Goat Anti-CHD7 Polyclonal Antibody – Cat# MBS246843

Anti-CHD7 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.

CHD7 Antibody – Goat Polyclonal

Name: CHD7 Antibody; Polyclonal; Goat; MyBioSource
Brand: MyBioSource
SKU: MBS246843
Price: 625 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246843

MBS246843 is an antibody targeting CHD7. Also known as Goat Polyclonal to Human CHD7. Reactive in HumanPredicted Reactivity: Gorilla, Gibbon, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Pig, Chicken (at least 90% immunogen sequence identity). Host: Goat. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

CHD7, Polyclonal Antibody

Full Product Name

Goat Polyclonal to Human CHD7

Product Gene Name

anti-CHD7 antibody

Product Synonym Names

Anti-CHD7 Antibody (Internal) IHC-plus; CHD7; ATP-dependent helicase CHD7; HH5; KAL5; CHD-7; IS3; KIAA1416; Human CHD7

Clonality

Polyclonal

Host

Goat

Species Reactivity

Human
Predicted Reactivity: Gorilla, Gibbon, Monkey, Mouse, Rat, Bat, Bovine, Dog, Horse, Pig, Chicken (at least 90% immunogen sequence identity)

Form/Format

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

Purity/Purification

Immunoaffinity Purified

Concentration

0.5 mg/ml (lot specific)

Specificity

Human CHD7.

Preparation and Storage

Store at -20 degree C. Minimize freezing and thawing.

Molecular Weight

101,085 Da

OMIM

gene 612370

3D Structure

ModBase 3D Structure for Q9P2D1

Target Species

Human

Immunogen Description

Synthetic peptide C-KDEIDEFANSPSE from an internal region of human CHD7 (NP_060250.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (92%), Gibbon (92%), Monkey (92%), Marmoset (92%), Mouse (92%), Rat (92%).

Immunogen Type

Synthetic peptide

Immunogen

CHD7 antibody was raised against synthetic peptide C-KDEIDEFANSPSE from an internal region of human CHD7 (NP_060250.2). Percent identity with other species by BLAST analysis: Human (100%), Gorilla (92%), Gibbon (92%), Monkey (92%), Marmoset (92%), Mouse (92%), Rat (92%), Elephant (92%), Panda (92%), Bovine (92%), Dog (92%), Bat (92%), Horse (92%), Pig (92%), Opossum (92%), Turkey (92%), Chicken (92%), Lizard (92%), Rabbit (85%).

Antigen Modification

Internal

Applications Tested/Suitable for anti-CHD7 antibody

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

Application Notes for anti-CHD7 antibody

ELISA (1:64000), IHC-P (3.75 ug/ml)

Other Notes

Small volumes of anti-CHD7 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for CHD7. It may not necessarily be applicable to this product.

NCBI GI #

54112403

NCBI GeneID

55636

NCBI Accession #

NP_060250.2

UniProt Primary Accession #

Q9P2D1

UniProt Secondary Accession #

Q05DI5; Q2TAN4; Q66K35; Q7Z6C0; Q7Z7Q2; Q9NXA0; Q9NXA3; D0VBA5; E9PNZ2

UniProt Related Accession #

Q9P2D1

GenBank Nucleotide #

NM_017780.3

NCBI Official Full Name

chromodomain-helicase-DNA-binding protein 7

NCBI Official Synonym Full Names

chromodomain helicase DNA binding protein 7

NCBI Official Symbol

CHD7

NCBI Official Synonym Symbols

CRG; HH5; IS3; KAL5

UniProt Protein Name

Chromodomain-helicase-DNA-binding protein 7

UniProt Synonym Protein Names

ATP-dependent helicase CHD7

Protein Family

Chromodomain-helicase-DNA-binding protein

UniProt Gene Name

CHD7

UniProt Synonym Gene Names

KIAA1416; CHD-7

UniProt Entry Name

CHD7_HUMAN

NCBI Protein Information

chromodomain-helicase-DNA-binding protein 7; CHARGE association; ATP-dependent helicase CHD7; chromodomain helicase DNA binding protein 7 isoform CRA_e

