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GHRHR Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246719

GHRHR, a Growth Hormone-Releasing Hormone Receptor, is involved in the proliferation and differentiation of somatotrophic pituitary cells and in disease. The GHRH receptor stimulates growth hormone (GH) secretion and synthesis in the pituitary. Mutations in… More details

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Product Overview

Product Name
GHRHR, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human GHRHR
Product Gene Name
anti-GHRHR antibody
Product Synonym Names
Anti-GHRHR Antibody (aa351-400) IHC-plus; GHRHR; GHRFR; GRFR; IGHD1B; GRF receptor; GH-releasing hormone receptor; GHRH receptor; Ghrh-r; Human GHRHR
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
GHRHR Antibody detects endogenous levels of total GHRHR protein.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
47,402 Da
OMIM
gene 612781
3D Structure
ModBase 3D Structure for Q02643
Target Species
Human
Immunogen Description
Synthetic peptide from human GHRHR (aa351-400).
Immunogen
GHRHR antibody was raised against synthetic peptide from human GHRHR (aa351-400).
Antigen Modification
aa351-400

Product Categories/Family for anti-GHRHR antibody

Family: GPCR; Subfamily: Growth hormone releasing hormone
Applications Tested/Suitable for anti-GHRHR antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-GHRHR antibody
ELISA (1:1000), IF (1:100 - 1:500), IHC-P (5 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-GHRHR antibody

Anti-GHRHR antibody IHC of human kidney, tubules. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-GHRHR Polyclonal Antibody – Cat# MBS246719

Immunofluorescence (IF) of anti-GHRHR antibody

Immunofluorescence of HUVEC cells, using GHRHR Antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-GHRHR Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS246719

Western Blot (WB) of anti-GHRHR antibody

Western blot of extracts from LOVO cells, using GHRHR Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-GHRHR Polyclonal Antibody, Western Blot (WB) – Cat# MBS246719

Other Notes

Small volumes of anti-GHRHR antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GHRHR purchase

MBS246719 is an antibody targeting GHRHR. Also known as Rabbit Polyclonal (IgG) to Human GHRHR. Reactive in Human, Mouse, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GHRHR. It may not necessarily be applicable to this product.

NCBI GI #
58530851
NCBI GeneID
2692
NCBI Accession #
NP_000814.2
UniProt Primary Accession #
Q02643
UniProt Secondary Accession #
Q99863
UniProt Related Accession #
Q02643
GenBank Nucleotide #
NM_000823.3
NCBI Official Full Name
growth hormone-releasing hormone receptor
NCBI Official Synonym Full Names
growth hormone releasing hormone receptor
NCBI Official Symbol
GHRHR
NCBI Official Synonym Symbols
GRFR; GHRFR; IGHD1B
UniProt Protein Name
Growth hormone-releasing hormone receptor
UniProt Synonym Protein Names
Growth hormone-releasing factor receptor; GRF receptor; GRFR
Protein Family
Growth hormone-releasing hormone receptor
UniProt Gene Name
GHRHR
UniProt Synonym Gene Names
GHRH receptor; GRF receptor; GRFR
UniProt Entry Name
GHRHR_HUMAN
NCBI Protein Information
growth hormone-releasing hormone receptor; GRF receptor; GHRH receptor

NCBI Summary for GHRHR

This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010]
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UniProt Comments for GHRHR

GHRHR: Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B); also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. Belongs to the G-protein coupled receptor 2 family.

Protein type: Receptor, GPCR; GPCR, family 2; Membrane protein, multi-pass; Cell development/differentiation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 7p14

Cellular Component: nuclear outer membrane; cell surface; nuclear matrix; cytoplasm; integral to membrane; plasma membrane; nuclear inner membrane; secretory granule

Molecular Function: G-protein coupled receptor activity; protein binding; peptide hormone binding; growth factor binding; growth hormone-releasing hormone receptor activity

Biological Process: positive regulation of insulin-like growth factor receptor signaling pathway; lactation; regulation of protein metabolic process; adenylate cyclase activation; cell maturation; response to glucocorticoid stimulus; determination of adult life span; positive regulation of multicellular organism growth; reproductive process in a multicellular organism; G-protein signaling, adenylate cyclase activating pathway; response to insulin stimulus; positive regulation of growth hormone secretion; water homeostasis; growth hormone secretion; cAMP-mediated signaling; cellular response to insulin stimulus; response to estrogen stimulus; positive regulation of cell proliferation; positive regulation of cAMP biosynthetic process; somatotropin secreting cell development; hormone metabolic process; regulation of steroid hormone receptor signaling pathway

Disease: Isolated Growth Hormone Deficiency, Type Ib
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Research Articles on GHRHR

1. These preliminary results suggest a greater than average GHRH-R expression in invasive lobular carcinomas and invasive ductal carcinomas associated with casting-type calcifications on the mammogram.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GHRHR antibody

 Reference Product  PubMed Publications
 GHRH antibody  >57 publications with GHRHR and GHRH

Pathways associated with anti-GHRHR antibody

 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 GPCRs, Other Pathway antibodies  GPCRs, Other Pathway Diagram
 Glucagon-type Ligand Receptors Pathway antibodies  Glucagon-type Ligand Receptors Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram

Diseases associated with anti-GHRHR antibody

 Disease Name  Pubmed Publications
 Isolated Growth Hormone Deficiency, Type IB Antibodies  >12 publications with GHRHR and Isolated Growth Hormone Deficiency, Type IB
 Breast Neoplasms Antibodies  >4 publications with GHRHR and Breast Neoplasms
 Weight Loss Antibodies  >3 publications with GHRHR and Weight Loss
 Cardiovascular Diseases Antibodies  >2 publications with GHRHR and Cardiovascular Diseases
 Heart Diseases Antibodies  >2 publications with GHRHR and Heart Diseases
 Kidney Neoplasms Antibodies  >1 publications with GHRHR and Kidney Neoplasms
 Liver Diseases Antibodies  >1 publications with GHRHR and Liver Diseases
 Prostatic Diseases Antibodies  >1 publications with GHRHR and Prostatic Diseases
 Weight Gain Antibodies  >1 publications with GHRHR and Weight Gain
 Necrosis Antibodies  >1 publications with GHRHR and Necrosis
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