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CDX2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246754

MBS246754 is an antibody targeting CDX2. Also known as Rabbit Polyclonal to Human CDX2. Reactive in Bovine, Horse, Human, Monkey, Mouse, Opossum, Rat. Host: Rabbit. More details

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
CDX2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human CDX2
Product Gene Name
anti-CDX2 antibody
Product Synonym Names
Anti-CDX2 Antibody (aa1-60) IHC-plus; CDX2; Caudal-type homeobox protein 2; CDX3; Homeobox protein CDX-2; Caudal type homeobox 2; CDX-3; Human CDX2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Bovine, Horse, Human, Monkey, Mouse, Opossum, Rat
Form/Format
PBS, 0.05% BSA, 0.05% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human CDX2
Preparation and Storage
Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.
Molecular Weight
33,520 Da
OMIM
600297
3D Structure
ModBase 3D Structure for Q99626
Target Species
Human
Immunogen Description
A portion of amino acids 1-60 of human CDX3/CDX2 was used as the immunogen.
Immunogen Type
Synthetic peptide
Immunogen
CDX2 antibody was raised against a portion of amino acids 1-60 of human CDX3/CDX2 was used as the immunogen.
Antigen Modification
aa1-60
Applications Tested/Suitable for anti-CDX2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-CDX2 antibody
IHC-P (10 ug/ml), WB (1 - 3 ug/ml)

Immunohistochemistry (IHC) of anti-CDX2 antibody

Anti-CDX2 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Rabbit Anti-CDX2 Polyclonal Antibody – Cat# MBS246754

Immunohistochemistry (IHC) of anti-CDX2 antibody

Anti-CDX2 antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 10 ug/ml.
Rabbit Anti-CDX2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246754

Western Blot (WB) of anti-CDX2 antibody

Western blot of CDX3/CDX2 in HCT-116 cell lysate in the 1) absence and 2) presence of immunizing peptide using at 2 ug/ml. Goat anti-rabbit Ig HRP secondary antibody, and PicoTect ECL substrate solution, were used for this test.
Rabbit Anti-CDX2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS246754

Other Notes

Small volumes of anti-CDX2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CDX2. It may not necessarily be applicable to this product.

NCBI GI #
169636435
NCBI GeneID
1045
NCBI Accession #
NP_001256.2
UniProt Primary Accession #
Q99626
UniProt Secondary Accession #
O00503; Q5VTU7; Q969L8; Q9UD92
UniProt Related Accession #
Q99626
GenBank Nucleotide #
NM_001265.3
NCBI Official Full Name
homeobox protein CDX-2
NCBI Official Synonym Full Names
caudal type homeobox 2
NCBI Official Symbol
CDX2
NCBI Official Synonym Symbols
CDX3; CDX-3; CDX2/AS
UniProt Protein Name
Homeobox protein CDX-2
UniProt Synonym Protein Names
CDX-3; Caudal-type homeobox protein 2
Protein Family
Homeobox protein
UniProt Gene Name
CDX2
UniProt Synonym Gene Names
CDX3
UniProt Entry Name
CDX2_HUMAN
NCBI Protein Information
homeobox protein CDX-2; caudal-type homeobox protein 2; caudal type homeobox transcription factor 2; caudal type homeo box transcription factor 2

NCBI Summary for CDX2

This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded protein is a major regulator of intestine-specific genes involved in cell growth an differentiation. This protein also plays a role in early embryonic development of the intestinal tract. Aberrant expression of this gene is associated with intestinal inflammation and tumorigenesis. [provided by RefSeq, Jan 2012]
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UniProt Comments for CDX2

CDX2: Involved in the transcriptional regulation of multiple genes expressed in the intestinal epithelium. Important in broad range of functions from early differentiation to maintenance of the intestinal epithelial lining of both the small and large intestine. Belongs to the Caudal homeobox family.

Protein type: DNA-binding; Transcription factor

Chromosomal Location of Human Ortholog: 13q12.3

Cellular Component: nucleoplasm; condensed nuclear chromosome; transcriptional repressor complex

Molecular Function: double-stranded DNA binding; transcription factor activity; transcription corepressor activity

Biological Process: transcription from RNA polymerase II promoter; anterior/posterior pattern formation; establishment and/or maintenance of epithelial cell polarity; blood vessel development; organ morphogenesis; somatic stem cell maintenance; positive regulation of transcription, DNA-dependent; positive regulation of cell proliferation; endosome to lysosome transport; negative regulation of transcription from RNA polymerase II promoter; positive regulation of cell differentiation; trophectodermal cell differentiation
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Research Articles on CDX2

1. With follow up, we could not confirm that CDX2 expression had a prognostic significance.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CDX2 antibody

 Reference Product  PubMed Publications
 GATA4 antibody  >34 publications with CDX2 and GATA4
 KLF4 antibody  >20 publications with CDX2 and KLF4
 FGF4 antibody  >17 publications with CDX2 and FGF4
 CDK2 antibody  >6 publications with CDX2 and CDK2
 MAPK1 antibody  >4 publications with CDX2 and MAPK1
 FURIN antibody  >2 publications with CDX2 and FURIN

Pathways associated with anti-CDX2 antibody

 Products by Pathway  Pathway Diagram
 Incretin Synthesis, Secretion, And Inactivation Pathway antibodies  Incretin Synthesis, Secretion, And Inactivation Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 Peptide Hormone Metabolism Pathway antibodies  Peptide Hormone Metabolism Pathway Diagram
 Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway antibodies  Synthesis, Secretion, And Inactivation Of Glucagon-like Peptide-1 (GLP-1) Pathway Diagram

Diseases associated with anti-CDX2 antibody

 Disease Name  Pubmed Publications
 Carcinoma Antibodies  >505 publications with CDX2 and Carcinoma
 Stomach Neoplasms Antibodies  >175 publications with CDX2 and Stomach Neoplasms
 Colonic Neoplasms Antibodies  >138 publications with CDX2 and Colonic Neoplasms
 Neoplasm Metastasis Antibodies  >84 publications with CDX2 and Neoplasm Metastasis
 Lung Neoplasms Antibodies  >71 publications with CDX2 and Lung Neoplasms
 Liver Neoplasms Antibodies  >69 publications with CDX2 and Liver Neoplasms
 Head and Neck Neoplasms Antibodies  >65 publications with CDX2 and Head and Neck Neoplasms
 Ovarian Neoplasms Antibodies  >48 publications with CDX2 and Ovarian Neoplasms
 Inflammation Antibodies  >48 publications with CDX2 and Inflammation
 Carcinoma, Squamous Cell Antibodies  >36 publications with CDX2 and Carcinoma, Squamous Cell

Organs/Tissues associated with anti-CDX2 antibody

 Organ/Tissue Name  Pubmed Publications
 Intestine Antibodies  >384 publications with CDX2 and Intestine
 Liver Antibodies  >119 publications with CDX2 and Liver
 Embryonic Tissue Antibodies  >83 publications with CDX2 and Embryonic Tissue
 Ascites Antibodies  >5 publications with CDX2 and Ascites
 Uncharacterized Tissue Antibodies  >2 publications with CDX2 and Uncharacterized Tissue
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