Rabbit Anti-NR5A1 Polyclonal Antibody – Cat# MBS246808

Anti-NR5A1 antibody IHC of human ovary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

NR5A1 Antibody – Rabbit Polyclonal

Name: NR5A1 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS246808
Price: 630 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246808

Steroidogenic factor 1 (SF-1), a NR5 Fushi Tarazu-Like Receptor, has been shown to affect sexual differentiation, steroid metabolism, and neural development. SF-1 binds as a monomer and regulates all steroidogenic p450 genes, Mullerian inhibiting substance,… More details

$630 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

NR5A1 / SF1, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human NR5A1 / SF1

Product Gene Name

anti-NR5A1 antibody

Product Synonym Gene Name

SF1

Product Synonym Names

Anti-NR5A1 / SF1 Antibody (Internal) IHC-plus; NR5A1; AD4BP; Adrenal 4 binding protein; Adrenal 4-binding protein; ELP; Steroidogenic factor-1; SRXY3; Steroidogenic factor 1; Nuclear receptor AdBP4; Nuclear receptor elp; POF7; SF-1; SPGF8; Steroid hormone receptor Ad4BP; STF-1; FTZ1; FTZF1; Human NR5A1; SF1

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Bat, Gibbon, Gorilla, Human, Monkey
Predicted Reactivity: Bovine, Dog, Horse, Pig, Rabbit (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human NR5A1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TRIM23 (47%).

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

51,636 Da

OMIM

phenotype 613957

3D Structure

ModBase 3D Structure for Q13285

Target Species

Human

Immunogen Description

Synthetic 17 amino acid peptide from internal region of human NR5A1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bat (100%); Elephant, Panda, Dog, Bovine, Rabbit, Horse, Pig (94%).

Immunogen Type

Synthetic peptide

Immunogen

NR5A1 / SF1 antibody was raised against synthetic 17 amino acid peptide from internal region of human NR5A1. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Bat (100%); Elephant, Panda, Dog, Bovine, Rabbit, Horse, Pig (94%); Mouse, Rat, Hamster (88%); Turkey, Chicken, Platypus, Xenopus (82%).

Antigen Modification

Internal

Product Categories/Family for anti-NR5A1 antibody

Family: NHR; Subfamily: NR5 Fushi tarazu-like

Applications Tested/Suitable for anti-NR5A1 antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-NR5A1 antibody

IHC-P (2 - 18 ug/ml)

Other Notes

Small volumes of anti-NR5A1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for NR5A1 purchase

MBS246808 is an antibody targeting NR5A1. Also known as Rabbit Polyclonal to Human NR5A1 / SF1. Reactive in Bat, Gibbon, Gorilla, Human, Monkey
Predicted Reactivity: Bovine, Dog, Horse, Pig, Rabbit (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for NR5A1. It may not necessarily be applicable to this product.

NCBI GI #

20070193

NCBI GeneID

2516

NCBI Accession #

NP_004950.2

UniProt Primary Accession #

Q13285

UniProt Secondary Accession #

O15196; Q5T6F5

UniProt Related Accession #

Q13285

GenBank Nucleotide #

NM_004959.4

NCBI Official Full Name

steroidogenic factor 1

NCBI Official Synonym Full Names

nuclear receptor subfamily 5, group A, member 1

NCBI Official Symbol

NR5A1

NCBI Official Synonym Symbols

ELP; SF1; FTZ1; POF7; SF-1; AD4BP; FTZF1; SPGF8; SRXY3

UniProt Protein Name

Steroidogenic factor 1

UniProt Synonym Protein Names

Adrenal 4-binding protein; Fushi tarazu factor homolog 1; Nuclear receptor subfamily 5 group A member 1; Steroid hormone receptor Ad4BP

Protein Family

Steroidogenic factor

UniProt Gene Name

NR5A1

UniProt Synonym Gene Names

AD4BP; FTZF1; SF1; SF-1; STF-1

UniProt Entry Name

STF1_HUMAN

NCBI Protein Information

steroidogenic factor 1; STF-1; nuclear receptor AdBP4; steroidogenic factor-1; adrenal 4 binding protein; adrenal 4-binding protein; fushi tarazu factor homolog 1; steroid hormone receptor Ad4BP; steroidogenic factor 1 nuclear receptor

NCBI Summary for NR5A1

The protein encoded by this gene is a transcriptional activator involved in sex determination. The encoded protein binds DNA as a monomer. Defects in this gene are a cause of XY sex reversal with or without adrenal failure as well as adrenocortical insufficiency without ovarian defect. [provided by RefSeq, Jul 2008]

UniProt Comments for NR5A1

STF-1: a nuclear hormone receptor of the NR5 subfamily. Essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P-450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the Muellerian inhibiting substance (AMH) gene as well as the AHCH and STAR genes.

