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CRHR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247322

CRHR2, a Corticotropin-Releasing Factor Receptor is a neuroregulator of the hypothalamic-pituitary-adrenocortical axis and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Mutations of… More details

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Product Overview

Online Datasheet in PDF
Product Name
CRHR2 / CRF2 Receptor, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human CRHR2 / CRF2 Receptor
Product Gene Name
anti-CRHR2 antibody
Product Synonym Names
Anti-CRHR2 / CRF2 Receptor Antibody (N-Terminus) IHC-plus; CRHR2; CRF-R-2; CRF-R2; CRF2R; Crh2 receptor; CRF2 receptor; beta isoform; CRFR2; CRFR-2; CRH-R-2; CRH2R; CRF-RB; CRF2; CRH-R2; HM-CRF; Human CRHR2; CRF2 Receptor
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Horse, Human, Monkey, Rat
Predicted Reactivity: Mouse, Bovine, Dog, Pig, Rabbit (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human CRHR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except CRHR1 (40%).
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
47,560 Da
OMIM
602034
3D Structure
ModBase 3D Structure for Q13324
Target Species
Human
Immunogen Description
Synthetic 20 amino acid peptide from N-terminal extracellular domain of human CRHR2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rat, Horse (100%); Mouse, Bovine, Rabbit (95%); Dog, Pig (90%).
Immunogen Type
Synthetic peptide
Immunogen
CRHR2 / CRF2 Receptor antibody was raised against synthetic 20 amino acid peptide from N-terminal extracellular domain of human CRHR2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rat, Horse (100%); Mouse, Bovine, Rabbit (95%); Dog, Pig (90%); Panda, Bat (85%).
Antigen Modification
N-Terminus

Product Categories/Family for anti-CRHR2 antibody

Family: GPCR; Subfamily: Corticotropin releasing factor
Applications Tested/Suitable for anti-CRHR2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-CRHR2 antibody
IHC-P (6 ug/ml)

Immunohistochemistry (IHC) of anti-CRHR2 antibody

Anti-CRHR2 / CRF2 Receptor antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-CRHR2 Polyclonal Antibody – Cat# MBS247322

Immunohistochemistry (IHC) of anti-CRHR2 antibody

Anti-CRHR2 antibody IHC of human brain, pituitary. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-CRHR2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247322

Immunohistochemistry (IHC) of anti-CRHR2 antibody

Anti-CRHR2 / CRF2 Receptor antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-CRHR2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247322

Immunohistochemistry (IHC) of anti-CRHR2 antibody

Anti-CRHR2 / CRF2 Receptor antibody IHC of human Skin, Melanoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-CRHR2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247322

Other Notes

Small volumes of anti-CRHR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CRHR2 purchase

MBS247322 is an antibody targeting CRHR2. Also known as Rabbit Polyclonal to Human CRHR2 / CRF2 Receptor. Reactive in Gibbon, Gorilla, Horse, Human, Monkey, Rat
Predicted Reactivity: Mouse, Bovine, Dog, Pig, Rabbit (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CRHR2. It may not necessarily be applicable to this product.

NCBI GI #
32307159
NCBI GeneID
1395
NCBI Accession #
NP_001874.2
UniProt Primary Accession #
Q13324
UniProt Secondary Accession #
O43461; Q4QRJ4; Q99431; B2R967; B3SXS6; B3SXS7; B3SXS8; B3SXT0; F8WA81
UniProt Related Accession #
Q13324
GenBank Nucleotide #
NM_001883.4
NCBI Official Full Name
corticotropin-releasing factor receptor 2 isoform 1
NCBI Official Synonym Full Names
corticotropin releasing hormone receptor 2
NCBI Official Symbol
CRHR2
NCBI Official Synonym Symbols
CRF2; CRFR2; CRF-RB; HM-CRF
UniProt Protein Name
Corticotropin-releasing factor receptor 2
UniProt Synonym Protein Names
Corticotropin-releasing hormone receptor 2; CRH-R-2; CRH-R2
Protein Family
Corticotropin-releasing factor receptor
UniProt Gene Name
CRHR2
UniProt Synonym Gene Names
CRF2R; CRH2R; CRF-R-2; CRF-R2; CRFR-2; CRH-R-2; CRH-R2
UniProt Entry Name
CRFR2_HUMAN
NCBI Protein Information
corticotropin-releasing factor receptor 2; CRH-R2; CRH receptor 2 variant B; CRF2 receptor, beta isoform

