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MRGX1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246703

MRGX1 belongs to the Opioid Receptor subfamily because this receptor is activated by products of proenkephalin A, an opioid peptide precursor. More details

$630 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MRGX1 / MRGPRX1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human MRGX1 / MRGPRX1
Product Gene Name
anti-MRGX1 antibody
Product Synonym Gene Name
MRGPRX1
Product Synonym Names
Anti-MRGX1 / MRGPRX1 Antibody (N-Terminus) IHC-plus; MRGPRX1; MRGX1; SNSR4; SNSR3; MAS-related GPR; member X1; Human MRGX1; MRGPRX1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Monkey
Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human MRGPRX1 / MRGX1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except MRGPRX3 (71%).
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
36,250 Da
OMIM
607227
3D Structure
ModBase 3D Structure for Q96LB2
Target Species
Human
Immunogen Description
Synthetic 14 amino acid peptide from N-terminal extracellular domain of human MRGPRX1 / MRGX1. Percent identity with other species by BLAST analysis: Human, Monkey (100%); Gibbon (93%).
Immunogen Type
Synthetic peptide
Immunogen
MRGX1 / MRGPRX1 antibody was raised against synthetic 14 amino acid peptide from N-terminal extracellular domain of human MRGPRX1 / MRGX1. Percent identity with other species by BLAST analysis: Human, Monkey (100%); Gibbon (93%).
Antigen Modification
N-Terminus

Product Categories/Family for anti-MRGX1 antibody

Family: GPCR; Subfamily: Opioid
Applications Tested/Suitable for anti-MRGX1 antibody
Immunohistochemistry (IHC - Paraffin), Immunocytochemistry (ICC)
Application Notes for anti-MRGX1 antibody
ICC, IHC-P (12 ug/ml)

Immunohistochemistry (IHC) of anti-MRGX1 antibody

Anti-MRGX1 / MRGPRX1 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-MRGX1 Polyclonal Antibody – Cat# MBS246703

Immunohistochemistry (IHC) of anti-MRGX1 antibody

Anti-MRGX1 / MRGPRX1 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-MRGX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246703

Immunohistochemistry (IHC) of anti-MRGX1 antibody

Anti-MRGPRX1 / MRGX1 antibody IHC of human ganglion cells and Schwann cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-MRGX1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246703

Other Notes

Small volumes of anti-MRGX1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MRGX1 purchase

MBS246703 is an antibody targeting MRGX1. Also known as Rabbit Polyclonal to Human MRGX1 / MRGPRX1. Reactive in Human, Monkey
Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MRGX1. It may not necessarily be applicable to this product.

NCBI GI #
125660451
NCBI GeneID
259249
NCBI Accession #
NP_671732.3
UniProt Primary Accession #
Q96LB2
UniProt Secondary Accession #
Q4V9L2; Q8TDD8; Q8TDD9
UniProt Related Accession #
Q96LB2
GenBank Nucleotide #
NM_147199.3
NCBI Official Full Name
mas-related G-protein coupled receptor member X1
NCBI Official Synonym Full Names
MAS-related GPR, member X1
NCBI Official Symbol
MRGPRX1
NCBI Official Synonym Symbols
GPCR; MGRG2; MRGX1; SNSR4
UniProt Protein Name
Mas-related G-protein coupled receptor member X1
UniProt Synonym Protein Names
Sensory neuron-specific G-protein coupled receptor 3/4
UniProt Gene Name
MRGPRX1
UniProt Synonym Gene Names
MRGX1; SNSR3; SNSR4
UniProt Entry Name
MRGX1_HUMAN
NCBI Protein Information
mas-related G-protein coupled receptor member X1; G protein-coupled receptor MRGX1; G protein-coupled receptor SNSR3; Mas-related G protein-coupled receptor G2; sensory neuron-specific G-protein coupled receptor 3/4

UniProt Comments for MRGX1

MRGPRX1: Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in an histamine-independent manner. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11p15.1|11

Cellular Component: integral to membrane; plasma membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; acute-phase response
Show more

Research Articles on MRGX1

1. analysis of the functional interactions between MRGPR-X1 and TRPV1

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.
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