Protein type: Nuclear receptor

Chromosomal Location of Human Ortholog: 9q33

Cellular Component: nucleoplasm; nucleus

Molecular Function: RNA polymerase II transcription factor activity, enhancer binding; protein binding; ligand-dependent nuclear receptor activity; enzyme binding; DNA binding; zinc ion binding; sequence-specific DNA binding; double-stranded DNA binding; transcription coactivator activity; phospholipid binding; steroid hormone receptor activity; chromatin binding

Biological Process: tissue development; transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; adrenal gland development; primary sex determination; male gonad development; multicellular organismal aging; regulation of steroid biosynthetic process; cell-cell signaling; luteinization; hormone metabolic process; gene expression; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; maintenance of protein localization in nucleus; cell differentiation

Disease: Premature Ovarian Failure 7; 46,xy Sex Reversal 3; Spermatogenic Failure 8

Research Articles on NR5A1

1. Data suggest levels of steroidogenic factor 1/AD4BP/NR5A1 in subcapsular zone of adrenal glands (zona glomerulosa) are not different in subjects with primary aldosteronism, with aldosterone-producing adrenocortical adenomas, or normal subjects.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NR5A1 antibody

Reference Product	PubMed Publications
NR0B1 antibody	>75 publications with NR5A1 and NR0B1
SP1 antibody	>18 publications with NR5A1 and SP1
FOXL2 antibody	>16 publications with NR5A1 and FOXL2
TRERF1 antibody	>5 publications with NR5A1 and TRERF1
ESR1 antibody	>3 publications with NR5A1 and ESR1
NR0B2 antibody	>2 publications with NR5A1 and NR0B2
GNRH1 antibody	>1 publications with NR5A1 and GNRH1

Pathways associated with anti-NR5A1 antibody

Products by Pathway	Pathway Diagram
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Generic Transcription Pathway antibodies	Generic Transcription Pathway Diagram
Nuclear Receptor Transcription Pathway antibodies	Nuclear Receptor Transcription Pathway Diagram
Nuclear Receptors Pathway antibodies	Nuclear Receptors Pathway Diagram
Ovarian Infertility Genes Pathway antibodies	Ovarian Infertility Genes Pathway Diagram
Transcriptional Regulation Of Pluripotent Stem Cells Pathway antibodies	Transcriptional Regulation Of Pluripotent Stem Cells Pathway Diagram
Wnt Signaling Pathway NetPath antibodies	Wnt Signaling Pathway NetPath Diagram

Diseases associated with anti-NR5A1 antibody

Disease Name	Pubmed Publications
Disorders of Sex Development Antibodies	>81 publications with NR5A1 and Disorders of Sex Development
Urogenital Abnormalities Antibodies	>73 publications with NR5A1 and Urogenital Abnormalities
46, XY Disorders of Sex Development Antibodies	>50 publications with NR5A1 and 46, XY Disorders of Sex Development
Adrenal Insufficiency Antibodies	>48 publications with NR5A1 and Adrenal Insufficiency
Gonadal Dysgenesis, 46,XY Antibodies	>42 publications with NR5A1 and Gonadal Dysgenesis, 46,XY
Carcinoma Antibodies	>36 publications with NR5A1 and Carcinoma
Ovarian Diseases Antibodies	>36 publications with NR5A1 and Ovarian Diseases
Primary Ovarian Insufficiency Antibodies	>25 publications with NR5A1 and Primary Ovarian Insufficiency
Genital Diseases, Male Antibodies	>25 publications with NR5A1 and Genital Diseases, Male
Hypospadias Antibodies	>22 publications with NR5A1 and Hypospadias

Organs/Tissues associated with anti-NR5A1 antibody

Organ/Tissue Name	Pubmed Publications
Adrenal Gland Antibodies	>137 publications with NR5A1 and Adrenal Gland
Testis Antibodies	>123 publications with NR5A1 and Testis
Ovary Antibodies	>118 publications with NR5A1 and Ovary
Brain Antibodies	>62 publications with NR5A1 and Brain
Liver Antibodies	>52 publications with NR5A1 and Liver
Spleen Antibodies	>14 publications with NR5A1 and Spleen
Thymus Antibodies	>4 publications with NR5A1 and Thymus
Connective Tissue Antibodies	>2 publications with NR5A1 and Connective Tissue
Uncharacterized Tissue Antibodies	>1 publications with NR5A1 and Uncharacterized Tissue