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STEAP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246799

Stamp1/Steap2 is highly expressed in prostate. It is localized to the Golgi complex, predominantly to the trans-Golgi network and to the plasma membrane. It is thought to play and important role in normal prostate and in prostate cancer progression as it… More details

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Product Overview

Online Datasheet in PDF
Product Name
STEAP2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human STEAP2
Product Gene Name
Product Synonym Names
Anti-STEAP2 Antibody (Internal) IHC-plus; STEAP2; IPCA-1; PCANAP1; IPCA1; PUMPCn; STAMP1; STMP; Metalloreductase STEAP2; Human STEAP2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Bat, Gibbon, Chimpanzee, Dog, Guinea pig, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Rabbit, Rat
Predicted Reactivity: Bovine, Pig, Chicken, Zebrafish (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
0.8 mg/ml (lot specific)
Specificity
Human STEAP2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
47,916 Da
OMIM
605094
3D Structure
ModBase 3D Structure for Q8NFT2
Target Species
Human
Immunogen Description
Synthetic 15 amino acid peptide from internal region of human STEAP2. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Galago, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bat.
Immunogen Type
Synthetic peptide
Immunogen
STEAP2 antibody was raised against synthetic 15 amino acid peptide from internal region of human STEAP2. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Baboon, Monkey, Galago, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Bat, Dog, Rabbit, Horse, Opossum, Guinea pig, Armadillo, Platypus (100%); Bovine, Pig, Turkey, Chicken, Zebrafish (93%); Shrew, Zebra finch, Xenopus (87%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-STEAP2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-STEAP2 antibody
IHC-P (10 ug/ml)
Usage: Immunohistochemistry: was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in pH 6.0 citrate buffer. After incubation with the primary anti...

Immunohistochemistry (IHC) of anti-STEAP2 antibody

Anti-STEAP2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-STEAP2 Polyclonal Antibody – Cat# MBS246799

Immunohistochemistry (IHC) of anti-STEAP2 antibody

Anti-STEAP2 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-STEAP2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246799

Other Notes

Small volumes of anti-STEAP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for STEAP2 purchase

MBS246799 is an antibody targeting STEAP2. Also known as Rabbit Polyclonal to Human STEAP2. Reactive in Bat, Gibbon, Chimpanzee, Dog, Guinea pig, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Rabbit, Rat
Predicted Reactivity: Bovine, Pig, Chicken, Zebrafish (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for STEAP2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
metalloreductase STEAP2 isoform a
NCBI Official Synonym Full Names
STEAP family member 2, metalloreductase
NCBI Official Symbol
STEAP2
NCBI Official Synonym Symbols
STMP; IPCA1; PUMPCn; STAMP1; PCANAP1
UniProt Protein Name
Metalloreductase STEAP2
UniProt Synonym Protein Names
Prostate cancer-associated protein 1; Protein up-regulated in metastatic prostate cancer; PUMPCn; Six-transmembrane epithelial antigen of prostate 2; SixTransMembrane protein of prostate 1
Protein Family
UniProt Gene Name
STEAP2
UniProt Synonym Gene Names
PCANAP1; STAMP1; PUMPCn
UniProt Entry Name
STEA2_HUMAN
NCBI Protein Information
metalloreductase STEAP2; prostate cancer associated protein 1; prostate cancer-associated protein 1; SixTransMembrane Protein of Prostate 1; protein upregulated in metastatic prostate cancer; protein up-regulated in metastatic prostate cancer; six transmembrane epithelial antigen of prostate 2; six-transmembrane epithelial antigen of prostate 2; six transmembrane epithelial antigen of the prostate 2

NCBI Summary for STEAP2

This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
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UniProt Comments for STEAP2

STEAP2: Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Belongs to the STEAP family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Oxidoreductase; EC 1.16.1.-; Membrane protein, multi-pass; Membrane protein, integral; Vesicle

Chromosomal Location of Human Ortholog: 7q21.13

Cellular Component: trans-Golgi network transport vesicle; intracellular membrane-bound organelle; early endosome; plasma membrane; integral to Golgi membrane; endosome membrane; cytosol

Molecular Function: transporter activity; metal ion binding; cupric reductase activity

Biological Process: Golgi to plasma membrane transport; regulated secretory pathway; iron ion homeostasis; response to hormone stimulus; copper ion import; endocytosis
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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