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EAR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246864

ErbA-related protein Ear-2, a NR2 Hepatocyte NF4-Like Receptor, has been shown to affect myeloid cell growth and differentiation, oxytocin expression in the uterus, aldehyde dehydrogenase 2 promoter function, human luteinizing hormone receptor transcription,… More details

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Product Overview

Online Datasheet in PDF
Product Name
EAR2 / NR2F6, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human EAR2 / NR2F6
Product Gene Name
anti-EAR2 antibody
Product Synonym Gene Name
NR2F6
Product Synonym Names
Anti-EAR2 / NR2F6 Antibody (Ligand-binding Domain) IHC-plus; NR2F6; Erba related 2; ERBAL2; EAR-2; EAR2; ERBA-related gene-2; V-erbA-related protein 2; Human EAR2; NR2F6
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Bat, Bovine, Dog, Xenopus, Gorilla, Hamster, Human, Monkey, Mouse, Pig, Rat, Zebrafish
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human NR2F6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
42,979 Da
OMIM
132880
3D Structure
ModBase 3D Structure for P10588
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from ligand-binding domain of human NR2F6.
Immunogen Type
Synthetic peptide
Immunogen
EAR2 / NR2F6 antibody was raised against synthetic 16 amino acid peptide from ligand-binding domain of human NR2F6. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey, Marmoset, Mouse, Rat, Hamster, Elephant, Panda, Dog, Bovine, Bat, Pig, Platypus, Xenopus, Stickleback, Pufferfish, Zebrafish (100%); Opossum (94%).
Antigen Modification
Ligand-binding Domain

Product Categories/Family for anti-EAR2 antibody

Family: NHR; Subfamily: NR2 Hepatocyte NF4-like
Applications Tested/Suitable for anti-EAR2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-EAR2 antibody
IHC-P (5 ug/ml)

Immunohistochemistry (IHC) of anti-EAR2 antibody

Anti-NR2F6 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-EAR2 Polyclonal Antibody – Cat# MBS246864

Immunohistochemistry (IHC) of anti-EAR2 antibody

Anti-EAR2 / NR2F6 antibody IHC of human Breast, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-EAR2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246864

Immunohistochemistry (IHC) of anti-EAR2 antibody

Anti-EAR2 / NR2F6 antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-EAR2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246864

Other Notes

Small volumes of anti-EAR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for EAR2 purchase

MBS246864 is an antibody targeting EAR2. Also known as Rabbit Polyclonal to Human EAR2 / NR2F6. Reactive in Bat, Bovine, Dog, Xenopus, Gorilla, Hamster, Human, Monkey, Mouse, Pig, Rat, Zebrafish. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for EAR2. It may not necessarily be applicable to this product.

NCBI GI #
20070199
NCBI GeneID
2063
NCBI Accession #
NP_005225.2
UniProt Primary Accession #
P10588
UniProt Secondary Accession #
Q5XGA0; Q6P586; Q9BUE8; B2RC68
UniProt Related Accession #
P10588
GenBank Nucleotide #
NM_005234.3
NCBI Official Full Name
nuclear receptor subfamily 2 group F member 6
NCBI Official Synonym Full Names
nuclear receptor subfamily 2, group F, member 6
NCBI Official Symbol
NR2F6
NCBI Official Synonym Symbols
EAR2; EAR-2; ERBAL2
UniProt Protein Name
Nuclear receptor subfamily 2 group F member 6
UniProt Synonym Protein Names
V-erbA-related protein 2; EAR-2
Protein Family
Eosinophil cationic protein
UniProt Gene Name
NR2F6
UniProt Synonym Gene Names
EAR2; ERBAL2; EAR-2
UniProt Entry Name
NR2F6_HUMAN
NCBI Protein Information
nuclear receptor subfamily 2 group F member 6; ERBA-related gene-2; V-erbA-related protein 2; nuclear receptor V-erbA-related; v-erb-a avian erythroblastic leukemia viral oncogene homolog-like 2

UniProt Comments for EAR2

EAR-2: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type- specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC). Belongs to the nuclear hormone receptor family. NR2 subfamily.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 19p13.1

Cellular Component: nucleoplasm; nucleus

Molecular Function: protein binding; ligand-dependent nuclear receptor activity; DNA binding; zinc ion binding; sequence-specific DNA binding; steroid hormone receptor activity; thyroid hormone receptor activity; transcription factor activity

Biological Process: transcription initiation from RNA polymerase II promoter; intracellular receptor-mediated signaling pathway; neuron development; gene expression; steroid hormone mediated signaling; negative regulation of transcription from RNA polymerase II promoter; detection of temperature stimulus involved in sensory perception of pain; signal transduction; entrainment of circadian clock by photoperiod
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Research Articles on EAR2

1. EAR2/NR2F6 and related NRs such as the COUPTFs, TLX and PNR can selectively associate with the developmental corepressor BCL11A via a conserved motif F/YSXXLXXL/Y within the RID1 and RID2 domains. The interaction with BCL11A facilitates COUP-TFII-mediated repression of the RARb2 gene.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-EAR2 antibody

 Reference Product  PubMed Publications
 NR1D1 antibody  >1 publications with EAR2 and NR1D1
 RASD1 antibody  >1 publications with EAR2 and RASD1

Pathways associated with anti-EAR2 antibody

 Products by Pathway  Pathway Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 Generic Transcription Pathway antibodies  Generic Transcription Pathway Diagram
 Nuclear Receptor Transcription Pathway antibodies  Nuclear Receptor Transcription Pathway Diagram
 Nuclear Receptors Pathway antibodies  Nuclear Receptors Pathway Diagram

Diseases associated with anti-EAR2 antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >3 publications with EAR2 and Inflammation
 Carcinoma Antibodies  >2 publications with EAR2 and Carcinoma
 Breast Neoplasms Antibodies  >2 publications with EAR2 and Breast Neoplasms
 Cardiovascular Diseases Antibodies  >1 publications with EAR2 and Cardiovascular Diseases
 Nervous System Diseases Antibodies  >1 publications with EAR2 and Nervous System Diseases
 Brain Diseases Antibodies  >1 publications with EAR2 and Brain Diseases
 Kidney Diseases Antibodies  >1 publications with EAR2 and Kidney Diseases
 Hyperplasia Antibodies  >1 publications with EAR2 and Hyperplasia

Organs/Tissues associated with anti-EAR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >7 publications with EAR2 and Brain
 Liver Antibodies  >4 publications with EAR2 and Liver
 Kidney Antibodies  >2 publications with EAR2 and Kidney
 Nerve Antibodies  >2 publications with EAR2 and Nerve
 Bone Antibodies  >2 publications with EAR2 and Bone
 Bone Marrow Antibodies  >1 publications with EAR2 and Bone Marrow
 Placenta Antibodies  >1 publications with EAR2 and Placenta
 Testis Antibodies  >1 publications with EAR2 and Testis
 Muscle Antibodies  >1 publications with EAR2 and Muscle
 Prostate Antibodies  >1 publications with EAR2 and Prostate
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