Rabbit Anti-MAP3K9 Polyclonal Antibody – Cat# MBS246952

Anti-MAP3K9 antibody IHC of human colon cancer. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

MAP3K9 Antibody – Rabbit Polyclonal

Name: MAP3K9 Antibody; Polyclonal; Rabbit; MyBioSource
Brand: MyBioSource
SKU: MBS246952
Price: 650 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS246952

MLK1 is a MLK(MAP3K) type protein kinase. In vitro studies suggest that it is a member of the neuronal apoptotic JNK/c-Jun pathway acting between Rac1/Cdc42 and MKK4 and -7 in death signaling. More details

$650 / 0.05 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MAP3K9 / MLK1, Polyclonal Antibody

Full Product Name

Rabbit Polyclonal to Human MAP3K9 / MLK1

Product Gene Name

anti-MAP3K9 antibody

Product Synonym Gene Name

MLK1

Product Synonym Names

Anti-MAP3K9 / MLK1 Antibody (Internal) IHC-plus; MAP3K9; MEKK9; MLK1; Mixed lineage kinase 1; PRKE1; Human MAP3K9; MLK1

Clonality

Polyclonal

Host

Rabbit

Species Reactivity

Gibbon, Gorilla, Hamster, Human, Mouse, Pig, Rabbit
Predicted Reactivity: Monkey, Bat, Bovine, Dog (at least 90% immunogen sequence identity)

Form/Format

PBS, 0.1% sodium azide.

Purity/Purification

Immunoaffinity Purified

Concentration

1 mg/ml (lot specific)

Specificity

Human MAP3K9. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Preparation and Storage

Long term: -70 degree C; Short term: +4 degree C

Molecular Weight

123,373 Da

OMIM

600136

3D Structure

ModBase 3D Structure for P80192

Target Species

Human

Immunogen Description

Synthetic 15 amino acid peptide from internal region of human MAP3K9. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Hamster, Rabbit, Pig (100%); Marmoset, Elephant, Panda, Bovine, Dog, Bat.

Immunogen Type

Synthetic peptide

Immunogen

MAP3K9 / MLK1 antibody was raised against synthetic 15 amino acid peptide from internal region of human MAP3K9. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Mouse, Hamster, Rabbit, Pig (100%); Marmoset, Elephant, Panda, Bovine, Dog, Bat, Opossum (93%); Horse, Turkey, Chicken (87%).

Antigen Modification

Internal

Product Categories/Family for anti-MAP3K9 antibody

Family: Protein Kinase; Subfamily: MLK (MAP3K)

Applications Tested/Suitable for anti-MAP3K9 antibody

Immunohistochemistry (IHC - Paraffin)

Application Notes for anti-MAP3K9 antibody

IHC-P (4 ug/ml)

Other Notes

Small volumes of anti-MAP3K9 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MAP3K9 purchase

MBS246952 is an antibody targeting MAP3K9. Also known as Rabbit Polyclonal to Human MAP3K9 / MLK1. Reactive in Gibbon, Gorilla, Hamster, Human, Mouse, Pig, Rabbit
Predicted Reactivity: Monkey, Bat, Bovine, Dog (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for MAP3K9. It may not necessarily be applicable to this product.

NCBI GI #

545746337

NCBI GeneID

4293

NCBI Accession #

NP_001271159.1

UniProt Primary Accession #

P80192

UniProt Secondary Accession #

Q0D2G7; Q6EH31; Q9H2N5; A3KN85

UniProt Related Accession #

P80192

GenBank Nucleotide #

NM_001284230.1

NCBI Official Full Name

mitogen-activated protein kinase kinase kinase 9 isoform 2

NCBI Official Synonym Full Names

mitogen-activated protein kinase kinase kinase 9

NCBI Official Symbol

MAP3K9

NCBI Official Synonym Symbols

MLK1; MEKK9; PRKE1

UniProt Protein Name

Mitogen-activated protein kinase kinase kinase 9

UniProt Synonym Protein Names

Mixed lineage kinase 1

Protein Family

Mitogen-activated protein kinase kinase kinase

UniProt Gene Name

MAP3K9

UniProt Synonym Gene Names

MLK1; PRKE1

UniProt Entry Name

M3K9_HUMAN

NCBI Protein Information

mitogen-activated protein kinase kinase kinase 9; mixed lineage kinase 1 (tyr and ser/thr specificity)

UniProt Comments for MAP3K9

MLK1: a TKL kinase of the MLK family. A dual leucine zipper kinase. Expressed in neuronal cells and may act between Rac1/Cdc42 and MKK4 and -7 in death signaling.

Protein type: Protein kinase, Ser/Thr (non-receptor); Kinase, protein; EC 2.7.11.25; Protein kinase, TKL; TKL group; MLK family; MLK subfamily

Chromosomal Location of Human Ortholog: 14q24.2

Molecular Function: MAP kinase kinase activity; protein serine/threonine kinase activity; protein binding; JUN kinase kinase kinase activity; protein homodimerization activity; protein-tyrosine kinase activity; ATP binding

Biological Process: peptidyl-tyrosine phosphorylation; regulation of transcription, DNA-dependent; transcription, DNA-dependent; positive regulation of apoptosis; apoptosis; protein amino acid autophosphorylation; protein amino acid phosphorylation; activation of JNK activity; activation of JNKK activity

Research Articles on MAP3K9

1. identified three kinases with gain-of-function mutations in lung cancer, namely FGFR4, MAP3K9, and PAK5. Mutations in these kinases are activating toward the ERK pathway, and targeted depletion of the mutated kinases inhibits proliferation

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-MAP3K9 antibody

Products by Pathway	Pathway Diagram
Insulin Signaling Pathway antibodies	Insulin Signaling Pathway Diagram
MAPK (JNK) Signaling Pathway antibodies	MAPK (JNK) Signaling Pathway Diagram
MAPK (JNK) Signaling Pathway antibodies	MAPK (JNK) Signaling Pathway Diagram
MAPK (p38) Signaling Pathway antibodies	MAPK (p38) Signaling Pathway Diagram
MAPK (p38) Signaling Pathway antibodies	MAPK (p38) Signaling Pathway Diagram
P38 MAPK Signaling Pathway antibodies	P38 MAPK Signaling Pathway Diagram

Diseases associated with anti-MAP3K9 antibody

Disease Name	Pubmed Publications
Inflammation Antibodies	>4 publications with MAP3K9 and Inflammation
Colonic Neoplasms Antibodies	>3 publications with MAP3K9 and Colonic Neoplasms
Syndrome Antibodies	>1 publications with MAP3K9 and Syndrome
Central Nervous System Diseases Antibodies	>1 publications with MAP3K9 and Central Nervous System Diseases
Lung Neoplasms Antibodies	>1 publications with MAP3K9 and Lung Neoplasms
Necrosis Antibodies	>1 publications with MAP3K9 and Necrosis
Fibrosis Antibodies	>1 publications with MAP3K9 and Fibrosis
Melanoma Antibodies	>1 publications with MAP3K9 and Melanoma

Organs/Tissues associated with anti-MAP3K9 antibody

Organ/Tissue Name	Pubmed Publications
Kidney Antibodies	>2 publications with MAP3K9 and Kidney
Testis Antibodies	>2 publications with MAP3K9 and Testis
Brain Antibodies	>2 publications with MAP3K9 and Brain
Eye Antibodies	>1 publications with MAP3K9 and Eye