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CD27L Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247002

CD70, also known as CD27L, is the ligand for CD27. It was first detected on the surface of Reed-Sternberg cells. CD70 is a type II transmembrane protein with an extracellular C-terminal domain. It is homologous to the ligands for the tissue necrosis factor… More details

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Product Overview

Product Name
CD27L / CD70, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human CD27L / CD70
Product Gene Name
Product Synonym Gene Name
CD70
Product Synonym Names
Anti-CD27L / CD70 Antibody (Internal) IHC-plus; CD70; CD27LG; Ki-24 antigen; Surface antigen CD70; CD27 ligand; CD27-L; CD70 antigen; CD70 molecule; TNFSF7; Human CD27L; CD70
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human, Monkey, Orangutan
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
0.4 mg/ml (lot specific)
Specificity
Human CD70. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
23,438 Da
OMIM
602840
3D Structure
ModBase 3D Structure for P32970
Target Species
Human
Immunogen Description
Synthetic 18 amino acid peptide from internal region of human CD70. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey (100%); Bovine, Rabbit (83%).
Immunogen Type
Synthetic peptide
Immunogen
CD27L / CD70 antibody was raised against synthetic 18 amino acid peptide from internal region of human CD70. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Gibbon, Monkey (100%); Bovine, Rabbit (83%).
Antigen Modification
Internal

Product Categories/Family for anti-CD27L antibody

Applications Tested/Suitable for anti-CD27L antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-CD27L antibody
IHC-P (15 ug/ml)

Immunohistochemistry (IHC) of anti-CD27L antibody

Anti-CD70 antibody IHC of human tonsil. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-CD27L Polyclonal Antibody – Cat# MBS247002

Immunohistochemistry (IHC) of anti-CD27L antibody

Anti-CD70 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-CD27L Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247002

Other Notes

Small volumes of anti-CD27L antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CD27L purchase

MBS247002 is an antibody targeting CD27L. Also known as Rabbit Polyclonal to Human CD27L / CD70. Reactive in Gibbon, Gorilla, Human, Monkey, Orangutan. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CD27L. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
CD70 antigen
NCBI Official Synonym Full Names
CD70 molecule
NCBI Official Symbol
CD70
NCBI Official Synonym Symbols
CD27L; CD27LG; TNFSF7
UniProt Protein Name
CD70 antigen
UniProt Synonym Protein Names
CD27 ligand; CD27-L; Tumor necrosis factor ligand superfamily member 7; CD_antigen: CD70
UniProt Gene Name
CD70
UniProt Synonym Gene Names
CD27L; CD27LG; TNFSF7; CD27-L
UniProt Entry Name
CD70_HUMAN
NCBI Protein Information
CD70 antigen; CD27-L; CD27 ligand; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand superfamily member 7; tumor necrosis factor (ligand) superfamily, member 7

NCBI Summary for CD27L

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]
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UniProt Comments for CD27L

CD70: Cytokine that binds to CD27. Plays a role in T-cell activation. Induces the proliferation of costimulated T-cells and enhances the generation of cytolytic T-cells. Belongs to the tumor necrosis factor family.

Protein type: Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13

Cellular Component: extracellular space; integral to plasma membrane; plasma membrane

Molecular Function: protein binding; protease binding; cytokine activity; tumor necrosis factor receptor binding; receptor binding

Biological Process: cell proliferation; cell-cell signaling; immune response; signal transduction
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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