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CBR Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246298

MBS246298 is an antibody targeting CBR. Also known as Mouse Monoclonal [clone AT4E12] (IgG2a,k) to Human CBR / CBR1. Reactive in Human, Mouse. Host: Mouse. More details

$650 / 0.05 mL +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
CBR / CBR1, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone AT4E12] (IgG2a,k) to Human CBR / CBR1
Product Gene Name
anti-CBR antibody
Product Synonym Gene Name
CBR1
Product Synonym Names
Anti-CBR / CBR1 Antibody (clone AT4E12) IHC-plus; CBR1; Carbonyl reductase 1; Carbonyl reductase (NADPH) 1; HCBR1; Prostaglandin 9-ketoreductase; SDR21C1; Carbonyl reductase [NADPH] 1; CBR; CRN; Prostaglandin-E(2) 9-reductase; Human CBR; CBR1
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
AT4E12
Host
Mouse
Species Reactivity
Human, Mouse
Form/Format
PBS, pH 7.4, 0.1% sodium azide. Sourced in Ascites.
Purity/Purification
Protein G Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human CBR1
Preparation and Storage
Can be stored at 4 degree C. For long term storage, aliquot and store at -20 degree C. Avoid repeated freezing and thawing cycles.
OMIM
114830
3D Structure
ModBase 3D Structure for P16152
Target Species
Human
Immunogen Description
Recombinant protein
Immunogen Type
Recombinant protein
Applications Tested/Suitable for anti-CBR antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-CBR antibody
ELISA, IHC-P (10 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-CBR antibody

Anti-CBR1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Mouse Anti-CBR Monoclonal Antibody – Cat# MBS246298

Western Blot (WB) of anti-CBR antibody

Cell lysates (40 ug) were resolved by SDS-PAGE, transferred to PVDF membrane and probed with anti-human CBR1 antibody (1:1000). Proteins were visualized using a goat anti-mouse secondary antibody conjugated to HRP and an ECL detection system.
Mouse Anti-CBR Monoclonal Antibody, Western Blot (WB) – Cat# MBS246298

Other Notes

Small volumes of anti-CBR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CBR. It may not necessarily be applicable to this product.

NCBI GI #
4502599
NCBI GeneID
873
NCBI Accession #
NP_001748.1
UniProt Primary Accession #
P16152
UniProt Secondary Accession #
Q3LHW8; B2RBZ7; B4DFK7
UniProt Related Accession #
P16152
GenBank Nucleotide #
NM_001757.3
NCBI Official Full Name
carbonyl reductase
NCBI Official Synonym Full Names
carbonyl reductase 1
NCBI Official Symbol
CBR1
NCBI Official Synonym Symbols
CBR; hCBR1; SDR21C1
UniProt Protein Name
Carbonyl reductase [NADPH] 1
UniProt Synonym Protein Names
15-hydroxyprostaglandin dehydrogenase [NADP(+)] (EC:1.1.1.197); NADPH-dependent carbonyl reductase 1; Prostaglandin 9-ketoreductase; Prostaglandin-E(2) 9-reductase (EC:1.1.1.189)
Protein Family
Carotene biosynthesis-related protein
UniProt Gene Name
CBR1
UniProt Synonym Gene Names
CBR; CRN
UniProt Entry Name
CBR1_HUMAN
NCBI Protein Information
carbonyl reductase [NADPH] 1; carbonyl reductase [NADPH] 1; carbonyl reductase (NADPH) 1; prostaglandin 9-ketoreductase; prostaglandin-E(2) 9-reductase; NADPH-dependent carbonyl reductase 1; 15-hydroxyprostaglandin dehydrogenase; short chain dehydrogenase/reductase family 21C, member 1

NCBI Summary for CBR

The protein encoded by this gene belongs to the short-chain dehydrogenases/reductases (SDR) family, which function as NADPH-dependent oxidoreductases having wide specificity for carbonyl compounds, such as quinones, prostaglandins, and various xenobiotics. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
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UniProt Comments for CBR

CBR1: NADPH-dependent reductase with broad substrate specificity. Catalyzes the reduction of a wide variety of carbonyl compounds including quinones, prostaglandins, menadione, plus various xenobiotics. Catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. Can convert prostaglandin E2 to prostaglandin F2-alpha. Can bind glutathione, which explains its higher affinity for glutathione-conjugated substrates. Catalyzes the reduction of S-nitrosoglutathione. Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Protein type: EC 1.1.1.189; EC 1.1.1.184; Oxidoreductase; Lipid Metabolism - arachidonic acid; EC 1.1.1.197

Chromosomal Location of Human Ortholog: 21q22.13

Cellular Component: cytosol; vesicle

Molecular Function: oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor; prostaglandin-E2 9-reductase activity; 15-hydroxyprostaglandin dehydrogenase (NADP+) activity; carbonyl reductase (NADPH) activity

Biological Process: epithelial cell differentiation; vitamin K metabolic process; cyclooxygenase pathway; arachidonic acid metabolic process; drug metabolic process
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Research Articles on CBR

1. we suggest that PEP-1-CBR1 protein may be a therapeutic agent for the treatment of ischemic injuries as well as oxidative-stress-induced cell damage and death.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CBR antibody

 Reference Product  PubMed Publications
 AKR1A1 antibody  >6 publications with CBR and AKR1A1
 PTGES2 antibody  >2 publications with CBR and PTGES2
 PTGES antibody  >2 publications with CBR and PTGES
 GCH1 antibody  >1 publications with CBR and GCH1
 SPR antibody  >1 publications with CBR and SPR
 AKR1B10 antibody  >1 publications with CBR and AKR1B10

Pathways associated with anti-CBR antibody

 Products by Pathway  Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Arachidonic Acid Metabolism Pathway antibodies  Arachidonic Acid Metabolism Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Chemical Carcinogenesis Pathway antibodies  Chemical Carcinogenesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram
 Metabolism Of Xenobiotics By Cytochrome P450 Pathway antibodies  Metabolism Of Xenobiotics By Cytochrome P450 Pathway Diagram

Diseases associated with anti-CBR antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >9 publications with CBR and Breast Neoplasms
 Liver Diseases Antibodies  >7 publications with CBR and Liver Diseases
 Liver Neoplasms Antibodies  >5 publications with CBR and Liver Neoplasms
 Fibrosis Antibodies  >4 publications with CBR and Fibrosis
 Necrosis Antibodies  >3 publications with CBR and Necrosis
 Heart Diseases Antibodies  >3 publications with CBR and Heart Diseases
 Carcinoma, Hepatocellular Antibodies  >3 publications with CBR and Carcinoma, Hepatocellular
 Weight Loss Antibodies  >2 publications with CBR and Weight Loss
 Inflammation Antibodies  >2 publications with CBR and Inflammation
 Liver Cirrhosis Antibodies  >2 publications with CBR and Liver Cirrhosis

Organs/Tissues associated with anti-CBR antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >21 publications with CBR and Liver
 Blood Antibodies  >11 publications with CBR and Blood
 Brain Antibodies  >11 publications with CBR and Brain
 Uterus Antibodies  >8 publications with CBR and Uterus
 Heart Antibodies  >6 publications with CBR and Heart
 Ovary Antibodies  >5 publications with CBR and Ovary
 Lung Antibodies  >5 publications with CBR and Lung
 Muscle Antibodies  >4 publications with CBR and Muscle
 Nerve Antibodies  >4 publications with CBR and Nerve
 Pancreas Antibodies  >3 publications with CBR and Pancreas
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