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CAMKK1 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246513

CAMKK1 belongs to the CAMKK subfamily of Serine/Threonine Kinases. CAMKK1 regulates the calcium/calmodulin-dependent protein kinase cascade by phosphorylating CAMKI, CAMKIV, and PKB. More details

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Product Overview

Product Name
CAMKK1 / CaMKK, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 1F6] (IgG1,k) to Human CAMKK1 / CaMKK
Product Gene Name
anti-CAMKK1 antibody
Product Synonym Gene Name
CaMKK
Product Synonym Names
Anti-CAMKK1 / CaMKK Antibody (clone 1F6) IHC-plus; CAMKK1; CaM-kinase IV kinase; CaM-kinase kinase 1; CaM-kinase kinase alpha; CAMKK alpha protein; CAMKKA; CaM-KK 1; CaMKK; CaM-KK alpha; CaMKK 1; CaMKK alpha; CAMKKalpha; Human CAMKK1; CaMKK
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
1F6
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.2. Sourced in Ascites.
Purity/Purification
Protein A Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human CaMKK
Preparation and Storage
Store at -20 degree C or lower. Aliquot to avoid repeated freezing and thawing.
Molecular Weight
57,523 Da
OMIM
611411
3D Structure
ModBase 3D Structure for Q8N5S9
Target Species
Human
Immunogen Description
CAMKK1 (AAH31647, 1 a.a. ~ 521 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen
CAMKK1 / CaMKK antibody was raised against cAMKK1 (AAH31647, 1 a.a. ~ 521 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Product Categories/Family for anti-CAMKK1 antibody

Family: Protein Kinase; Subfamily: CAMKK
Applications Tested/Suitable for anti-CAMKK1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-CAMKK1 antibody
ELISA, IHC-P (5 ug/ml), WB (1:500 - 1:1000)
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. RNAi Knockdown: Antibody validated. Sandwich ELISA: Recombinant protein. Western Blot: Cell lysate, Transfected lysate, Recombinant protein.

Immunohistochemistry (IHC) of anti-CAMKK1 antibody

Anti-CAMKK1 / CaMKK antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-CAMKK1 Monoclonal Antibody – Cat# MBS246513

Western Blot (WB) of anti-CAMKK1 antibody

Western blot of CAMKK1 expression in transfected 293T cell line by CAMKK1 monoclonal antibody, clone 1F6.
Mouse Anti-CAMKK1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS246513

Western Blot (WB) of anti-CAMKK1 antibody

Western blot of CAMKK1 expression in Jurkat cells by CAMKK1 monoclonal antibody, clone 1F6.
Mouse Anti-CAMKK1 Monoclonal Antibody, Western Blot (WB) – Cat# MBS246513

RNA interference of anti-CAMKK1 antibody

Western blot of CAMKK1 over-expressed 293 cell line, cotransfected with CAMKK1 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with CAMKK1 monoclonal antibody clone 1F6. GAPDH (36.1 kD) used as control.
Mouse Anti-CAMKK1 Monoclonal Antibody, RNA interference – Cat# MBS246513

ELISA (EIA) of anti-CAMKK1 antibody

Detection limit for recombinant GST tagged CAMKK1 is approximately 1 ng/ml as a capture antibody.
Mouse Anti-CAMKK1 Monoclonal Antibody, ELISA (EIA) – Cat# MBS246513

Other Notes

Small volumes of anti-CAMKK1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CAMKK1 purchase

MBS246513 is an antibody targeting CAMKK1. Also known as Mouse Monoclonal [clone 1F6] (IgG1,k) to Human CAMKK1 / CaMKK. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for CAMKK1. It may not necessarily be applicable to this product.

