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HEP Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247028

EPHB6 belongs to the ephrin receptor kinase family. EPHB6 does not have intrinsic tyrosine kinase activity because six invariant amino acids were have been substituted. Despite its lack of kinase activity, ligand binding results in trans-phosphorylation of… More details

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Product Overview

Product Name
HEP / EPHB6, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human HEP / EPHB6
Product Gene Name
anti-HEP antibody
Product Synonym Gene Name
EPHB6
Product Synonym Names
Anti-HEP / EPHB6 Antibody (aa831-843) IHC-plus; EPHB6; Cekl; EPH receptor B6; Ephrin type-B receptor 6; HEP; MEP; Human HEP; EPHB6
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Chimpanzee, Dog, Gorilla, Human
Predicted Reactivity: Monkey, Horse, Pig, Rabbit (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human EPHB6.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
57,498 Da
OMIM
602757
3D Structure
ModBase 3D Structure for O15197
Target Species
Human
Immunogen Description
Synthetic peptide C-EVIAHGKHTTSSD from positions 831-843 of human EPHB6 (NP_004436.2). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Dog (100%); Monkey, Marmoset, Panda, Horse, Rabbit, Pig (92%); Mouse, Rat (85%).
Immunogen Type
Synthetic peptide
Immunogen
HEP / EPHB6 antibody was raised against synthetic peptide C-EVIAHGKHTTSSD from positions 831-843 of human EPHB6 (NP_004436.2). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Gibbon, Dog (100%); Monkey, Marmoset, Panda, Horse, Rabbit, Pig (92%); Mouse, Rat (85%).
Antigen Modification
aa831-843

Product Categories/Family for anti-HEP antibody

Family: Protein Kinase; Subfamily: Ephrin Receptor
Applications Tested/Suitable for anti-HEP antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-HEP antibody
IHC-P (3.75 - 7.5 ug/ml)

Immunohistochemistry (IHC) of anti-HEP antibody

Anti-EPHB6 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-HEP Polyclonal Antibody – Cat# MBS247028

Immunohistochemistry (IHC) of anti-HEP antibody

Anti-EPHB6 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-HEP Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247028

Other Notes

Small volumes of anti-HEP antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HEP purchase

MBS247028 is an antibody targeting HEP. Also known as Goat Polyclonal to Human HEP / EPHB6. Reactive in Gibbon, Chimpanzee, Dog, Gorilla, Human
Predicted Reactivity: Monkey, Horse, Pig, Rabbit (at least 90% immunogen sequence identity). Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for HEP. It may not necessarily be applicable to this product.

NCBI GI #
194097332
NCBI GeneID
2051
NCBI Accession #
NP_004436.2
UniProt Primary Accession #
O15197
UniProt Secondary Accession #
Q2TB23; Q2TB24; A4D2I7; A8CDT5; D3DXD3
UniProt Related Accession #
O15197
GenBank Nucleotide #
NM_004445.3
NCBI Official Full Name
ephrin type-B receptor 6
NCBI Official Synonym Full Names
EPH receptor B6
NCBI Official Symbol
EPHB6
NCBI Official Synonym Symbols
HEP
UniProt Protein Name
Ephrin type-B receptor 6
UniProt Synonym Protein Names
HEP; Tyrosine-protein kinase-defective receptor EPH-6
Protein Family
Dual specificity mitogen-activated protein kinase kinase hemipterous
UniProt Gene Name
EPHB6
UniProt Entry Name
EPHB6_HUMAN
NCBI Protein Information
ephrin type-B receptor 6; tyrosine-protein kinase-defective receptor EPH-6; human kinase-defective Eph-family receptor protein

NCBI Summary for HEP

This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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UniProt Comments for HEP

EphB6: Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); EC 2.7.10.1; Protein kinase, TK; Kinase, protein; TK group; Eph family

Chromosomal Location of Human Ortholog: 7q33-q35

Cellular Component: integral to plasma membrane; plasma membrane; extracellular region; cytosol

Molecular Function: ephrin receptor activity; receptor activity; ATP binding

Biological Process: axon guidance; ephrin receptor signaling pathway; protein amino acid phosphorylation
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Research Articles on HEP

1. Data found significant correlations between ephA2, ephA4, ephA7, ephB4, and ephB6 and overall and/or recurrence-free survival in large microarray datasets.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-HEP antibody

 Reference Product  PubMed Publications
 EFNB3 antibody  >9 publications with HEP and EFNB3
 EFNB2 antibody  >8 publications with HEP and EFNB2
 CBL antibody  >3 publications with HEP and CBL
 EFNB1 antibody  >3 publications with HEP and EFNB1
 PDGFRB antibody  >2 publications with HEP and PDGFRB
 EFNA1 antibody  >2 publications with HEP and EFNA1
 EFNA5 antibody  >1 publications with HEP and EFNA5
 EFNA3 antibody  >1 publications with HEP and EFNA3

Pathways associated with anti-HEP antibody

 Products by Pathway  Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Axon Guidance Pathway antibodies  Axon Guidance Pathway Diagram
 Developmental Biology Pathway antibodies  Developmental Biology Pathway Diagram
 EPH-Ephrin Signaling Pathway antibodies  EPH-Ephrin Signaling Pathway Diagram
 EPH-ephrin Mediated Repulsion Of Cells Pathway antibodies  EPH-ephrin Mediated Repulsion Of Cells Pathway Diagram
 EPHB-mediated Forward Signaling Pathway antibodies  EPHB-mediated Forward Signaling Pathway Diagram
 Ephrin Signaling Pathway antibodies  Ephrin Signaling Pathway Diagram

Diseases associated with anti-HEP antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >11 publications with HEP and Breast Neoplasms
 Lung Neoplasms Antibodies  >11 publications with HEP and Lung Neoplasms
 Nervous System Diseases Antibodies  >6 publications with HEP and Nervous System Diseases
 Brain Diseases Antibodies  >5 publications with HEP and Brain Diseases
 Neoplasms, Experimental Antibodies  >4 publications with HEP and Neoplasms, Experimental
 Liver Neoplasms Antibodies  >3 publications with HEP and Liver Neoplasms
 Disease Models, Animal Antibodies  >2 publications with HEP and Disease Models, Animal
 Pancreatic Neoplasms Antibodies  >2 publications with HEP and Pancreatic Neoplasms
 Immune System Diseases Antibodies  >2 publications with HEP and Immune System Diseases
 Cardiovascular Diseases Antibodies  >2 publications with HEP and Cardiovascular Diseases

Organs/Tissues associated with anti-HEP antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >18 publications with HEP and Blood
 Lung Antibodies  >12 publications with HEP and Lung
 Brain Antibodies  >10 publications with HEP and Brain
 Thymus Antibodies  >7 publications with HEP and Thymus
 Bone Antibodies  >6 publications with HEP and Bone
 Liver Antibodies  >5 publications with HEP and Liver
 Embryonic Tissue Antibodies  >5 publications with HEP and Embryonic Tissue
 Kidney Antibodies  >4 publications with HEP and Kidney
 Lymph Node Antibodies  >3 publications with HEP and Lymph Node
 Muscle Antibodies  >2 publications with HEP and Muscle
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