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NPTN Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246801

This gene encodes a type I transmembrane protein belonging to the Ig superfamily. The protein is believed to be involved in cell-cell interactions or cell-substrate interactions. Alternative splicing results in multiple transcript variants. More details

$650 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
NPTN / SDR1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human NPTN / SDR1
Product Gene Name
anti-NPTN antibody
Product Synonym Gene Name
SDR1
Product Synonym Names
Anti-NPTN / SDR1 Antibody (Internal) IHC-plus; NPTN; gp65; gp55; Np55; Np65; SDR-1; SDR1; Neuroplastin; SDFR1; Human NPTN; SDR1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Bat, Gibbon, Bovine, Chimpanzee, Dog, Guinea pig, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human NPTN. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
43,931 Da
OMIM
612820
3D Structure
ModBase 3D Structure for Q9Y639
Target Species
Human
Immunogen Description
Synthetic 19 amino acid peptide from internal region of human NPTN.
Immunogen Type
Synthetic peptide
Immunogen
NPTN / SDR1 antibody was raised against synthetic 19 amino acid peptide from internal region of human NPTN. Percent identity with other species by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey, Galago, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bat, Bovine, Horse, Rabbit, Pig, Guinea pig (100%); Opossum, Turkey, Zebra finch, Chicken, Platypus, Lizard (89%); Salmon, Stickleback, Pufferfish (84%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-NPTN antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-NPTN antibody
IHC-P (15 - 20 ug/ml)

Immunohistochemistry (IHC) of anti-NPTN antibody

Anti-NPTN antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-NPTN Polyclonal Antibody – Cat# MBS246801

Immunohistochemistry (IHC) of anti-NPTN antibody

Anti-NPTN antibody IHC of human breast. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-NPTN Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246801

Other Notes

Small volumes of anti-NPTN antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NPTN purchase

MBS246801 is an antibody targeting NPTN. Also known as Rabbit Polyclonal to Human NPTN / SDR1. Reactive in Bat, Gibbon, Bovine, Chimpanzee, Dog, Guinea pig, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NPTN. It may not necessarily be applicable to this product.

NCBI GI #
6912646
NCBI GeneID
27020
NCBI Accession #
NP_036560.1
UniProt Primary Accession #
Q9Y639
UniProt Secondary Accession #
Q17R52; Q59EJ9; Q6NVX7; Q9Y640; B2RAL7; B7Z4D3; B7ZLL2
UniProt Related Accession #
Q9Y639
GenBank Nucleotide #
NM_012428.3
NCBI Official Full Name
neuroplastin isoform b
NCBI Official Synonym Full Names
neuroplastin
NCBI Official Symbol
NPTN
NCBI Official Synonym Symbols
GP55; GP65; SDR1; np55; np65; SDFR1
UniProt Protein Name
Neuroplastin
UniProt Synonym Protein Names
Stromal cell-derived receptor 1; SDR-1
Protein Family
Neuroplastin
UniProt Gene Name
NPTN
UniProt Synonym Gene Names
SDFR1; SDR1; SDR-1
UniProt Entry Name
NPTN_HUMAN
NCBI Protein Information
neuroplastin; SDR-1; stromal cell-derived receptor 1; stromal cell derived factor receptor 1

UniProt Comments for NPTN

neuroplastin: Probable homophilic and heterophilic cell adhesion molecule involved in long term potentiation at hippocampal excitatory synapses through activation of p38MAPK. May also regulate neurite outgrowth by activating the FGFR1 signaling pathway. May play a role in synaptic plasticity. 5 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Cell development/differentiation

Chromosomal Location of Human Ortholog: 15q22

Cellular Component: presynaptic membrane; cell surface; integral to membrane

Molecular Function: transmembrane receptor protein tyrosine kinase activity; cell adhesion molecule binding; ATP binding; type 1 fibroblast growth factor receptor binding

Biological Process: elevation of cytosolic calcium ion concentration; peptidyl-tyrosine phosphorylation; positive regulation of fibroblast growth factor receptor signaling pathway; positive regulation of protein amino acid phosphorylation; homophilic cell adhesion; positive regulation of long-term neuronal synaptic plasticity; transmembrane receptor protein tyrosine kinase signaling pathway
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Research Articles on NPTN

1. correct synaptic membrane protein localization, neuronal energy supply, expression of LTP and LTD, animal and human behaviour, and pathophysiology and disease--{review}

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-NPTN antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >5 publications with NPTN and Brain
 Blood Antibodies  >2 publications with NPTN and Blood
 Lymph Node Antibodies  >1 publications with NPTN and Lymph Node
 Lymph Antibodies  >1 publications with NPTN and Lymph
 Vascular Antibodies  >1 publications with NPTN and Vascular
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