NCBI Summary for CRHR2

The protein encoded by this gene belongs to the G-protein coupled receptor 2 family, and the subfamily of corticotropin releasing hormone receptor. This receptor shows high affinity for corticotropin releasing hormone (CRH), and also binds CRH-related peptides such as urocortin. CRH is synthesized in the hypothalamus, and plays an important role in coordinating the endocrine, autonomic, and behavioral responses to stress and immune challenge. Studies in mice suggest that this receptor maybe involved in mediating cardiovascular homeostasis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jan 2011]
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UniProt Comments for CRHR2

CRHR2: This is a receptor for corticotropin releasing factor. Shows high-affinity CRF binding. Also binds to urocortin I, II and III. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Belongs to the G-protein coupled receptor 2 family. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 2

Chromosomal Location of Human Ortholog: 7p14.3

Cellular Component: Golgi apparatus; cell surface; integral to plasma membrane; endoplasmic reticulum; plasma membrane

Molecular Function: protein binding; hormone activity; corticotrophin-releasing factor receptor activity

Biological Process: G-protein signaling, coupled to cAMP nucleotide second messenger; negative regulation of angiogenesis
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Research Articles on CRHR2

1. Results suggest CRHR-2 variants may affect risk for PTSD in women by attenuating the stress response and reducing symptoms of the disorder.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CRHR2 antibody

 Reference Product  PubMed Publications
 CRH antibody  >79 publications with CRHR2 and CRH
 UCN antibody  >22 publications with CRHR2 and UCN
 UCN3 antibody  >10 publications with CRHR2 and UCN3
 POMC antibody  >9 publications with CRHR2 and POMC
 UCN2 antibody  >9 publications with CRHR2 and UCN2
 GHRHR antibody  >1 publications with CRHR2 and GHRHR

Pathways associated with anti-CRHR2 antibody

 Products by Pathway  Pathway Diagram
 Class B/2 (Secretin Family Receptors) Pathway antibodies  Class B/2 (Secretin Family Receptors) Pathway Diagram
 Corticotropin-releasing Hormone Pathway antibodies  Corticotropin-releasing Hormone Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (s) Signalling Events Pathway antibodies  G Alpha (s) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class B Secretin-like Pathway antibodies  GPCRs, Class B Secretin-like Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-CRHR2 antibody

 Disease Name  Pubmed Publications
 Anxiety Disorders Antibodies  >13 publications with CRHR2 and Anxiety Disorders
 Inflammation Antibodies  >8 publications with CRHR2 and Inflammation
 Depressive Disorder Antibodies  >7 publications with CRHR2 and Depressive Disorder
 Necrosis Antibodies  >7 publications with CRHR2 and Necrosis
 Cardiovascular Diseases Antibodies  >7 publications with CRHR2 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >6 publications with CRHR2 and Disease Models, Animal
 Weight Loss Antibodies  >5 publications with CRHR2 and Weight Loss
 Weight Gain Antibodies  >4 publications with CRHR2 and Weight Gain
 Liver Diseases Antibodies  >3 publications with CRHR2 and Liver Diseases
 Lung Diseases Antibodies  >3 publications with CRHR2 and Lung Diseases

Organs/Tissues associated with anti-CRHR2 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >52 publications with CRHR2 and Brain
 Uterus Antibodies  >2 publications with CRHR2 and Uterus
 Embryonic Tissue Antibodies  >2 publications with CRHR2 and Embryonic Tissue
 Kidney Antibodies  >1 publications with CRHR2 and Kidney
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