NCBI GI #
14150045
NCBI GeneID
84254
NCBI Accession #
NP_115670.1
UniProt Primary Accession #
Q8N5S9
UniProt Secondary Accession #
Q9BQH3
UniProt Related Accession #
Q8N5S9
GenBank Nucleotide #
NM_032294.2
NCBI Official Full Name
calcium/calmodulin-dependent protein kinase kinase 1 isoform a
NCBI Official Synonym Full Names
calcium/calmodulin-dependent protein kinase kinase 1, alpha
NCBI Official Symbol
CAMKK1
NCBI Official Synonym Symbols
CAMKKA
UniProt Protein Name
Calcium/calmodulin-dependent protein kinase kinase 1
UniProt Synonym Protein Names
CaM-kinase IV kinase; Calcium/calmodulin-dependent protein kinase kinase alpha; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha
Protein Family
Calcium/calmodulin-dependent protein kinase
UniProt Gene Name
CAMKK1
UniProt Synonym Gene Names
CAMKKA; CaM-KK 1; CaM-kinase kinase 1; CaMKK 1; CaM-KK alpha; CaM-kinase kinase alpha; CaMKK alpha
UniProt Entry Name
KKCC1_HUMAN
NCBI Protein Information
calcium/calmodulin-dependent protein kinase kinase 1; caMKK 1; caM-KK 1; caM-KK alpha; CAMKK alpha protein; caM-kinase kinase 1; caM-kinase IV kinase; caM-kinase kinase alpha; calcium/calmodulin-dependent protein kinase kinase alpha

NCBI Summary for CAMKK1

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
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UniProt Comments for CAMKK1

CAMKK1: a calcium/calmodulin-dependent S/T protein kinase of the CAMKK family. Phosphorylates CAMK1, CAMK1D, CAMK1G and CAMK4. Involved in regulating cell apoptosis. Promotes cell survival by phosphorylating AKT1/PKB that inhibits pro-apoptotic BAD/Bcl2-antagonist of cell death. 2 isoforms of the human protein are produced by alternative splicing. The autoinhibitory domain overlaps with the calmodulin binding region and may be involved in intrasteric autoinhibition. Binding of calmodulin may releave intrasteric autoinhibition. May be regulated through phosphorylation by CAMK1 and CAMK4. Appears to be autophosphorylated in a Ca2+/calmodulin-dependent manner. Phosphorylation of Ser-458 is blocked upon binding to Ca2+/calmodulin.

Protein type: Protein kinase, Ser/Thr (non-receptor); Protein kinase, Other; Kinase, protein; EC 2.7.11.17; Other group; CAMKK family; Meta subfamily

Chromosomal Location of Human Ortholog: 17p13.2

Cellular Component: nucleus; cytosol

Molecular Function: calmodulin binding; protein binding; calmodulin-dependent protein kinase activity; ATP binding

Biological Process: synaptic transmission; protein amino acid phosphorylation
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Research Articles on CAMKK1

1. CAMKK1 might contribute to the risk of lung cancer in Chinese populations.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-CAMKK1 antibody

 Products by Pathway  Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 AMPK Signaling Pathway antibodies  AMPK Signaling Pathway Diagram
 Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway antibodies  Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Adipocytokine Signaling Pathway antibodies  Adipocytokine Signaling Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 Alcoholism Pathway antibodies  Alcoholism Pathway Diagram
 CREB Phosphorylation Through The Activation Of CaMKK Pathway antibodies  CREB Phosphorylation Through The Activation Of CaMKK Pathway Diagram
 Neuronal System Pathway antibodies  Neuronal System Pathway Diagram

Diseases associated with anti-CAMKK1 antibody

 Disease Name  Pubmed Publications
 Memory Disorders Antibodies  >1 publications with CAMKK1 and Memory Disorders
 Inflammation Antibodies  >1 publications with CAMKK1 and Inflammation
 Neurobehavioral Manifestations Antibodies  >1 publications with CAMKK1 and Neurobehavioral Manifestations
 Nervous System Diseases Antibodies  >1 publications with CAMKK1 and Nervous System Diseases

Organs/Tissues associated with anti-CAMKK1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >8 publications with CAMKK1 and Brain
 Lung Antibodies  >4 publications with CAMKK1 and Lung
 Muscle Antibodies  >3 publications with CAMKK1 and Muscle
 Nerve Antibodies  >2 publications with CAMKK1 and Nerve
 Embryonic Tissue Antibodies  >1 publications with CAMKK1 and Embryonic Tissue
 Pancreas Antibodies  >1 publications with CAMKK1 and Pancreas
 Heart Antibodies  >1 publications with CAMKK1 and Heart
 Ovary Antibodies  >1 publications with CAMKK1 and Ovary
 Bone Antibodies  >1 publications with CAMKK1 and Bone
 Kidney Antibodies  >1 publications with CAMKK1 and Kidney
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