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POU2F2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246573

MBS246573 is an antibody targeting POU2F2. Also known as Mouse Monoclonal [clone 3E3-6F9] (IgG1,k) to Human POU2F2 / OCT2. Reactive in Human. Host: Mouse. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
POU2F2 / OCT2, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 3E3-6F9] (IgG1,k) to Human POU2F2 / OCT2
Product Gene Name
anti-POU2F2 antibody
Product Synonym Gene Name
OCT2
Product Synonym Names
Anti-POU2F2 / OCT2 Antibody (clone 3E3-6F9) IHC-plus; POU2F2; Homeobox protein; Oct-2; OCT2; Octamer-binding protein 2; OTF-2; OTF2; POU class 2 homeobox 2; Human POU2F2; OCT2
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
3E3-6F9
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.4.
Purity/Purification
Protein A Purified
Concentration
0.42 mg/ml (lot specific)
Specificity
Human POU2F2
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
62,172 Da
OMIM
164176
3D Structure
ModBase 3D Structure for P09086
Target Species
Human
Immunogen Description
POU2F2 (AAH06101, 1 a.a. ~ 401 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen
POU2F2 / OCT2 antibody was raised against pOU2F2 (AAH06101, 1 a.a. ~ 401 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Applications Tested/Suitable for anti-POU2F2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-POU2F2 antibody
ELISA, IHC-P (5 ug/ml), WB
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Western blot using cell line lysates and the recombinant protein used as the immunogen.

Immunohistochemistry (IHC) of anti-POU2F2 antibody

Anti-POU2F2 / Oct-2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-POU2F2 Monoclonal Antibody – Cat# MBS246573

Western Blot (WB) of anti-POU2F2 antibody

POU2F2 monoclonal antibody clone 3E3-6F9 Western blot of POU2F2 expression in HL-60.
Mouse Anti-POU2F2 Monoclonal Antibody, Western Blot (WB) – Cat# MBS246573

Other Notes

Small volumes of anti-POU2F2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for POU2F2. It may not necessarily be applicable to this product.

NCBI GI #
4505959
NCBI GeneID
5452
NCBI Accession #
NP_002689.1
UniProt Primary Accession #
P09086
UniProt Secondary Accession #
Q16648; Q7M4M8; Q9BRS4
UniProt Related Accession #
P09086
GenBank Nucleotide #
NM_002698.4
NCBI Official Full Name
POU domain, class 2, transcription factor 2 isoform 2
NCBI Official Synonym Full Names
POU class 2 homeobox 2
NCBI Official Symbol
POU2F2
NCBI Official Synonym Symbols
OCT2; OTF2; Oct-2
UniProt Protein Name
POU domain, class 2, transcription factor 2
UniProt Synonym Protein Names
Lymphoid-restricted immunoglobulin octamer-binding protein NF-A2; Octamer-binding protein 2; Oct-2; Octamer-binding transcription factor 2; OTF-2
Protein Family
POU domain, class 2, transcription factor
UniProt Gene Name
POU2F2
UniProt Synonym Gene Names
OCT2; OTF2; Oct-2; OTF-2
UniProt Entry Name
PO2F2_HUMAN
NCBI Protein Information
POU domain, class 2, transcription factor 2; OTF-2; homeobox protein; octamer-binding protein 2; octamer-binding transcription factor 2; lymphoid-restricted immunoglobulin octamer-binding protein NF-A2

NCBI Summary for POU2F2

The protein encoded by this gene is a homeobox-containing transcription factor of the POU domain family. The encoded protein binds the octamer sequence 5'-ATTTGCAT-3', a common transcription factor binding site in immunoglobulin gene promoters. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
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UniProt Comments for POU2F2

Oct2: Transcription factor that specifically binds to the octamer motif (5'-ATTTGCAT-3'). Regulates transcription in a number of tissues in addition to activating immunoglobulin gene expression. Modulates transcription transactivation by NR3C1, AR and PGR. Isoform 5 activates the U2 small nuclear RNA (snRNA) promoter. Belongs to the POU transcription factor family. Class- 2 subfamily. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: DNA-binding

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytoplasm; nucleus

Molecular Function: protein domain specific binding; sequence-specific DNA binding; transcription factor activity

Biological Process: immunoglobulin secretion during immune response; transcription from RNA polymerase II promoter; mature B cell differentiation; positive regulation of transcription, DNA-dependent; cell maturation; humoral immune response
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Research Articles on POU2F2

1. a differential control exerted by both Oct-1 and Oct-2 in the transcriptional regulation of the HMGA1 gene

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-POU2F2 antibody

 Reference Product  PubMed Publications
 POU2AF1 antibody  >38 publications with POU2F2 and POU2AF1
 TBP antibody  >4 publications with POU2F2 and TBP
 HMGA1 antibody  >3 publications with POU2F2 and HMGA1
 RELA antibody  >1 publications with POU2F2 and RELA

Pathways associated with anti-POU2F2 antibody

 Products by Pathway  Pathway Diagram
 BCR Signaling Pathway antibodies  BCR Signaling Pathway Diagram
 SIDS Susceptibility Pathways antibodies  SIDS Susceptibility Pathways Diagram

Diseases associated with anti-POU2F2 antibody

 Disease Name  Pubmed Publications
 Immune System Diseases Antibodies  >33 publications with POU2F2 and Immune System Diseases
 Neoplasms, Experimental Antibodies  >4 publications with POU2F2 and Neoplasms, Experimental
 Nervous System Diseases Antibodies  >3 publications with POU2F2 and Nervous System Diseases
 Inflammation Antibodies  >3 publications with POU2F2 and Inflammation
 Disease Models, Animal Antibodies  >2 publications with POU2F2 and Disease Models, Animal
 Necrosis Antibodies  >2 publications with POU2F2 and Necrosis
 Liver Neoplasms Antibodies  >1 publications with POU2F2 and Liver Neoplasms
 Breast Neoplasms Antibodies  >1 publications with POU2F2 and Breast Neoplasms
 Fibrosis Antibodies  >1 publications with POU2F2 and Fibrosis
 Hyperplasia Antibodies  >1 publications with POU2F2 and Hyperplasia

Organs/Tissues associated with anti-POU2F2 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >119 publications with POU2F2 and Blood
 Brain Antibodies  >23 publications with POU2F2 and Brain
 Lymph Node Antibodies  >8 publications with POU2F2 and Lymph Node
 Lymph Antibodies  >7 publications with POU2F2 and Lymph
 Bone Antibodies  >6 publications with POU2F2 and Bone
 Embryonic Tissue Antibodies  >3 publications with POU2F2 and Embryonic Tissue
 Liver Antibodies  >3 publications with POU2F2 and Liver
 Kidney Antibodies  >2 publications with POU2F2 and Kidney
 Tonsil Antibodies  >2 publications with POU2F2 and Tonsil
 Testis Antibodies  >2 publications with POU2F2 and Testis
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