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MMP11 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246734

MBS246734 is an antibody targeting MMP11. Also known as Rabbit Polyclonal (IgG) to Human MMP11. Reactive in Human, Mouse, Rat. Host: Rabbit. MMP11 is a Metallopeptidase M10A type protease. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MMP11, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human MMP11
Product Gene Name
Product Synonym Names
Anti-MMP11 Antibody (aa61-110) IHC-plus; MMP11; SL-3; Stromelysin III; Matrix metalloproteinase-11; MMP-11; ST3; STMY3; Stromelysin-3; Human MMP11
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
MMP-11 Antibody detects endogenous levels of total MMP-11 protein.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles.
Molecular Weight
54,590 Da
OMIM
185261
3D Structure
ModBase 3D Structure for P24347
Target Species
Human
Immunogen Description
Synthetic peptide from human MMP-11 (aa61-110).
Immunogen
MMP11 antibody was raised against synthetic peptide from human MMP-11 (aa61-110).
Antigen Modification
aa61-110
Applications Tested/Suitable for anti-MMP11 antibody
Immunohistochemistry (IHC - Paraffin), Immunofluorescence (IF), Western Blot (WB), ELISA (EIA)
Application Notes for anti-MMP11 antibody
ELISA (1:20000), IF (1:100 - 1:500), IHC-P (10 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-MMP11 antibody

Anti-MMP11 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-MMP11 Polyclonal Antibody – Cat# MBS246734

Immunohistochemistry (IHC) of anti-MMP11 antibody

Anti-MMP11 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-MMP11 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246734

Immunofluorescence (IF) of anti-MMP11 antibody

Immunofluorescence of A549 cells, using MMP-11 Antibody. The picture on the right is treated with the synthesized peptide.
Rabbit Anti-MMP11 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS246734

Western Blot (WB) of anti-MMP11 antibody

Western blot of extracts from A549 cells, using MMP-11 Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-MMP11 Polyclonal Antibody, Western Blot (WB) – Cat# MBS246734

Other Notes

Small volumes of anti-MMP11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for MMP11. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
stromelysin-3 preproprotein
NCBI Official Synonym Full Names
matrix metallopeptidase 11 (stromelysin 3)
NCBI Official Symbol
MMP11
NCBI Official Synonym Symbols
ST3; SL-3; STMY3
UniProt Protein Name
Stromelysin-3
UniProt Synonym Protein Names
Matrix metalloproteinase-11; MMP-11
Protein Family
UniProt Gene Name
MMP11
UniProt Synonym Gene Names
STMY3; SL-3; ST3; MMP-11
UniProt Entry Name
MMP11_HUMAN
NCBI Protein Information
stromelysin-3; MMP-11; stromelysin III

NCBI Summary for MMP11

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
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UniProt Comments for MMP11

MMP11: May play an important role in the progression of epithelial malignancies. Belongs to the peptidase M10A family.

Protein type: Extracellular matrix; EC 3.4.24.-; Secreted, signal peptide; Protease; Secreted

Chromosomal Location of Human Ortholog: 22q11.23

Cellular Component: proteinaceous extracellular matrix; Golgi lumen; extracellular region

Molecular Function: zinc ion binding; metalloendopeptidase activity; calcium ion binding

Biological Process: extracellular matrix disassembly; collagen catabolic process; extracellular matrix organization and biogenesis; collagen fibril organization; multicellular organismal development; negative regulation of fat cell differentiation; proteolysis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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