Goat Anti-SCNN1D Polyclonal Antibody – Cat# MBS246889

Anti-SCNN1D antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 2.5 ug/ml.

SCNN1D Antibody – Goat Polyclonal

Name: SCNN1D Antibody; Polyclonal; Goat; Human-Reactive; MyBioSource
Brand: MyBioSource
SKU: MBS246889
Price: 680 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246889

MBS246889 is an antibody targeting SCNN1D. Also known as Goat Polyclonal to Human SCNN1D. Reactive in Chimpanzee, HumanPredicted Reactivity: Gorilla, Gibbon, Monkey (at least 90% immunogen sequence identity). Host: Goat. More details

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Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Product Name

SCNN1D, Polyclonal Antibody

Full Product Name

Goat Polyclonal to Human SCNN1D

Product Gene Name

anti-SCNN1D antibody

Product Synonym Names

Anti-SCNN1D Antibody (C-Terminus) IHC-plus; SCNN1D; Delta-ENaC; Delta-NaCH; ENaCdelta; ENaCd; DNaCh; ENaC delta; SCNED; Human SCNN1D

Clonality

Polyclonal

Host

Goat

Species Reactivity

Chimpanzee, Human
Predicted Reactivity: Gorilla, Gibbon, Monkey (at least 90% immunogen sequence identity)

Form/Format

Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide

Purity/Purification

Immunoaffinity Purified

Concentration

0.5 mg/ml (lot specific)

Specificity

Human SCNN1D.

Preparation and Storage

Store at -20 degree C. Minimize freezing and thawing.

Molecular Weight

77,442 Da

OMIM

601328

3D Structure

ModBase 3D Structure for P51172

Target Species

Human

Immunogen Description

Synthetic peptide C-AGPQPLETLDT from the C-terminus of human SCNN1D (NP_002969.2). Percent identity by BLAST analysis: Human, Chimpanzee (100%); Gorilla, Gibbon, Monkey (91%).

Immunogen Type

Synthetic peptide

Immunogen

SCNN1D antibody was raised against synthetic peptide C-AGPQPLETLDT from the C-terminus of human SCNN1D (NP_002969.2). Percent identity by BLAST analysis: Human, Chimpanzee (100%); Gorilla, Gibbon, Monkey (91%).

Antigen Modification

C-Terminus

Product Categories/Family for anti-SCNN1D antibody

Family: Ion Channel; Subfamily: Sodium channel - amiloride-sensitive

Applications Tested/Suitable for anti-SCNN1D antibody

Immunohistochemistry (IHC - Paraffin), ELISA (EIA)

Application Notes for anti-SCNN1D antibody

ELISA (1:16000), IHC-P (2.5 - 3.75 ug/ml)
Usage: Peptide ELISA: antibody detection limit dilution 1:16000. Western blot: Preliminary experiments in Human Pancreas and Thymus lysates gave no specific signal but low background (at antibody concentration up to 1 ug/ml).

Other Notes

Small volumes of anti-SCNN1D antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for SCNN1D. It may not necessarily be applicable to this product.

NCBI GI #

34101282

NCBI GeneID

6339

NCBI Accession #

NP_002969.2

UniProt Primary Accession #

P51172

UniProt Secondary Accession #

Q08AQ3; Q09HT0; Q5T7L3; Q8NA24; A9Z1X6; B1PS44

UniProt Related Accession #

P51172

GenBank Nucleotide #

NM_002978.2

NCBI Official Synonym Full Names

sodium channel, non voltage gated 1 delta subunit

NCBI Official Symbol

SCNN1D

NCBI Official Synonym Symbols

ENaCd; SCNED; dNaCh; ENaCdelta

UniProt Protein Name

Amiloride-sensitive sodium channel subunit delta

UniProt Synonym Protein Names

Delta-NaCH; Epithelial Na(+) channel subunit delta; Delta-ENaC; ENaCD; Nonvoltage-gated sodium channel 1 subunit delta; SCNED

Protein Family

Amiloride-sensitive sodium channel

UniProt Gene Name

SCNN1D

UniProt Synonym Gene Names

DNACH; Delta-ENaC; ENaCD

UniProt Entry Name

SCNND_HUMAN

NCBI Protein Information

amiloride-sensitive sodium channel subunit delta

UniProt Comments for SCNN1D

ENaC-delta: Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family. SCNN1D subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Transporter, ion channel; Membrane protein, multi-pass; Membrane protein, integral; Channel, sodium

Chromosomal Location of Human Ortholog: 1p36.3-p36.2

Cellular Component: membrane; plasma membrane; integral to membrane; actin cytoskeleton

Molecular Function: amiloride-sensitive sodium channel activity; protein binding

Biological Process: sensory perception of taste; response to stimulus; sodium ion transport; transmembrane transport

Research Articles on SCNN1D

1. study characterized a new variant, delta2 ENaC, in lung epithelial cells; heterologous delta2betagamma ENaC exhibited a number of divergent features from the delta1betagamma counterpart in biophysics and pharmacology, regulation, and the lifespan of proteins

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-SCNN1D antibody

Reference Product	PubMed Publications
SCNN1G antibody	>4 publications with SCNN1D and SCNN1G
SCNN1B antibody	>4 publications with SCNN1D and SCNN1B

Pathways associated with anti-SCNN1D antibody

Products by Pathway	Pathway Diagram
Ion Channel Transport Pathway antibodies	Ion Channel Transport Pathway Diagram
Stimuli-sensing Channels Pathway antibodies	Stimuli-sensing Channels Pathway Diagram
Transmembrane Transport Of Small Molecules Pathway antibodies	Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-SCNN1D antibody

Disease Name	Pubmed Publications
Heart Diseases Antibodies	>1 publications with SCNN1D and Heart Diseases
Parkinson Disease Antibodies	>1 publications with SCNN1D and Parkinson Disease
Hypertension Antibodies	>1 publications with SCNN1D and Hypertension

Organs/Tissues associated with anti-SCNN1D antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>4 publications with SCNN1D and Brain
Heart Antibodies	>3 publications with SCNN1D and Heart
Lung Antibodies	>2 publications with SCNN1D and Lung
Bone Antibodies	>1 publications with SCNN1D and Bone
Kidney Antibodies	>1 publications with SCNN1D and Kidney
Ovary Antibodies	>1 publications with SCNN1D and Ovary
Pancreas Antibodies	>1 publications with SCNN1D and Pancreas
Testis Antibodies	>1 publications with SCNN1D and Testis