi-pass; ATYPICAL group; Alpha family; ChaK subfamily

Chromosomal Location of Human Ortholog: 15q21

Cellular Component: ruffle; plasma membrane; integral to membrane

Molecular Function: protein serine/threonine kinase activity; myosin binding; calcium channel activity; metal ion binding; actin binding; ATP binding

Biological Process: protein amino acid autophosphorylation; actomyosin structure organization and biogenesis; calcium-dependent cell-matrix adhesion; transmembrane transport

Disease: Amyotrophic Lateral Sclerosis-parkinsonism/dementia Complex 1