• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

IPP2 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246645

MBS246645 is an antibody targeting IPP2. Also known as Mouse Monoclonal [clone 2E9] (IgG2a,k) to Human IPP2 / PPP1R2. Reactive in Human. Host: Mouse. More details

DISCONTINUED
Click here to view our similar product(s) OR click here to contact our technical support team for suitable replacement.
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Product Name
IPP2 / PPP1R2, Monoclonal Antibody
Full Product Name
Mouse Monoclonal [clone 2E9] (IgG2a,k) to Human IPP2 / PPP1R2
Product Gene Name
anti-IPP2 antibody
Product Synonym Gene Name
PPP1R2
Product Synonym Names
Anti-IPP2 / PPP1R2 Antibody (clone 2E9) IHC-plus; PPP1R2; IPP-2; Phosphoprotein phosphatase; IPP2; Phosphatase inhibitor 2; Human IPP2; PPP1R2
Clonality
Monoclonal
Isotype
IgG2a,k
Clone Number
2E9
Host
Mouse
Species Reactivity
Human
Form/Format
PBS, pH 7.2. Sourced in Ascites.
Purity/Purification
Protein A Purified
Concentration
0.47 mg/ml (lot specific)
Preparation and Storage
Store at -20 degree C. Aliquot to avoid freeze/thaw cycles.
Molecular Weight
23,015 Da
OMIM
601792
3D Structure
ModBase 3D Structure for P41236
Target Species
Human
Immunogen Description
PPP1R2 (NP_006232, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Immunogen Type
Recombinant protein
Immunogen
IPP2 / PPP1R2 antibody was raised against pPP1R2 (NP_006232, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Applications Tested/Suitable for anti-IPP2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-IPP2 antibody
ELISA, IHC-P (5 ug/ml), WB
Usage: Western blot performed with the recombinant protein used as the immunogen.

Immunohistochemistry (IHC) of anti-IPP2 antibody

Anti-PPP1R2 antibody IHC of human testis. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-IPP2 Monoclonal Antibody – Cat# MBS246645

Immunohistochemistry (IHC) of anti-IPP2 antibody

Anti-PPP1R2 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Mouse Anti-IPP2 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246645

Other Notes

Small volumes of anti-IPP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for IPP2. It may not necessarily be applicable to this product.

NCBI GI #
5453946
NCBI GeneID
5504
NCBI Accession #
NP_006232.1
UniProt Primary Accession #
P41236
UniProt Related Accession #
P41236
GenBank Nucleotide #
NM_006241.7
NCBI Official Full Name
protein phosphatase inhibitor 2 isoform 2
NCBI Official Synonym Full Names
protein phosphatase 1, regulatory (inhibitor) subunit 2
NCBI Official Symbol
PPP1R2
NCBI Official Synonym Symbols
IPP2; IPP-2
UniProt Protein Name
Protein phosphatase inhibitor 2
UniProt Gene Name
PPP1R2
UniProt Synonym Gene Names
IPP2; IPP-2
UniProt Entry Name
IPP2_HUMAN
NCBI Protein Information
protein phosphatase inhibitor 2; phosphoprotein phosphatase

UniProt Comments for IPP2

PPP1R2: a member of the protein phosphatase inhibitor 1 family. A dopamine- and cyclic AMP-regulated neuronal phosphoprotein. Both dopaminergic and glutamatergic (NMDA) receptor stimulation regulate the extent of DARPP32 phosphorylation, but in opposite directions. Dopamine D1 receptor stimulation enhances cAMP formation, resulting in the phosphorylation of DARPP32; phosphorylated DARPP32 is a potent protein phosphatase-1 inhibitor. NMDA receptor stimulation elevates intracellular calcium, which leads to activation of calcineurin and dephosphorylation of phospho-DARPP32, thereby reducing the phosphatase-1 inhibitory activity of DARPP32. Two alternatively-spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Inhibitor; Protein phosphatase, regulatory subunit

Chromosomal Location of Human Ortholog: 3q29

Molecular Function: protein binding; type 1 serine/threonine specific protein phosphatase inhibitor activity

Biological Process: glycogen metabolic process; generation of precursor metabolites and energy; negative regulation of catalytic activity; regulation of signal transduction; regulation of phosphoprotein phosphatase activity
Show more

Research Articles on IPP2

1. The results show that contrary to initial observations PPP1R2-related pseudogenes are not simple bystanders of the evolutionary process but may rather be at the origin of genes with novel functions.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-IPP2 antibody

 Reference Product  PubMed Publications
 PPP1CB antibody  >2 publications with IPP2 and PPP1CB
 PPP1CC antibody  >2 publications with IPP2 and PPP1CC
 PPP1R1A antibody  >1 publications with IPP2 and PPP1R1A
 PPP1CA antibody  >1 publications with IPP2 and PPP1CA

Diseases associated with anti-IPP2 antibody

 Disease Name  Pubmed Publications
 Seizures Antibodies  >1 publications with IPP2 and Seizures
 Kidney Diseases Antibodies  >1 publications with IPP2 and Kidney Diseases

Organs/Tissues associated with anti-IPP2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with IPP2 and Brain
 Nerve Antibodies  >1 publications with IPP2 and Nerve
 Kidney Antibodies  >1 publications with IPP2 and Kidney
 Lung Antibodies  >1 publications with IPP2 and Lung
 Testis Antibodies  >1 publications with IPP2 and Testis
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

MBS000000
Contact Us

Please fill out the form below and our representative will get back to you shortly.

MBS000000