STT3A Antibody – Mouse Monoclonal

ITM1: Catalytic component of oligosaccharyltransferase (OST) oligosaccharyltransferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains. N- glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). SST3A seems to be involved in complex substrate specificity. STT3A is present in the majority of OST complexes and mediates cotranslational N-glycosylation of most sites on target proteins, while STT3B-containing complexes are required for efficient cotranslational glycosylation and mediate glycosylation of sites that have been skipped by STT3A. Belongs to the STT3 family.

Protein type: Transferase; Endoplasmic reticulum; EC 2.4.99.18; Membrane protein, multi-pass; Membrane protein, integral

Cellular Component: membrane; endoplasmic reticulum; integral to membrane

Molecular Function: transferase activity; transferase activity, transferring glycosyl groups; dolichyl-diphosphooligosaccharide-protein glycotransferase activity; oligosaccharyl transferase activity

Biological Process: co-translational protein modification; protein amino acid glycosylation; protein amino acid N-linked glycosylation via asparagine