KCNN4 Antibody – Rabbit Polyclonal

The protein encoded by this gene is part of a potentially heterotetrameric voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization, which promotes calcium influx. The encoded protein may be part of the predominant calcium-activated potassium channel in T-lymphocytes. This gene is similar to other KCNN family potassium channel genes, but it differs enough to possibly be considered as part of a new subfamily. [provided by RefSeq, Jul 2008]

KCNN4: Forms a voltage-independent potassium channel that is activated by intracellular calcium. Activation is followed by membrane hyperpolarization which promotes calcium influx. Required for maximal calcium influx and proliferation during the reactivation of naive T-cells. The channel is blocked by clotrimazole and charybdotoxin but is insensitive to apamin. Belongs to the potassium channel KCNN family. KCa3.1/KCNN4 subfamily.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Channel, potassium

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: voltage-gated potassium channel complex; cell soma; basolateral plasma membrane; apical plasma membrane; plasma membrane; lipid raft

Molecular Function: calmodulin binding; calcium-activated potassium channel activity; protein binding; Intermediate conductance calcium-activated potassium channel activity; small conductance calcium-activated potassium channel activity; protein phosphatase binding

Biological Process: phospholipid translocation; synaptic transmission; positive regulation of T cell receptor signaling pathway; positive regulation of protein secretion; immune system process; calcium ion transport; defense response; cell volume homeostasis; saliva secretion; stabilization of membrane potential; potassium ion transport