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DISPA Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246891

MBS246891 is an antibody targeting DISPA. Also known as Rabbit Polyclonal to Human DISPA / DISP1. Reactive in Human, Mouse. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
DISPA / DISP1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human DISPA / DISP1
Product Gene Name
Product Synonym Gene Name
DISP1
Product Synonym Names
Anti-DISPA / DISP1 Antibody (N-Terminus) IHC-plus; DISP1; DISPA; Dispatched A; DKFZP434I0428; Protein dispatched homolog 1; Human DISPA; DISP1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human DISP1. At least two isoforms of DISP1 are known to exist; this antibody will detect both isoforms. DISP1 antibody is predicted to not cross-react with EMX1.
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
170,934 Da
OMIM
607502
3D Structure
ModBase 3D Structure for Q96F81
Target Species
Human
Immunogen Description
A 16 amino acid peptide near the amino terminus of human DISP1
Immunogen Type
Synthetic peptide
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-DISPA antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-DISPA antibody
IHC-P (5 ug/ml), WB (1 - 2 ug/ml)

Immunohistochemistry (IHC) of anti-DISPA antibody

Anti-DISP1 / DISPA antibody IHC of human heart. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-DISPA Polyclonal Antibody – Cat# MBS246891

Immunohistochemistry (IHC) of anti-DISPA antibody

Anti-DISP1 / DISPA antibody IHC of human colon, submucosal plexus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-DISPA Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS246891

Immunofluorescence (IF) of anti-DISPA antibody

Immunofluorescence of DISP1 in human kidney tissue with DISP1 antibody at 20 ug/ml.
Rabbit Anti-DISPA Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS246891

Western Blot (WB) of anti-DISPA antibody

Western blot analysis of DISP1 in 3T3 cell lysate with DISP1 antibody at 1 ug/ml.
Rabbit Anti-DISPA Polyclonal Antibody, Western Blot (WB) – Cat# MBS246891

Other Notes

Small volumes of anti-DISPA antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DISPA. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
protein dispatched homolog 1
NCBI Official Synonym Full Names
dispatched homolog 1 (Drosophila)
NCBI Official Symbol
DISP1
NCBI Official Synonym Symbols
DISPA
UniProt Protein Name
Protein dispatched homolog 1
UniProt Gene Name
DISP1
UniProt Synonym Gene Names
DISPA
UniProt Entry Name
DISP1_HUMAN
NCBI Protein Information
protein dispatched homolog 1; dispatched A

NCBI Summary for DISPA

The pattern of cellular proliferation and differentiation that leads to normal development of embryonic structures often depends upon the localized production of secreted protein signals. Cells surrounding the source of a particular signal respond in a graded manner according to the effective concentration of the signal, and this response produces the pattern of cell types constituting the mature structure. A novel segment-polarity gene known as dispatched has been identified in Drosophila and its protein product is required for normal Hedgehog (Hh) signaling. This gene is one of two human homologs of Drosophila dispatched and, based on sequence identity to its mouse counterpart, the encoded protein may play an essential role in Hh patterning activities in the early embryo. [provided by RefSeq, Jul 2008]
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UniProt Comments for DISPA

DISP1: Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Belongs to the dispatched family.

Protein type: Membrane protein, multi-pass; Transporter; Membrane protein, integral

Chromosomal Location of Human Ortholog: 1q41

Cellular Component: integral to membrane

Molecular Function: peptide transporter activity; hedgehog receptor activity

Biological Process: peptide transport; smoothened signaling pathway; dorsal/ventral pattern formation; patched ligand processing; determination of left/right symmetry; embryonic pattern specification
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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