NCBI Summary for CHD7

This gene encodes a protein that contains several helicase family domains. Mutations in this gene have been found in some patients with the CHARGE syndrome. [provided by RefSeq, Jul 2008]

UniProt Comments for CHD7

CHD-7: Probable transcription regulator. May interact with CTCF. Interacts with CHD8. Widely expressed in fetal and adult tissues. Belongs to the SNF2/RAD54 helicase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleolus; Helicase; DNA-binding; EC 3.6.4.12

Chromosomal Location of Human Ortholog: 8q12.2

Cellular Component: nucleoplasm; nucleolus; nucleus

Molecular Function: protein binding; DNA binding; chromatin binding; helicase activity; ATP binding

Biological Process: heart morphogenesis; limb development; central nervous system development; olfactory behavior; blood circulation; palate development; positive regulation of multicellular organism growth; regulation of growth hormone secretion; adult walking behavior; female genitalia development; embryonic hindlimb morphogenesis; olfactory nerve development; sensory perception of sound; regulation of neurogenesis; regulation of transcription, DNA-dependent; skeletal development; T cell differentiation; adult heart development; inner ear morphogenesis; transcription, DNA-dependent; in utero embryonic development; olfactory bulb development; semicircular canal morphogenesis; cranial nerve development; chromatin modification; genitalia development; retina development in camera-type eye; artery morphogenesis; cognition; nose development; rRNA processing

Disease: Charge Syndrome; Tracheoesophageal Fistula With Or Without Esophageal Atresia; Hypogonadotropic Hypogonadism 5 With Or Without Anosmia

Research Articles on CHD7

1. CHD7 was dysregulated, ranking above the 90th percentile in differential expression in a panel of PDAC clinical specimens, highlighting its potential as a biomarker.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CHD7 antibody

Reference Product	PubMed Publications
CHD8 antibody	>6 publications with CHD7 and CHD8
NLK antibody	>1 publications with CHD7 and NLK
SMARCA4 antibody	>1 publications with CHD7 and SMARCA4
SETDB1 antibody	>1 publications with CHD7 and SETDB1

Pathways associated with anti-CHD7 antibody

Products by Pathway	Pathway Diagram
Noncanonical Wnt Signaling Pathway antibodies	Noncanonical Wnt Signaling Pathway Diagram

Diseases associated with anti-CHD7 antibody

Disease Name	Pubmed Publications
CHARGE Syndrome Antibodies	>179 publications with CHD7 and CHARGE Syndrome
Heart Diseases Antibodies	>48 publications with CHD7 and Heart Diseases
Kallmann Syndrome Antibodies	>35 publications with CHD7 and Kallmann Syndrome
Idiopathic Hypogonadotropic Hypogonadism Antibodies	>8 publications with CHD7 and Idiopathic Hypogonadotropic Hypogonadism
Death Antibodies	>6 publications with CHD7 and Death
Fetal Growth Retardation Antibodies	>3 publications with CHD7 and Fetal Growth Retardation
Immune System Diseases Antibodies	>3 publications with CHD7 and Immune System Diseases
Infertility, Male Antibodies	>2 publications with CHD7 and Infertility, Male
Atrophy Antibodies	>2 publications with CHD7 and Atrophy
Ovarian Diseases Antibodies	>2 publications with CHD7 and Ovarian Diseases

Organs/Tissues associated with anti-CHD7 antibody

Organ/Tissue Name	Pubmed Publications
Heart Antibodies	>92 publications with CHD7 and Heart
Nerve Antibodies	>31 publications with CHD7 and Nerve
Brain Antibodies	>28 publications with CHD7 and Brain
Eye Antibodies	>27 publications with CHD7 and Eye
Bone Antibodies	>23 publications with CHD7 and Bone
Blood Antibodies	>13 publications with CHD7 and Blood
Embryonic Tissue Antibodies	>12 publications with CHD7 and Embryonic Tissue
Mouth Antibodies	>5 publications with CHD7 and Mouth
Thymus Antibodies	>4 publications with CHD7 and Thymus
Muscle Antibodies	>3 publications with CHD7 and Muscle