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CHRM5 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247347

Muscarinic cholinergic receptor M5 is an Acetylcholine Receptor that is active during embryonic development. It is coupled to phosphoinositide degradation and to the activation of mitogen-activated protein kinase (MAPK). More details

$630 / 0.05 mg +1 FREE 8GB USB
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Sample Manual Insert View PDF
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Testing Data View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
CHRM5 / M5, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human CHRM5 / M5
Product Gene Name
anti-CHRM5 antibody
Product Synonym Names
Anti-CHRM5 / M5 Antibody (Cytoplasmic Domain) IHC-plus; CHRM5; M5 muscarinic receptor; Muscarinic m5 receptor; Muscarinic receptor M5; HM5; Human CHRM5; M5
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gorilla, Human, Monkey
Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human CHRM5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
60,074 Da
OMIM
118496
3D Structure
ModBase 3D Structure for P08912
Target Species
Human
Immunogen Description
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human CHRM5. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Gibbon (94%); Chimpanzee, Marmoset (88%); Dog, Bovine, Panda, Horse (81%).
Immunogen Type
Synthetic peptide
Immunogen
CHRM5 / M5 antibody was raised against synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human CHRM5. Percent identity with other species by BLAST analysis: Human, Gorilla, Monkey (100%); Gibbon (94%); Chimpanzee, Marmoset (88%); Dog, Bovine, Panda, Horse (81%).
Antigen Modification
Cytoplasmic Domain

Product Categories/Family for anti-CHRM5 antibody

Family: GPCR; Subfamily: Acetylcholine
Applications Tested/Suitable for anti-CHRM5 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-CHRM5 antibody
IHC-P (6 ug/ml)

Immunohistochemistry (IHC) of anti-CHRM5 antibody

Anti-CHRM5 antibody IHC of human brain, vessel. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-CHRM5 Polyclonal Antibody – Cat# MBS247347

Immunohistochemistry (IHC) of anti-CHRM5 antibody

Anti-CHRM5 / M5 antibody IHC of human Lung, Small Cell Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-CHRM5 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247347

Other Notes

Small volumes of anti-CHRM5 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for CHRM5 purchase

MBS247347 is an antibody targeting CHRM5. Also known as Rabbit Polyclonal to Human CHRM5 / M5. Reactive in Gorilla, Human, Monkey
Predicted Reactivity: Gibbon (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for CHRM5. It may not necessarily be applicable to this product.

NCBI GI #
7108336
NCBI GeneID
1133
NCBI Accession #
NP_036257.1
UniProt Primary Accession #
P08912
UniProt Secondary Accession #
Q96RG7
UniProt Related Accession #
P08912
GenBank Nucleotide #
NM_012125.3
NCBI Official Full Name
muscarinic acetylcholine receptor M5
NCBI Official Synonym Full Names
cholinergic receptor, muscarinic 5
NCBI Official Symbol
CHRM5
NCBI Official Synonym Symbols
HM5
UniProt Protein Name
Muscarinic acetylcholine receptor M5
Protein Family
Muscarinic acetylcholine receptor
UniProt Gene Name
CHRM5
UniProt Entry Name
ACM5_HUMAN
NCBI Protein Information
muscarinic acetylcholine receptor M5; acetylcholine receptor, muscarinic 5

NCBI Summary for CHRM5

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor are unknown; however, stimulation of this receptor is known to increase cyclic AMP levels. [provided by RefSeq, Jul 2008]
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UniProt Comments for CHRM5

mAChR M5: The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM5 sub-subfamily.

Protein type: Membrane protein, integral; Receptor, GPCR; GPCR, family 1; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 15q26

Cellular Component: postsynaptic membrane; integral to plasma membrane; plasma membrane; cell junction

Molecular Function: phosphoinositide phospholipase C activity; G-protein coupled acetylcholine receptor activity

Biological Process: cell proliferation; gastric acid secretion; dopamine transport; acetylcholine receptor signaling, muscarinic pathway; metabolic process; muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway; transmission of nerve impulse
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Research Articles on CHRM5

1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-CHRM5 antibody

 Reference Product  PubMed Publications
 CHRM3 antibody  >6 publications with CHRM5 and CHRM3
 TACR1 antibody  >1 publications with CHRM5 and TACR1

Pathways associated with anti-CHRM5 antibody

 Products by Pathway  Pathway Diagram
 Amine Ligand-binding Receptors Pathway antibodies  Amine Ligand-binding Receptors Pathway Diagram
 Calcium Regulation In The Cardiac Cell Pathway antibodies  Calcium Regulation In The Cardiac Cell Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Cholinergic Synapse Pathway antibodies  Cholinergic Synapse Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 G Alpha (q) Signalling Events Pathway antibodies  G Alpha (q) Signalling Events Pathway Diagram
 GPCR Downstream Signaling Pathway antibodies  GPCR Downstream Signaling Pathway Diagram

Diseases associated with anti-CHRM5 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >2 publications with CHRM5 and Nervous System Diseases
 Fibrosis Antibodies  >1 publications with CHRM5 and Fibrosis
 Pain Antibodies  >1 publications with CHRM5 and Pain

Organs/Tissues associated with anti-CHRM5 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >2 publications with CHRM5 and Brain
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