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SLC13A5 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246619

MBS246619 is an antibody targeting SLC13A5. Also known as Mouse Monoclonal [clone 2G4] (IgG1,k) to Human SLC13A5. Reactive in Human. Host: Mouse. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
SLC13A5, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 2G4] (IgG1,k) to Human SLC13A5
Product Gene Name
anti-SLC13A5 antibody
Product Synonym Names
Anti-SLC13A5 Antibody (clone 2G4) IHC-plus; SLC13A5; Na(+)/citrate cotransporter; NACT; Human SLC13A5
Clonality
Monoclonal
Isotype
IgG1,k
Clone Number
2G4
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.2. Sourced in Ascites.
Purity/Purification
Protein A Purified
Concentration
0.2 mg/ml (lot specific)
Specificity
Human SLC13A5
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
58,092 Da
OMIM
608305
3D Structure
ModBase 3D Structure for Q86YT5
Target Species
Human
Immunogen Description
SLC13A5 (NP_808218, 152 a.a. ~ 207 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen
SLC13A5 antibody was raised against sLC13A5 (NP_808218, 152 a.a. ~ 207 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Applications Tested/Suitable for anti-SLC13A5 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-SLC13A5 antibody
ELISA, IHC-P (5 ug/ml), WB (1:500 - 1:1000)
Usage: Immunohistochemistry: Formalin-fixed paraffin-embedded sections. Sandwich ELISA: Recombinant protein. Western Blot using cell line lysates and the recombinant protein used as the immunogen.

Immunohistochemistry (IHC) of anti-SLC13A5 antibody

Anti-SLC13A5 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-SLC13A5 Monoclonal Antibody – Cat# MBS246619

Western Blot (WB) of anti-SLC13A5 antibody

SLC13A5 monoclonal antibody, clone 2G4. Western blot of SLC13A5 expression in HepG2.
Mouse Anti-SLC13A5 Monoclonal Antibody, Western Blot (WB) – Cat# MBS246619

ELISA (EIA) of anti-SLC13A5 antibody

Detection limit for recombinant GST tagged SLC13A5 is 0.03 ng/ml as a capture antibody.
Mouse Anti-SLC13A5 Monoclonal Antibody, ELISA (EIA) – Cat# MBS246619

Other Notes

Small volumes of anti-SLC13A5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SLC13A5. It may not necessarily be applicable to this product.

NCBI GI #
219802232
NCBI GeneID
284111
NCBI Accession #
NP_001137310.1
UniProt Primary Accession #
Q86YT5
UniProt Secondary Accession #
Q6ZMG1; B3KXR0; B7Z4P2; B7ZLB4; F8W7N2
UniProt Related Accession #
Q86YT5
GenBank Nucleotide #
NM_001143838.2
NCBI Official Full Name
solute carrier family 13 member 5 isoform b
NCBI Official Synonym Full Names
solute carrier family 13 (sodium-dependent citrate transporter), member 5
NCBI Official Symbol
SLC13A5
NCBI Official Synonym Symbols
NACT; mIndy; EIEE25
UniProt Protein Name
Solute carrier family 13 member 5
UniProt Synonym Protein Names
Na(+)/citrate cotransporter; NaCT; Sodium-coupled citrate transporter; Sodium-dependent citrate transporter
Protein Family
Solute carrier family
UniProt Gene Name
SLC13A5
UniProt Synonym Gene Names
NACT; NaCT
UniProt Entry Name
S13A5_HUMAN
NCBI Protein Information
solute carrier family 13 member 5; Na(+)/citrate cotransporter; Na+-coupled citrate transporter protein; sodium-dependent dicarboxylate transporter

NCBI Summary for SLC13A5

This gene encodes a protein belonging to the solute carrier family 13 group of proteins. This family member is a sodium-dependent citrate cotransporter that may regulate metabolic processes. Mutations in this gene cause early infantile epileptic encephalopathy 25. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2014]
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UniProt Comments for SLC13A5

SLC13A5: High-affinity sodium/citrate cotransporter that mediates citrate entry into cells. The transport process is electrogenic; it is the trivalent form of citrate rather than the divalent form that is recognized as a substrate. May facilitate the utilization of circulating citrate for the generation of metabolic energy and for the synthesis of fatty acids and cholesterol. Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Transporter; Membrane protein, multi-pass; Transporter, SLC family

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: basolateral plasma membrane; integral to membrane; plasma membrane

Molecular Function: citrate transmembrane transporter activity; succinate transmembrane transporter activity; sodium:dicarboxylate symporter activity

Biological Process: citrate transport; sodium ion transport; transmembrane transport

Disease: Epileptic Encephalopathy, Early Infantile, 25
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Research Articles on SLC13A5

1. Screening of 68 additional unrelated individuals with early-onset epileptic encephalopathy for SLC13A5 mutations led to identification of one additional subject with heterozygous mutations of SLC13A5 and a similar clinical presentation as index subjects

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-SLC13A5 antibody

 Products by Pathway  Pathway Diagram
 SLC-mediated Transmembrane Transport Pathway antibodies  SLC-mediated Transmembrane Transport Pathway Diagram
 Sodium-coupled Sulphate, Di- And Tri-carboxylate Transporters Pathway antibodies  Sodium-coupled Sulphate, Di- And Tri-carboxylate Transporters Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram
 Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway antibodies  Transport Of Glucose And Other Sugars, Bile Salts And Organic Acids, Metal Ions And Amine Compounds Pathway Diagram

Diseases associated with anti-SLC13A5 antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >3 publications with SLC13A5 and Fatty Liver
 Carcinoma Antibodies  >3 publications with SLC13A5 and Carcinoma
 Liver Diseases Antibodies  >2 publications with SLC13A5 and Liver Diseases
 Kidney Diseases Antibodies  >2 publications with SLC13A5 and Kidney Diseases
 Liver Neoplasms Antibodies  >2 publications with SLC13A5 and Liver Neoplasms
 Seizures Antibodies  >1 publications with SLC13A5 and Seizures
 Kidney Neoplasms Antibodies  >1 publications with SLC13A5 and Kidney Neoplasms
 Fibrosis Antibodies  >1 publications with SLC13A5 and Fibrosis
 Colonic Neoplasms Antibodies  >1 publications with SLC13A5 and Colonic Neoplasms
 Disease Models, Animal Antibodies  >1 publications with SLC13A5 and Disease Models, Animal

Organs/Tissues associated with anti-SLC13A5 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >10 publications with SLC13A5 and Liver
 Brain Antibodies  >5 publications with SLC13A5 and Brain
 Testis Antibodies  >2 publications with SLC13A5 and Testis
 Eye Antibodies  >1 publications with SLC13A5 and Eye
 Mouth Antibodies  >1 publications with SLC13A5 and Mouth
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