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RXFP2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247283

LGR8 is a member of the Relaxin Receptor subfamily. LGR8 has been shown to be important for testis descent. More details

$650 / 0.05 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
RXFP2 / LGR8, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human RXFP2 / LGR8
Product Gene Name
anti-RXFP2 antibody
Product Synonym Gene Name
LGR8
Product Synonym Names
Anti-RXFP2 / LGR8 Antibody (Extracellular Domain) IHC-plus; RXFP2; G-protein coupled receptor 106; GPR106; INSL3R; LGR8; GREAT; Relaxin receptor 2; LGR8.1; RXFPR2; Human RXFP2; LGR8
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gorilla, Human
Predicted Reactivity: Gibbon, Monkey, Bat, Horse (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human RXFP2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except RXFP1 (53%).
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
83,736 Da
OMIM
phenotype 606655
3D Structure
ModBase 3D Structure for Q8WXD0
Target Species
Human
Immunogen Description
Synthetic 17 amino acid peptide from 2nd extracellular domain of human RXFP2. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Marmoset, Elephant, Panda, Bat, Horse (94%); Monkey, Dog, Pig (88%).
Immunogen Type
Synthetic peptide
Immunogen
RXFP2 / LGR8 antibody was raised against synthetic 17 amino acid peptide from 2nd extracellular domain of human RXFP2. Percent identity with other species by BLAST analysis: Human, Gorilla (100%); Gibbon, Marmoset, Elephant, Panda, Bat, Horse (94%); Monkey, Dog, Pig (88%); Bovine, Rabbit, Platypus, Xenopus (82%).
Antigen Modification
Extracellular Domain

Product Categories/Family for anti-RXFP2 antibody

Family: GPCR; Subfamily: Relaxin
Applications Tested/Suitable for anti-RXFP2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-RXFP2 antibody
IHC-P (18 - 72 ug/ml)

Immunohistochemistry (IHC) of anti-RXFP2 antibody

Anti-RXFP2 / LGR8 antibody IHC of human Lung, Non-Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-RXFP2 Polyclonal Antibody – Cat# MBS247283

Immunohistochemistry (IHC) of anti-RXFP2 antibody

Anti-RXFP2 / LGR8 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-RXFP2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247283

Immunohistochemistry (IHC) of anti-RXFP2 antibody

Anti-RXFP2 antibody IHC of human uterus. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-RXFP2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247283

Other Notes

Small volumes of anti-RXFP2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RXFP2 purchase

MBS247283 is an antibody targeting RXFP2. Also known as Rabbit Polyclonal to Human RXFP2 / LGR8. Reactive in Gorilla, Human
Predicted Reactivity: Gibbon, Monkey, Bat, Horse (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for RXFP2. It may not necessarily be applicable to this product.

NCBI GI #
18677729
NCBI GeneID
122042
NCBI Accession #
NP_570718.1
UniProt Primary Accession #
Q8WXD0
UniProt Secondary Accession #
Q3KU23; B1ALE9
UniProt Related Accession #
Q8WXD0
GenBank Nucleotide #
NM_130806.3
NCBI Official Full Name
relaxin receptor 2 isoform 1
NCBI Official Synonym Full Names
relaxin/insulin-like family peptide receptor 2
NCBI Official Symbol
RXFP2
NCBI Official Synonym Symbols
LGR8; GREAT; GPR106; INSL3R; LGR8.1; RXFPR2
UniProt Protein Name
Relaxin receptor 2
UniProt Synonym Protein Names
G-protein coupled receptor 106; G-protein coupled receptor affecting testicular descent; Leucine-rich repeat-containing G-protein coupled receptor 8; Relaxin family peptide receptor 2
Protein Family
Relaxin receptor
UniProt Gene Name
RXFP2
UniProt Synonym Gene Names
GPR106; GREAT; LGR8
UniProt Entry Name
RXFP2_HUMAN
NCBI Protein Information
relaxin receptor 2; G-protein coupled receptor 106; relaxin family peptide receptor 2; G protein coupled receptor affecting testicular descent; G-protein coupled receptor affecting testicular descent; leucine-rich repeat-containing G protein-coupled receptor 8; leucine-rich repeat-containing G-protein coupled receptor 8

NCBI Summary for RXFP2

This gene encodes a member of the GPCR (G protein-coupled, 7-transmembrane receptor) family. Mutations in this gene are associated with cryptorchidism. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]

UniProt Comments for RXFP2

LGR8: the relaxin receptor is a G-protein coupled receptor (GPCR) that leads to the stimulation of adenylate cyclase and an increase of cAMP. May also be a receptor for Leydig insulin-like peptide (INSL3).

Protein type: GPCR, family 1; Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 13q13.1

Cellular Component: plasma membrane; integral to membrane

Molecular Function: peptide hormone binding; protein-hormone receptor activity

Biological Process: negative regulation of cell proliferation; male gonad development; positive regulation of cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; oocyte maturation; G-protein signaling, adenylate cyclase activating pathway; negative regulation of apoptosis

Disease: Cryptorchidism, Unilateral Or Bilateral
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Research Articles on RXFP2

1. Mapping key regions of the RXFP2 low-density lipoprotein class-A module that are involved in signal activation.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RXFP2 antibody

 Reference Product  PubMed Publications
 INSL3 antibody  >97 publications with RXFP2 and INSL3
 RXFP1 antibody  >73 publications with RXFP2 and RXFP1

Pathways associated with anti-RXFP2 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Myometrial Relaxation And Contraction Pathways antibodies  Myometrial Relaxation And Contraction Pathways Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-RXFP2 antibody

 Disease Name  Pubmed Publications
 Cryptorchidism Antibodies  >39 publications with RXFP2 and Cryptorchidism
 Fibrosis Antibodies  >7 publications with RXFP2 and Fibrosis
 Cardiovascular Diseases Antibodies  >3 publications with RXFP2 and Cardiovascular Diseases
 Pregnancy Complications Antibodies  >3 publications with RXFP2 and Pregnancy Complications
 Thyroid Neoplasms Antibodies  >2 publications with RXFP2 and Thyroid Neoplasms
 Prenatal Exposure Delayed Effects Antibodies  >2 publications with RXFP2 and Prenatal Exposure Delayed Effects
 Asthma Antibodies  >2 publications with RXFP2 and Asthma
 Carcinoma, Hepatocellular Antibodies  >1 publications with RXFP2 and Carcinoma, Hepatocellular
 Weight Loss Antibodies  >1 publications with RXFP2 and Weight Loss
 Hyperplasia Antibodies  >1 publications with RXFP2 and Hyperplasia
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