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MRGD Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246837

MAS-related GPR, member D (MRGPRD), is expressed in the dorsal root ganglia and has been suggested to affect the modulation of neuropathic pain. More details

$650 / 0.05 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MRGD / MRGPRD, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human MRGD / MRGPRD
Product Gene Name
anti-MRGD antibody
Product Synonym Gene Name
MRGPRD
Product Synonym Names
Anti-MRGD / MRGPRD Antibody (Cytoplasmic Domain) IHC-plus; MRGPRD; Beta-alanine receptor; MRGD; MAS-related GPR; member D; TGR7; Human MRGD; MRGPRD
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gorilla, Human, Monkey
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human MRGPRD. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
36,118 Da
OMIM
607231
3D Structure
ModBase 3D Structure for Q8TDS7
Target Species
Human
Immunogen Description
Synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human MRGPRD. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Gibbon (89%); Marmoset (83%).
Immunogen Type
Synthetic peptide
Immunogen
MRGD / MRGPRD antibody was raised against synthetic 18 amino acid peptide from 3rd cytoplasmic domain of human MRGPRD. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Gibbon (89%); Marmoset (83%).
Antigen Modification
Cytoplasmic Domain

Product Categories/Family for anti-MRGD antibody

Family: GPCR; Subfamily: Orphan-A
Applications Tested/Suitable for anti-MRGD antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-MRGD antibody
IHC-P (17 ug/ml)

Immunohistochemistry (IHC) of anti-MRGD antibody

Anti-MRGPRD antibody IHC of human brain, medulla. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-MRGD Polyclonal Antibody – Cat# MBS246837

Immunohistochemistry (IHC) of anti-MRGD antibody

Anti-MRGD / MRGPRD antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-MRGD Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246837

Other Notes

Small volumes of anti-MRGD antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MRGD purchase

MBS246837 is an antibody targeting MRGD. Also known as Rabbit Polyclonal to Human MRGD / MRGPRD. Reactive in Gorilla, Human, Monkey. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MRGD. It may not necessarily be applicable to this product.

NCBI GI #
42794265
NCBI GeneID
116512
NCBI Accession #
NP_944605.2
UniProt Primary Accession #
Q8TDS7
UniProt Secondary Accession #
Q8NGK7
UniProt Related Accession #
Q8TDS7
GenBank Nucleotide #
NM_198923.2
NCBI Official Full Name
mas-related G-protein coupled receptor member D
NCBI Official Synonym Full Names
MAS-related GPR, member D
NCBI Official Symbol
MRGPRD
NCBI Official Synonym Symbols
MRGD; TGR7
UniProt Protein Name
Mas-related G-protein coupled receptor member D
UniProt Synonym Protein Names
Beta-alanine receptor; G-protein coupled receptor TGR7
UniProt Gene Name
MRGPRD
UniProt Synonym Gene Names
MRGD
UniProt Entry Name
MRGRD_HUMAN
NCBI Protein Information
mas-related G-protein coupled receptor member D; beta-alanine receptor; G-protein coupled receptor TGR7; mas-related G protein-coupled MRGD

UniProt Comments for MRGD

MRGPRD: May regulate nociceptor function and/or development, including the sensation or modulation of pain. Functions as a specific membrane receptor for beta-alanine. Beta-alanine at micromolar doses specifically evoked Ca(2+) influx in cells expressing the receptor. Beta-alanine decreases forskolin- stimulated cAMP production in cells expressing the receptor, suggesting that the receptor couples with G-protein G(q) and G(i). Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

Protein type: Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 11q13.3

Cellular Component: extracellular space; plasma membrane; integral to membrane

Molecular Function: G-protein coupled receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway
Show more

Research Articles on MRGD

1. Heptapeptide alamandine acts through Mas-related G-protein-coupled receptor member D producing physiological actions that resemble those generated by angiotensin-1-7.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MRGD antibody

 Reference Product  PubMed Publications
 TRPV1 antibody  >8 publications with MRGD and TRPV1
 TRPM8 antibody  >3 publications with MRGD and TRPM8

Diseases associated with anti-MRGD antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1 publications with MRGD and Inflammation
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