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DUSP22 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247105

MKPX, also known as JSP-1 for Jnk Stimulatory Phosphatase-1, belongs to the LMW-DSP subfamily of phosphatases. MKPX has been shown to have the capacity to activate the c-Jun N-terminal kinase (Jnk) signaling pathway. The activation of Jnk has been implicated… More details

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Product Overview

Online Datasheet in PDF
Product Name
DUSP22 / JSP 1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human DUSP22 / JSP 1
Product Gene Name
anti-DUSP22 antibody
Product Synonym Gene Name
JSP 1
Product Synonym Names
Anti-DUSP22 / JSP 1 Antibody (Internal) IHC-plus; DUSP22; JSP 1; JKAP; JNK-stimulating phosphatase 1; LMW-DSP2; Map kinase phosphatase x; MKPX; VHX; JNK-stimulatory phosphatase-1; JSP-1; JSP1; LMWDSP2; MKP-X; Human DUSP22; JSP 1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human
Predicted Reactivity: Monkey, Bat, Dog, Hamster, Horse, Rabbit (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human DUSP22. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except ATAD3B (45%), TAF2 (35%).
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
23,268 Da
3D Structure
ModBase 3D Structure for Q9NRW4
Target Species
Human
Immunogen Description
Synthetic 20 amino acid peptide from internal region of human DUSP22. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Elephant (100%); Monkey, Marmoset, Horse (95%); Hamster, Dog, Bat, Rabbit (90%).
Immunogen Type
Synthetic peptide
Immunogen
DUSP22 / JSP 1 antibody was raised against synthetic 20 amino acid peptide from internal region of human DUSP22. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Elephant (100%); Monkey, Marmoset, Horse (95%); Hamster, Dog, Bat, Rabbit (90%); Mouse, Opossum, Platypus (85%); Rat, Bovine (80%).
Antigen Modification
Internal

Product Categories/Family for anti-DUSP22 antibody

Family: Protein Phosphatase; Subfamily: LMW-DSP
Applications Tested/Suitable for anti-DUSP22 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-DUSP22 antibody
IHC-P (1 - 7 ug/ml)

Immunohistochemistry (IHC) of anti-DUSP22 antibody

Anti-DUSP22 antibody IHC of human acinar epithelial cells. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-DUSP22 Polyclonal Antibody – Cat# MBS247105

Immunohistochemistry (IHC) of anti-DUSP22 antibody

Anti-DUSP22 / JSP 1 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-DUSP22 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247105

Other Notes

Small volumes of anti-DUSP22 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DUSP22 purchase

MBS247105 is an antibody targeting DUSP22. Also known as Rabbit Polyclonal to Human DUSP22 / JSP 1. Reactive in Gibbon, Gorilla, Human
Predicted Reactivity: Monkey, Bat, Dog, Hamster, Horse, Rabbit (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for DUSP22. It may not necessarily be applicable to this product.

NCBI GI #
9910432
NCBI GeneID
56940
NCBI Accession #
NP_064570.1
UniProt Primary Accession #
Q9NRW4
UniProt Secondary Accession #
Q59GW2; Q5VWR2; Q96AR1; B4DK56
UniProt Related Accession #
Q9NRW4
GenBank Nucleotide #
NM_020185.4
NCBI Official Full Name
dual specificity protein phosphatase 22 isoform b
NCBI Official Synonym Full Names
dual specificity phosphatase 22
NCBI Official Symbol
DUSP22
NCBI Official Synonym Symbols
VHX; JKAP; JSP1; MKPX; JSP-1; MKP-x; LMWDSP2; LMW-DSP2
UniProt Protein Name
Dual specificity protein phosphatase 22
UniProt Synonym Protein Names
JNK-stimulatory phosphatase-1; JSP-1; Low molecular weight dual specificity phosphatase 2; LMW-DSP2; Mitogen-activated protein kinase phosphatase x; MAP kinase phosphatase x; MKP-x
Protein Family
Dual specificity protein phosphatase
UniProt Gene Name
DUSP22
UniProt Synonym Gene Names
JSP1; LMWDSP2; MKPX; JSP-1; LMW-DSP2; MAP kinase phosphatase x; MKP-x
UniProt Entry Name
DUS22_HUMAN
NCBI Protein Information
dual specificity protein phosphatase 22; MAP kinase phosphatase x; JNK-stimulating phosphatase 1; JNK-stimulatory phosphatase-1; mitogen-activated protein kinase phosphatase x; low molecular weight dual specificity phosphatase 2; homolog of mouse dual specificity phosphatase LMW-DSP2

UniProt Comments for DUSP22

DUSP22: Activates the Jnk signaling pathway. Dephosphorylates and deactivates p38 and stress-activated protein kinase/c-Jun N- terminal kinase (SAPK/JNK). Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Apoptosis; Protein phosphatase, dual-specificity

Chromosomal Location of Human Ortholog: 6p25.3

Cellular Component: cytoplasm; nucleus

Molecular Function: protein tyrosine/serine/threonine phosphatase activity; protein tyrosine phosphatase activity

Biological Process: cell proliferation; apoptosis; multicellular organismal development; transforming growth factor beta receptor signaling pathway; positive regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; protein amino acid dephosphorylation; regulation of cell proliferation; inactivation of MAPK activity
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Research Articles on DUSP22

1. study identified presence of promoter hypermethylation of the DUSP22 gene in Alzheimer's disease(AD); DUSP22 is a likely candidate gene for involvement in the pathogenesis of AD since it inhibits PKA activity and thereby determines TAU phosphorylation status and CREB signaling

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DUSP22 antibody

 Reference Product  PubMed Publications
 STAT3 antibody  >1 publications with DUSP22 and STAT3
 MAPK8 antibody  >1 publications with DUSP22 and MAPK8

Diseases associated with anti-DUSP22 antibody

 Disease Name  Pubmed Publications
 Lymphoma Antibodies  >11 publications with DUSP22 and Lymphoma
 Carcinoma Antibodies  >3 publications with DUSP22 and Carcinoma
 Breast Neoplasms Antibodies  >2 publications with DUSP22 and Breast Neoplasms
 Bacterial Infections Antibodies  >1 publications with DUSP22 and Bacterial Infections
 Weight Loss Antibodies  >1 publications with DUSP22 and Weight Loss
 Adenocarcinoma Antibodies  >1 publications with DUSP22 and Adenocarcinoma
 Lung Neoplasms Antibodies  >1 publications with DUSP22 and Lung Neoplasms
 Inflammation Antibodies  >1 publications with DUSP22 and Inflammation
 Carcinoma, Hepatocellular Antibodies  >1 publications with DUSP22 and Carcinoma, Hepatocellular
 Liver Neoplasms Antibodies  >1 publications with DUSP22 and Liver Neoplasms

Organs/Tissues associated with anti-DUSP22 antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >11 publications with DUSP22 and Blood
 Skin Antibodies  >5 publications with DUSP22 and Skin
 Brain Antibodies  >3 publications with DUSP22 and Brain
 Liver Antibodies  >2 publications with DUSP22 and Liver
 Vascular Antibodies  >2 publications with DUSP22 and Vascular
 Testis Antibodies  >2 publications with DUSP22 and Testis
 Thymus Antibodies  >1 publications with DUSP22 and Thymus
 Thyroid Antibodies  >1 publications with DUSP22 and Thyroid
 Lymph Antibodies  >1 publications with DUSP22 and Lymph
 Lymph Node Antibodies  >1 publications with DUSP22 and Lymph Node
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