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LINGO1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247006

Also known as LRRN6A (leucine-rich repeat neuronal 6A), LINGO1 is a newly discovered gene that is expressed primarily in the central nervous system during early embro development, and may be an essential protein in the development of the nervous system. More details

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Product Overview

Online Datasheet in PDF
Product Name
LINGO1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human LINGO1
Product Gene Name
anti-LINGO1 antibody
Product Synonym Names
Anti-LINGO1 Antibody (Internal) IHC-plus; LINGO1; LERN1; LRRN6A; UNQ201; Human LINGO1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Bovine, Dog, Gorilla, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat, Zebrafish
Predicted Reactivity: Bat, Chicken (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human LINGO1. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.
Molecular Weight
69,146 Da
OMIM
609791
3D Structure
ModBase 3D Structure for Q96FE5
Target Species
Human
Immunogen Description
Synthetic 17 amino acid peptide from internal region of human LINGO1.
Immunogen Type
Synthetic peptide
Immunogen
LINGO1 antibody was raised against synthetic 17 amino acid peptide from internal region of human LINGO1. Percent identity with other species by BLAST analysis: Human, Gorilla, Orangutan, Monkey, Marmoset, Mouse, Rat, Elephant, Panda, Bovine, Dog, Horse, Rabbit, Pig, Stickleback, Zebrafish (100%); Bat, Opossum, Turkey, Chicken, Pufferfish (94%); Xenopus (82%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-LINGO1 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-LINGO1 antibody
IHC-P (20 ug/ml)

Immunohistochemistry (IHC) of anti-LINGO1 antibody

Anti-LINGO1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-LINGO1 Polyclonal Antibody – Cat# MBS247006

Other Notes

Small volumes of anti-LINGO1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LINGO1 purchase

MBS247006 is an antibody targeting LINGO1. Also known as Rabbit Polyclonal to Human LINGO1. Reactive in Bovine, Dog, Gorilla, Horse, Human, Monkey, Mouse, Orangutan, Pig, Rabbit, Rat, Zebrafish
Predicted Reactivity: Bat, Chicken (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for LINGO1. It may not necessarily be applicable to this product.

NCBI GI #
50263044
NCBI GeneID
84894
NCBI Accession #
NP_116197.4
UniProt Primary Accession #
Q96FE5
UniProt Secondary Accession #
Q6NUK3; Q6UXM3; Q6VVG0; Q6VVG1; Q6VVG2; Q8N3K5; Q96K52; D3DW80
UniProt Related Accession #
Q96FE5
GenBank Nucleotide #
NM_032808.6
NCBI Official Full Name
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform a
NCBI Official Synonym Full Names
leucine rich repeat and Ig domain containing 1
NCBI Official Symbol
LINGO1
NCBI Official Synonym Symbols
LERN1; LRRN6A; UNQ201
UniProt Protein Name
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1
UniProt Synonym Protein Names
Leucine-rich repeat and immunoglobulin domain-containing protein 1; Leucine-rich repeat neuronal protein 1; Leucine-rich repeat neuronal protein 6A
Protein Family
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein
UniProt Gene Name
LINGO1
UniProt Synonym Gene Names
LERN1; LRRN6A
UniProt Entry Name
LIGO1_HUMAN
NCBI Protein Information
leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1; leucine rich repeat neuronal 6A; leucine-rich repeat neuronal protein 1; leucine-rich repeat and immunoglobulin domain-containing protein 1

UniProt Comments for LINGO1

LINGO1: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination. Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral

Chromosomal Location of Human Ortholog: 15q24.3

Cellular Component: plasma membrane; integral to membrane

Molecular Function: epidermal growth factor receptor binding

Biological Process: negative regulation of oligodendrocyte differentiation; nerve growth factor receptor signaling pathway; protein kinase B signaling cascade; negative regulation of axonogenesis; regulation of axonogenesis; neurite development; central nervous system neuron development
Show more

Research Articles on LINGO1

1. This review found that several gene variants in the LINGO1 gene may increase the risk of essential tremor.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-LINGO1 antibody

 Reference Product  PubMed Publications
 RTN4R antibody  >11 publications with LINGO1 and RTN4R
 TNFRSF19 antibody  >9 publications with LINGO1 and TNFRSF19
 OMG antibody  >3 publications with LINGO1 and OMG
 EGFR antibody  >2 publications with LINGO1 and EGFR
 HS1BP3 antibody  >1 publications with LINGO1 and HS1BP3
 LINGO3 antibody  >1 publications with LINGO1 and LINGO3
 DRD3 antibody  >1 publications with LINGO1 and DRD3
 NGFR antibody  >1 publications with LINGO1 and NGFR

Pathways associated with anti-LINGO1 antibody

 Products by Pathway  Pathway Diagram
 Axonal Growth Inhibition (RHOA Activation) Pathway antibodies  Axonal Growth Inhibition (RHOA Activation) Pathway Diagram
 BDNF Signaling Pathway antibodies  BDNF Signaling Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signalling By NGF Pathway antibodies  Signalling By NGF Pathway Diagram
 P75 NTR Receptor-mediated Signalling Pathway antibodies  P75 NTR Receptor-mediated Signalling Pathway Diagram
 P75NTR Regulates Axonogenesis Pathway antibodies  P75NTR Regulates Axonogenesis Pathway Diagram

Diseases associated with anti-LINGO1 antibody

 Disease Name  Pubmed Publications
 Essential Tremor Antibodies  >35 publications with LINGO1 and Essential Tremor
 Disease Models, Animal Antibodies  >14 publications with LINGO1 and Disease Models, Animal
 Necrosis Antibodies  >9 publications with LINGO1 and Necrosis
 Inflammation Antibodies  >4 publications with LINGO1 and Inflammation
 Abnormalities, Multiple Antibodies  >1 publications with LINGO1 and Abnormalities, Multiple
 Neoplasms, Experimental Antibodies  >1 publications with LINGO1 and Neoplasms, Experimental
 Cognition Disorders Antibodies  >1 publications with LINGO1 and Cognition Disorders
 Learning Disorders Antibodies  >1 publications with LINGO1 and Learning Disorders
 Memory Disorders Antibodies  >1 publications with LINGO1 and Memory Disorders

Organs/Tissues associated with anti-LINGO1 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >34 publications with LINGO1 and Brain
 Ganglia Antibodies  >10 publications with LINGO1 and Ganglia
 Embryonic Tissue Antibodies  >7 publications with LINGO1 and Embryonic Tissue
 Eye Antibodies  >6 publications with LINGO1 and Eye
 Ovary Antibodies  >1 publications with LINGO1 and Ovary
 Uncharacterized Tissue Antibodies  >1 publications with LINGO1 and Uncharacterized Tissue
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