Rabbit Anti-CCR8 Polyclonal Antibody – Cat# MBS246706

Anti-CCR8 antibody IHC of human tonsil, germinal center. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

CCR8 Antibody – Rabbit Polyclonal

Name: CCR8 Antibody; Polyclonal; Rabbit; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS246706
Price: 630 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246706

CCR8, a Chemokine Receptor, binds the CC-chemokine I-309, which is secreted by umbilical vein endothelial cells. CCR8 also binds viral monocyte inflammatory protein-I (vMIP-I), which is induced by Kaposi sarcoma-related human herpesvirus-8. CCR8 induces… More details

$630 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

CCR8, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human CCR8

Product Gene Name

anti-CCR8 antibody

Product Synonym Names

Anti-CCR8 Antibody (N-Terminus) IHC-plus; CCR8; C-C chemokine receptor type 8; CC chemokine receptor CHEMR1; CC-CKR-8; Chemokine (C-C) receptor 8; CDw198 antigen; CKRL1; CMKBR8; Chemokine receptor-like 1; CMKBRL2; CKR-L1; GPRCY6; TER1; C-C CKR-8; CC chemokine receptor 8; Human CCR8

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Gorilla, Human

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human CCR8. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

31,622 Da

OMIM

601834

3D Structure

ModBase 3D Structure for P51685

Target Species

Human

Immunogen Description

Synthetic 17 amino acid peptide from N-terminal extracellular domain of human CCR8. Percent identity with other species by BLAST analysis: Human, Gorilla (100%).

Immunogen Type

Synthetic peptide

Immunogen

CCR8 antibody was raised against synthetic 17 amino acid peptide from N-terminal extracellular domain of human CCR8. Percent identity with other species by BLAST analysis: Human, Gorilla (100%).

Antigen Modification

N-Terminus

Product Categories/Family for anti-CCR8 antibody

Family: GPCR; Subfamily: Chemokine

Applications Tested/Suitable for anti-CCR8 antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-CCR8 antibody

IHC-P (3 - 8 ug/ml)

Other Notes

Small volumes of anti-CCR8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CCR8 purchase

MBS246706 is an antibody targeting CCR8. Also known as Rabbit Polyclonal to Human CCR8. Reactive in Gorilla, Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CCR8. It may not necessarily be applicable to this product.

NCBI GI #

4885121

NCBI GeneID

1237

NCBI Accession #

NP_005192.1

UniProt Primary Accession #

P51685

UniProt Secondary Accession #

Q3KNQ8; Q3KNR3; Q9BYX5; B2RC64

UniProt Related Accession #

P51685

GenBank Nucleotide #

NM_005201.3

NCBI Official Full Name

C-C chemokine receptor type 8

NCBI Official Synonym Full Names

chemokine (C-C motif) receptor 8

NCBI Official Symbol

CCR8

NCBI Official Synonym Symbols

CY6; TER1; CCR-8; CKRL1; CDw198; CMKBR8; GPRCY6; CMKBRL2; CC-CKR-8

UniProt Protein Name

C-C chemokine receptor type 8

UniProt Synonym Protein Names

CC chemokine receptor CHEMR1; CMKBRL2; Chemokine receptor-like 1; CKR-L1; GPR-CY6; GPRCY6; TER1; CD_antigen: CDw198

Protein Family

C-C chemokine receptor

UniProt Gene Name

CCR8

UniProt Synonym Gene Names

CKRL1; CMKBR8; CMKBRL2; C-C CKR-8; CC-CKR-8; CCR-8; CKR-L1; GPRCY6

UniProt Entry Name

CCR8_HUMAN

NCBI Protein Information

C-C chemokine receptor type 8; CC chemokine receptor 8; chemokine receptor-like 1; chemokine (C-C) receptor 8; CC chemokine receptor CHEMR1; CC-chemokine receptor chemr1; chemokine (C-C) receptor-like 2

NCBI Summary for CCR8

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]

UniProt Comments for CCR8

CCR8: Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR; Motility/polarity/chemotaxis; GPCR, family 1

Chromosomal Location of Human Ortholog: 3p22

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: C-C chemokine receptor activity; chemokine receptor activity; coreceptor activity

Biological Process: G-protein coupled receptor protein signaling pathway; elevation of cytosolic calcium ion concentration; immune response; cell adhesion; chemotaxis

Research Articles on CCR8

1. CCL1-CCR8 interaction may play a critical role in lymphocytic recruitment in IgG4-related sclerosing cholangitis and type 1 autoimmune pancreatitis, leading to duct-centred inflammation and obliterative phlebitis.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CCR8 antibody

Reference Product	PubMed Publications
CCL1 antibody	>101 publications with CCR8 and CCL1
CCL17 antibody	>34 publications with CCR8 and CCL17
CCL5 antibody	>24 publications with CCR8 and CCL5
CCL4 antibody	>24 publications with CCR8 and CCL4
CXCL10 antibody	>15 publications with CCR8 and CXCL10
CXCL9 antibody	>8 publications with CCR8 and CXCL9
CCL16 antibody	>8 publications with CCR8 and CCL16
CCL20 antibody	>7 publications with CCR8 and CCL20
CXCL11 antibody	>4 publications with CCR8 and CXCL11
CCL21 antibody	>1 publications with CCR8 and CCL21

Pathways associated with anti-CCR8 antibody

Products by Pathway	Pathway Diagram
Chemokine Receptors Bind Chemokines Pathway antibodies	Chemokine Receptors Bind Chemokines Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Chemokine Signaling Pathway antibodies	Chemokine Signaling Pathway Diagram
Class A/1 (Rhodopsin-like Receptors) Pathway antibodies	Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies	Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
Disease Pathway antibodies	Disease Pathway Diagram
G Alpha (i) Signalling Events Pathway antibodies	G Alpha (i) Signalling Events Pathway Diagram
GPCR Downstream Signaling Pathway antibodies	GPCR Downstream Signaling Pathway Diagram

Diseases associated with anti-CCR8 antibody

Disease Name	Pubmed Publications
Immune System Diseases Antibodies	>111 publications with CCR8 and Immune System Diseases
Inflammation Antibodies	>75 publications with CCR8 and Inflammation
Respiratory Tract Diseases Antibodies	>38 publications with CCR8 and Respiratory Tract Diseases
Lung Diseases Antibodies	>36 publications with CCR8 and Lung Diseases
Disease Models, Animal Antibodies	>27 publications with CCR8 and Disease Models, Animal
Autoimmune Diseases Antibodies	>22 publications with CCR8 and Autoimmune Diseases
Necrosis Antibodies	>17 publications with CCR8 and Necrosis
Encephalomyelitis, Autoimmune, Experimental Antibodies	>6 publications with CCR8 and Encephalomyelitis, Autoimmune, Experimental
Hypersensitivity, Delayed Antibodies	>5 publications with CCR8 and Hypersensitivity, Delayed
Kidney Diseases Antibodies	>3 publications with CCR8 and Kidney Diseases

Organs/Tissues associated with anti-CCR8 antibody

Organ/Tissue Name	Pubmed Publications
Blood Antibodies	>189 publications with CCR8 and Blood