SSTR5 Antibody – Rabbit Polyclonal

Somatostatin and its related peptide cortistatin exert multiple biological actions on normal and tumoral tissue targets by interacting with somatostatin receptors (SSTRs). The protein encoded by this gene is one of the SSTRs, which is a multi-pass membrane protein and belongs to the G-protein coupled receptor 1 family. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase, and different regions of this receptor molecule are required for the activation of different signaling pathways. A mutation in this gene results in somatostatin analog resistance. Alternatively spliced transcript variants have been identified in this gene.[provided by RefSeq, Feb 2010]

SSTR5: Receptor for somatostatin 28 and to a lesser extent for somatostatin-14. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Cell cycle regulation

Chromosomal Location of Human Ortholog: 16p13.3

Cellular Component: neuron projection; integral to plasma membrane; plasma membrane

Molecular Function: neuropeptide binding; somatostatin receptor activity

Biological Process: positive regulation of cytokinesis; synaptic transmission; G-protein signaling, coupled to cyclic nucleotide second messenger; negative regulation of cell proliferation; G-protein coupled receptor protein signaling pathway; neuropeptide signaling pathway; glucose homeostasis; regulation of insulin secretion

Disease: Pituitary Adenoma, Growth Hormone-secreting