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SFPQ Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246508

MBS246508 is an antibody targeting SFPQ. Also known as Mouse Monoclonal [clone 6D7] (IgG2a,k) to Human SFPQ. Reactive in Human. Host: Mouse. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SFPQ, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 6D7] (IgG2a,k) to Human SFPQ
Product Gene Name
anti-SFPQ antibody
Product Synonym Names
Anti-SFPQ Antibody (clone 6D7) IHC-plus; SFPQ; 100 kDa DNA-pairing protein; HPOMp100; PTB-associated splicing factor; PSF; POMP100; PTB-associated-splicing factor; Human SFPQ
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
6D7
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.2. Sourced in Ascites.
Purity/Purification
Protein A Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human SFPQ
Preparation and Storage
Store at -20 degree C or lower. Aliquot to avoid repeated freezing and thawing.
Molecular Weight
72,263 Da
OMIM
605199
3D Structure
ModBase 3D Structure for P23246
Target Species
Human
Immunogen Description
SFPQ (NP_005057, 269 a.a. ~ 362 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen
SFPQ antibody was raised against sFPQ (NP_005057, 269 a.a. ~ 362 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Applications Tested/Suitable for anti-SFPQ antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-SFPQ antibody
ELISA, IF (10 ug/ml), IHC-P (5 ug/ml), WB
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Western Blot using cell line lysates and the recombinant protein used as the immunogen.

Immunohistochemistry (IHC) of anti-SFPQ antibody

Anti-SFPQ antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-SFPQ Monoclonal Antibody – Cat# MBS246508

Immunofluorescence (IF) of anti-SFPQ antibody

Immunofluorescence of monoclonal antibody to SFPQ on HeLa cell. [antibody concentration 10 ug/ml]
Mouse Anti-SFPQ Monoclonal Antibody, Immunofluorescence (IF) – Cat# MBS246508

Western Blot (WB) of anti-SFPQ antibody

SFPQ monoclonal antibody clone 6D7 Western blot of SFPQ expression in HeLa NE.
Mouse Anti-SFPQ Monoclonal Antibody, Western Blot (WB) – Cat# MBS246508

ELISA (EIA) of anti-SFPQ antibody

Detection limit for recombinant GST tagged SFPQ is approximately 0.03 ng/ml as a capture antibody.
Mouse Anti-SFPQ Monoclonal Antibody, ELISA (EIA) – Cat# MBS246508

Other Notes

Small volumes of anti-SFPQ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SFPQ. It may not necessarily be applicable to this product.

NCBI GI #
4826998
NCBI GeneID
6421
NCBI Accession #
NP_005057.1
UniProt Primary Accession #
P23246
UniProt Secondary Accession #
P30808; Q5SZ71
UniProt Related Accession #
P23246
GenBank Nucleotide #
NM_005066.2
NCBI Official Full Name
splicing factor, proline- and glutamine-rich
NCBI Official Synonym Full Names
splicing factor proline/glutamine-rich
NCBI Official Symbol
SFPQ
NCBI Official Synonym Symbols
PSF; POMP100; PPP1R140
UniProt Protein Name
Splicing factor, proline- and glutamine-rich
UniProt Synonym Protein Names
100 kDa DNA-pairing protein; hPOMp100; DNA-binding p52/p100 complex, 100 kDa subunit; Polypyrimidine tract-binding protein-associated-splicing factor; PSF; PTB-associated-splicing factor
Protein Family
Splicing factor
UniProt Gene Name
SFPQ
UniProt Synonym Gene Names
PSF; hPOMp100; PSF; PTB-associated-splicing factor
UniProt Entry Name
SFPQ_HUMAN
NCBI Protein Information
splicing factor, proline- and glutamine-rich; hPOMp100; 100 kDa DNA-pairing protein; PTB-associated splicing factor; PTB-associated-splicing factor; DNA-binding p52/p100 complex, 100 kDa subunit; protein phosphatase 1, regulatory subunit 140; polypyrimidine tract binding protein associated; polypyrimidine tract-binding protein-associated splicing factor; polypyrimidine tract-binding protein-associated-splicing factor; splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated); splicing factor proline/glutamine rich (polypyrimidine tract-binding protein-associated)

UniProt Comments for SFPQ

PSF: a proline-and glutamine-rich splicing factor. Essential pre-mRNA splicing factor required early in spliceosome formation. Seems to also bind DNA. The active complex is a heterotetramer of two 52 kDa and two 100 kDa subunits. Reported to be a PKC-alpha-binding protein in the cell nucleus. Two alternatively spliced isoforms have been described.

Protein type: Nuclear receptor co-regulator; RNA-binding; RNA splicing

Chromosomal Location of Human Ortholog: 1p34.3

Cellular Component: nucleoplasm; nuclear matrix; cytoplasm; chromatin; nucleus; paraspeckles

Molecular Function: protein binding; histone deacetylase binding; nucleotide binding

Biological Process: alternative nuclear mRNA splicing, via spliceosome; transcription, DNA-dependent; RNA splicing; rhythmic process; negative regulation of circadian rhythm; negative regulation of transcription from RNA polymerase II promoter; mRNA processing; DNA repair; negative regulation of transcription, DNA-dependent; regulation of circadian rhythm; DNA recombination
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Research Articles on SFPQ

1. MALAT1 binds to SFPQ releasing PTBP2 from the SFPQ/PTBP2 complex, the increased SFPQ-detached PTBP2 promotes cell proliferation and migration in colorectal cancer.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SFPQ antibody

 Reference Product  PubMed Publications
 NONO antibody  >16 publications with SFPQ and NONO
 PSPC1 antibody  >7 publications with SFPQ and PSPC1
 HDAC1 antibody  >1 publications with SFPQ and HDAC1

Pathways associated with anti-SFPQ antibody

 Products by Pathway  Pathway Diagram
 MRNA Processing Pathway antibodies  MRNA Processing Pathway Diagram

Diseases associated with anti-SFPQ antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >4 publications with SFPQ and Nervous System Diseases
 Inflammation Antibodies  >3 publications with SFPQ and Inflammation
 Brain Diseases Antibodies  >2 publications with SFPQ and Brain Diseases
 Adenocarcinoma Antibodies  >2 publications with SFPQ and Adenocarcinoma
 Cell Transformation, Neoplastic Antibodies  >1 publications with SFPQ and Cell Transformation, Neoplastic
 Infertility, Female Antibodies  >1 publications with SFPQ and Infertility, Female
 Disease Models, Animal Antibodies  >1 publications with SFPQ and Disease Models, Animal
 Lung Neoplasms Antibodies  >1 publications with SFPQ and Lung Neoplasms
 Kidney Diseases Antibodies  >1 publications with SFPQ and Kidney Diseases
 Learning Disorders Antibodies  >1 publications with SFPQ and Learning Disorders

Organs/Tissues associated with anti-SFPQ antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with SFPQ and Brain
 Blood Antibodies  >5 publications with SFPQ and Blood
 Nerve Antibodies  >4 publications with SFPQ and Nerve
 Kidney Antibodies  >3 publications with SFPQ and Kidney
 Prostate Antibodies  >1 publications with SFPQ and Prostate
 Heart Antibodies  >1 publications with SFPQ and Heart
 Lymph Node Antibodies  >1 publications with SFPQ and Lymph Node
 Eye Antibodies  >1 publications with SFPQ and Eye
 Testis Antibodies  >1 publications with SFPQ and Testis
 Lymph Antibodies  >1 publications with SFPQ and Lymph
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