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VRL1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247365

Transient Receptor Potential Vanilloid (TRPV) channels are widely expressed in both sensory and nonsensory cells. TRPV2, a member of transient receptor potential ion channels, responds to high-threshold noxious heat (with a threshold of approximately 52… More details

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Product Overview

Online Datasheet in PDF
Product Name
VRL1 / TRPV2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human VRL1 / TRPV2
Product Gene Name
anti-VRL1 antibody
Product Synonym Gene Name
TRPV2
Product Synonym Names
Anti-VRL1 / TRPV2 Antibody (Internal) IHC-plus; TRPV2; GRC; OTRPC2; Osm-9-like TRP channel 2; VRL-1; VRL1; VRL; Human VRL1; TRPV2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Predicted Reactivity: Chimpanzee, Orangutan (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human TRPV2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
85,981 Da
OMIM
606676
3D Structure
ModBase 3D Structure for Q9Y5S1
Target Species
Human
Immunogen Description
Synthetic 15 amino acid peptide from internal region of human TRPV2. Percent identity with other species by BLAST analysis: Human (100%); Chimpanzee, Orangutan (93%); Gibbon, Monkey (80%).
Immunogen Type
Synthetic peptide
Immunogen
VRL1 / TRPV2 antibody was raised against synthetic 15 amino acid peptide from internal region of human TRPV2. Percent identity with other species by BLAST analysis: Human (100%); Chimpanzee, Orangutan (93%); Gibbon, Monkey (80%).
Antigen Modification
Internal

Product Categories/Family for anti-VRL1 antibody

Family: Ion Channel; Subfamily: Calcium channel - TRP
Applications Tested/Suitable for anti-VRL1 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-VRL1 antibody
IHC-P (5 ug/ml)
Usage: Antigen retrieval requires Proteinase K treatment.

Immunohistochemistry (IHC) of anti-VRL1 antibody

Anti-TRPV2 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-VRL1 Polyclonal Antibody – Cat# MBS247365

Immunohistochemistry (IHC) of anti-VRL1 antibody

Anti-TRPV2 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-VRL1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247365

Other Notes

Small volumes of anti-VRL1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for VRL1 purchase

MBS247365 is an antibody targeting VRL1. Also known as Rabbit Polyclonal to Human VRL1 / TRPV2. Reactive in Human
Predicted Reactivity: Chimpanzee, Orangutan (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for VRL1. It may not necessarily be applicable to this product.

NCBI GI #
20127551
NCBI GeneID
51393
NCBI Accession #
NP_057197.2
UniProt Primary Accession #
Q9Y5S1
UniProt Secondary Accession #
Q9Y670; A6NML2; A8K0Z0
UniProt Related Accession #
Q9Y5S1
GenBank Nucleotide #
NM_016113.4
NCBI Official Full Name
transient receptor potential cation channel subfamily V member 2
NCBI Official Synonym Full Names
transient receptor potential cation channel, subfamily V, member 2
NCBI Official Symbol
TRPV2
NCBI Official Synonym Symbols
VRL; VRL1; VRL-1
UniProt Protein Name
Transient receptor potential cation channel subfamily V member 2
UniProt Synonym Protein Names
Osm-9-like TRP channel 2; OTRPC2; Vanilloid receptor-like protein 1; VRL-1
UniProt Gene Name
TRPV2
UniProt Synonym Gene Names
VRL; TrpV2; OTRPC2; VRL-1
UniProt Entry Name
TRPV2_HUMAN
NCBI Protein Information
transient receptor potential cation channel subfamily V member 2; OTRPC2; osm-9-like TRP channel 2; vanilloid receptor-like protein 1

NCBI Summary for VRL1

This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]
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UniProt Comments for VRL1

TRPV2: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV2 sub-subfamily.

Protein type: Membrane protein, multi-pass; Channel, cation; Membrane protein, integral

Chromosomal Location of Human Ortholog: 17p11.2

Cellular Component: cell surface; integral to plasma membrane; melanosome; plasma membrane; endomembrane system

Molecular Function: calcium channel activity; ion transmembrane transporter activity; ion channel activity; cation channel activity

Biological Process: response to temperature stimulus; response to heat; transport; positive regulation of axon extension; sensory perception; transmembrane transport
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Research Articles on VRL1

1. An upregulation in the expression of vanilloid transient potential channels 2 enhances hypotonicity-induced cytosolic Ca(2) rise in human induced pluripotent stem cell model of Hutchinson-Gillford Progeria.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-VRL1 antibody

 Reference Product  PubMed Publications
 TRPV1 antibody  >175 publications with VRL1 and TRPV1
 TRPM8 antibody  >60 publications with VRL1 and TRPM8
 TRPM4 antibody  >24 publications with VRL1 and TRPM4
 TRPM7 antibody  >21 publications with VRL1 and TRPM7
 TRPC6 antibody  >16 publications with VRL1 and TRPC6
 TRPM3 antibody  >15 publications with VRL1 and TRPM3
 TRPC4 antibody  >13 publications with VRL1 and TRPC4
 TRPC3 antibody  >11 publications with VRL1 and TRPC3
 TRPC5 antibody  >4 publications with VRL1 and TRPC5

Pathways associated with anti-VRL1 antibody

 Products by Pathway  Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Inflammatory Mediator Regulation Of TRP Channels Pathway antibodies  Inflammatory Mediator Regulation Of TRP Channels Pathway Diagram
 Ion Channel Transport Pathway antibodies  Ion Channel Transport Pathway Diagram
 Stimuli-sensing Channels Pathway antibodies  Stimuli-sensing Channels Pathway Diagram
 TRP Channels Pathway antibodies  TRP Channels Pathway Diagram
 Transmembrane Transport Of Small Molecules Pathway antibodies  Transmembrane Transport Of Small Molecules Pathway Diagram

Diseases associated with anti-VRL1 antibody

 Disease Name  Pubmed Publications
 Pain Antibodies  >58 publications with VRL1 and Pain
 Nervous System Diseases Antibodies  >32 publications with VRL1 and Nervous System Diseases
 Inflammation Antibodies  >23 publications with VRL1 and Inflammation
 Hyperalgesia Antibodies  >15 publications with VRL1 and Hyperalgesia
 Disease Models, Animal Antibodies  >13 publications with VRL1 and Disease Models, Animal
 Heart Diseases Antibodies  >8 publications with VRL1 and Heart Diseases
 Necrosis Antibodies  >6 publications with VRL1 and Necrosis
 Hypertension Antibodies  >4 publications with VRL1 and Hypertension
 Fibrosis Antibodies  >3 publications with VRL1 and Fibrosis
 Cardiomyopathies Antibodies  >3 publications with VRL1 and Cardiomyopathies

Organs/Tissues associated with anti-VRL1 antibody

 Organ/Tissue Name  Pubmed Publications
 Nerve Antibodies  >54 publications with VRL1 and Nerve
 Brain Antibodies  >42 publications with VRL1 and Brain
 Muscle Antibodies  >38 publications with VRL1 and Muscle
 Skin Antibodies  >34 publications with VRL1 and Skin
 Blood Antibodies  >29 publications with VRL1 and Blood
 Vascular Antibodies  >26 publications with VRL1 and Vascular
 Heart Antibodies  >17 publications with VRL1 and Heart
 Bladder Antibodies  >16 publications with VRL1 and Bladder
 Lung Antibodies  >13 publications with VRL1 and Lung
 Kidney Antibodies  >11 publications with VRL1 and Kidney
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