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NOD8 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247053

MBS247053 is an antibody targeting NOD8. Also known as Rabbit Polyclonal to Human NOD8 / NLRP10. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
NOD8 / NLRP10, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human NOD8 / NLRP10
Product Gene Name
Product Synonym Gene Name
NLRP10
Product Synonym Names
Anti-NOD8 / NLRP10 Antibody (N-Terminus) IHC-plus; NLRP10; CLR11.1; PYNOD; NALP10; NOD8; PAN5; Human NOD8; NLRP10
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human NLRP10
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
75,032 Da
OMIM
609662
3D Structure
ModBase 3D Structure for Q86W26
Target Species
Human
Immunogen Description
A 14 amino acid peptide near the amino terminus of human NALP10.
Immunogen Type
Synthetic peptide
Immunogen
NOD8 / NLRP10 antibody was raised against a 14 amino acid peptide near the amino terminus of human NALP10.
Antigen Modification
N-Terminus
Applications Tested/Suitable for anti-NOD8 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-NOD8 antibody
ELISA, IHC-P (5 ug/ml), WB (1 - 2 ug/ml)
Usage: NALP10 antibody can be used for detection of NALP10 by Western blot at 1-2 ug/ml.

Immunohistochemistry (IHC) of anti-NOD8 antibody

Anti-NLRP10 antibody IHC of human thymus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-NOD8 Polyclonal Antibody – Cat# MBS247053

Immunohistochemistry (IHC) of anti-NOD8 antibody

Anti-NLRP10 antibody IHC of human placenta. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-NOD8 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247053

Immunofluorescence (IF) of anti-NOD8 antibody

Immunofluorescence of NALP10 in human brain tissue with NALP10 antibody at 20 ug/ml.
Rabbit Anti-NOD8 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS247053

Western Blot (WB) of anti-NOD8 antibody

Western blot analysis of NALP10 in human brain tissue lysate with NALP10 antibody at 1 ug/ml.
Rabbit Anti-NOD8 Polyclonal Antibody, Western Blot (WB) – Cat# MBS247053

Other Notes

Small volumes of anti-NOD8 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for NOD8. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
NACHT, LRR and PYD domains-containing protein 10
NCBI Official Synonym Full Names
NLR family, pyrin domain containing 10
NCBI Official Symbol
NLRP10
NCBI Official Synonym Symbols
NOD8; PAN5; PYNOD; NALP10; CLR11.1
UniProt Protein Name
NACHT, LRR and PYD domains-containing protein 10
UniProt Synonym Protein Names
Nucleotide-binding oligomerization domain protein 8
UniProt Gene Name
NLRP10
UniProt Synonym Gene Names
NALP10; NOD8; PYNOD
UniProt Entry Name
NAL10_HUMAN
NCBI Protein Information
NACHT, LRR and PYD domains-containing protein 10; NACHT, leucine rich repeat and PYD containing 10; nucleotide-binding oligomerization domain protein 8; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 10

NCBI Summary for NOD8

Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). The protein encoded by this gene belongs to the NALP protein family despite lacking the LRR region. This protein likely plays a regulatory role in the innate immune system. The protein belongs to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. Other experiments indicate that this gene acts as a multifunctional negative regulator of inflammation and apoptosis. [provided by RefSeq, Jul 2008]
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UniProt Comments for NOD8

NALP10: Inhibits CASP1/caspase-1-dependent IL1B secretion and PYCARD-mediated apoptosis, but not that induced by FAS or BID. Belongs to the NLRP family.

Protein type: Unknown function

Chromosomal Location of Human Ortholog: 11p15.4

Cellular Component: extrinsic to plasma membrane; cytoplasm

Molecular Function: ATP binding

Biological Process: positive regulation of T-helper 1 type immune response; innate immune response; defense response to Gram-negative bacterium; defense response to fungus
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-NOD8 antibody

Pathways associated with anti-NOD8 antibody

 Products by Pathway  Pathway Diagram
 NOD Pathway antibodies  NOD Pathway Diagram

Diseases associated with anti-NOD8 antibody

 Disease Name  Pubmed Publications
 Necrosis Antibodies  >3 publications with NOD8 and Necrosis
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