Rabbit Anti-GABRA3 Polyclonal Antibody – Cat# MBS246922

Anti-GABRA3 antibody IHC of human brain, basal nucleus of Meynert. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

GABRA3 Antibody – Rabbit Polyclonal

Name: GABRA3 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS246922
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246922

GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A… More details

$650 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

GABRA3, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human GABRA3

Product Gene Name

anti-GABRA3 antibody

Product Synonym Names

Anti-GABRA3 Antibody (N-Terminus) IHC-plus; GABRA3; GABA(A) receptor; alpha 3; GABA A receptor alpha 3; Human GABRA3

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Bat, Gibbon, Bovine, Dog, Gorilla, Horse, Human, Monkey, Mouse, Rabbit, Rat

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human GABRA3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

55,165 Da

OMIM

305660

3D Structure

ModBase 3D Structure for P34903

Target Species

Human

Immunogen Description

Synthetic 15 amino acid peptide from N-Terminus of human GABRA3. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Dog, Bat, Bovine, Horse, Rabbit (100%); Opossum, Platypus (87%).

Immunogen Type

Synthetic peptide

Immunogen

GABRA3 antibody was raised against synthetic 15 amino acid peptide from N-Terminus of human GABRA3. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Mouse, Rat, Elephant, Dog, Bat, Bovine, Horse, Rabbit (100%); Opossum, Platypus (87%).

Antigen Modification

N-Terminus

Product Categories/Family for anti-GABRA3 antibody

Family: Ion Channel; Subfamily: GABA A receptor

Applications Tested/Suitable for anti-GABRA3 antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-GABRA3 antibody

IHC-P (5 ug/ml)

Other Notes

Small volumes of anti-GABRA3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GABRA3 purchase

MBS246922 is an antibody targeting GABRA3. Also known as Rabbit Polyclonal to Human GABRA3. Reactive in Bat, Gibbon, Bovine, Dog, Gorilla, Horse, Human, Monkey, Mouse, Rabbit, Rat. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GABRA3. It may not necessarily be applicable to this product.

NCBI GI #

4557603

NCBI GeneID

2556

NCBI Accession #

NP_000799.1

UniProt Primary Accession #

P34903

UniProt Secondary Accession #

Q8TAF9

UniProt Related Accession #

P34903

GenBank Nucleotide #

NM_000808.3

NCBI Official Full Name

gamma-aminobutyric acid receptor subunit alpha-3

NCBI Official Synonym Full Names

gamma-aminobutyric acid (GABA) A receptor, alpha 3

NCBI Official Symbol

GABRA3

UniProt Protein Name

Gamma-aminobutyric acid receptor subunit alpha-3

UniProt Synonym Protein Names

GABA(A) receptor subunit alpha-3

Protein Family

Gamma-aminobutyric acid receptor

UniProt Gene Name

GABRA3

UniProt Entry Name

GBRA3_HUMAN

NCBI Protein Information

gamma-aminobutyric acid receptor subunit alpha-3; GABA(A) receptor, alpha 3; GABA(A) receptor subunit alpha-3; gamma-animobutyric acid (GABA) A receptor, alpha 3

UniProt Comments for GABRA3

GABRA3: GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA3 sub-subfamily.

Protein type: Transporter, ion channel; Membrane protein, integral; Transporter; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: Xq28

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: chloride channel activity; GABA-A receptor activity; benzodiazepine receptor activity; extracellular ligand-gated ion channel activity

Biological Process: synaptic transmission; transport; transmembrane transport; gamma-aminobutyric acid signaling pathway

Research Articles on GABRA3

1. high expression of GABBR2 with a low expression of GABR(A3) may predict a better outcome in non-small cell lung cancer

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GABRA3 antibody

Reference Product	PubMed Publications
GABRA2 antibody	>15 publications with GABRA3 and GABRA2
GABRA1 antibody	>12 publications with GABRA3 and GABRA1
GABRB3 antibody	>7 publications with GABRA3 and GABRB3
GABRA5 antibody	>5 publications with GABRA3 and GABRA5
GABRA6 antibody	>4 publications with GABRA3 and GABRA6
GABRA4 antibody	>3 publications with GABRA3 and GABRA4
GABRG2 antibody	>3 publications with GABRA3 and GABRG2
GABRB2 antibody	>2 publications with GABRA3 and GABRB2
GABRB1 antibody	>1 publications with GABRA3 and GABRB1
GABRG3 antibody	>1 publications with GABRA3 and GABRG3

Pathways associated with anti-GABRA3 antibody

Products by Pathway	Pathway Diagram
GABA A Receptor Activation Pathway antibodies	GABA A Receptor Activation Pathway Diagram
GABA Receptor Activation Pathway antibodies	GABA Receptor Activation Pathway Diagram
GABAergic Synapse Pathway antibodies	GABAergic Synapse Pathway Diagram
GABAergic Synapse Pathway antibodies	GABAergic Synapse Pathway Diagram
Ion Channel Transport Pathway antibodies	Ion Channel Transport Pathway Diagram
Ligand-gated Ion Channel Transport Pathway antibodies	Ligand-gated Ion Channel Transport Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Morphine Addiction Pathway antibodies	Morphine Addiction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram
Neuroactive Ligand-receptor Interaction Pathway antibodies	Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-GABRA3 antibody

Disease Name	Pubmed Publications
Nervous System Diseases Antibodies	>23 publications with GABRA3 and Nervous System Diseases
Anxiety Disorders Antibodies	>6 publications with GABRA3 and Anxiety Disorders
Disease Models, Animal Antibodies	>5 publications with GABRA3 and Disease Models, Animal
Depressive Disorder Antibodies	>4 publications with GABRA3 and Depressive Disorder
Seizures Antibodies	>2 publications with GABRA3 and Seizures
Lung Neoplasms Antibodies	>2 publications with GABRA3 and Lung Neoplasms
Depressive Disorder, Major Antibodies	>2 publications with GABRA3 and Depressive Disorder, Major
Poisoning Antibodies	>1 publications with GABRA3 and Poisoning
Alcoholism Antibodies	>1 publications with GABRA3 and Alcoholism
Liver Diseases Antibodies	>1 publications with GABRA3 and Liver Diseases

Organs/Tissues associated with anti-GABRA3 antibody

Organ/Tissue Name	Pubmed Publications
Brain Antibodies	>36 publications with GABRA3 and Brain
Testis Antibodies	>1 publications with GABRA3 and Testis