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GC Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247429

MBS247429 is an antibody targeting GC. Also known as Rabbit Polyclonal (IgG) to Human GC / Vitamin D-Binding Protein. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
GC / Vitamin D-Binding Protein, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human GC / Vitamin D-Binding Protein
Product Gene Name
anti-GC antibody
Product Synonym Names
Anti-GC / Vitamin D-Binding Protein Antibody IHC-plus; GC; Gc-globulin; HDBP; Group-specific component; GRD3; VDB; VDBG; VDBP; Vitamin D-binding protein; Human GC; Vitamin D-Binding Protein
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS, 0.09% sodium azide.
Purity/Purification
Protein G Purified
Concentration
5 mg/ml (lot specific)
Specificity
Recognizes Vitamin D binding protein (VDBP), the major carrier protein of vitamin D that also transports components such as fatty acids and endotoxins and has an important role in the actin scavenging system. VDBP is a 52-58 kD plasma protein synthesized mainly by hepatocytes. Polymorphisms in the gene give rise to three major electrophoretic variants, Gc1, Gc1s and Gc1f that differ by amino acid substitutions as well as glycosylations. The physiological significance of these phenotypes has yet to be determined.
Preparation and Storage
+4 degree C or -20 degree C, Avoid repeated freezing and thawing.
Molecular Weight
55,123 Da
OMIM
139200
3D Structure
ModBase 3D Structure for P02774
Target Species
Human
Immunogen Description
Native human vitamin D binding protein.
Immunogen
GC / Vitamin D-Binding Protein antibody was raised against native human vitamin D binding protein.
Applications Tested/Suitable for anti-GC antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-GC antibody
ELISA, IHC-P (5 ug/ml)

Immunohistochemistry (IHC) of anti-GC antibody

Anti-GC / VDBP antibody IHC of human blood plasma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-GC Polyclonal Antibody – Cat# MBS247429

Immunohistochemistry (IHC) of anti-GC antibody

Anti-GC / VDBP antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.
Rabbit Anti-GC Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247429

Other Notes

Small volumes of anti-GC antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for GC. It may not necessarily be applicable to this product.

NCBI GI #
32483410
NCBI GeneID
2638
NCBI Accession #
NP_000574.2
UniProt Primary Accession #
P02774
UniProt Secondary Accession #
Q16309; Q16310; Q53F31; Q6GTG1; B4DPP2; D6RAK8
UniProt Related Accession #
P02774
GenBank Nucleotide #
NM_000583.3
NCBI Official Full Name
vitamin D-binding protein isoform 1
NCBI Official Synonym Full Names
group-specific component (vitamin D binding protein)
NCBI Official Symbol
GC
NCBI Official Synonym Symbols
DBP; GRD3; VDBG; VDBP; DBP/GC; HEL-S-51
UniProt Protein Name
Vitamin D-binding protein
UniProt Synonym Protein Names
Gc-globulin; Group-specific component
Protein Family
Envelope glycoprotein
UniProt Gene Name
GC
UniProt Synonym Gene Names
DBP; VDB
UniProt Entry Name
VTDB_HUMAN
NCBI Protein Information
vitamin D-binding protein; VDB; gc-globulin; vitamin D-binding alpha-globulin; epididymis secretory protein Li 51

NCBI Summary for GC

The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
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UniProt Comments for GC

GC: Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. Belongs to the ALB/AFP/VDB family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 4q12-q13

Cellular Component: extracellular space; lysosomal lumen; extracellular region; cytosol

Molecular Function: vitamin D binding; actin binding; vitamin transporter activity

Biological Process: steroid metabolic process; vitamin transport; vitamin D metabolic process

Disease: Graves Disease, Susceptibility To, 1
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Research Articles on GC

1. genetic differences in the VDR gene may be involved in the development of AITD and the activity of GD, whereas the genetic differences in the GC and CYP2R1 genes may be involved with the intractability of GD.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GC antibody

 Reference Product  PubMed Publications
 CYP2R1 antibody  >65 publications with GC and CYP2R1
 AHSG antibody  >21 publications with GC and AHSG
 AMBP antibody  >3 publications with GC and AMBP
 SLC25A18 antibody  >1 publications with GC and SLC25A18
 C5AR1 antibody  >1 publications with GC and C5AR1
 LRP2 antibody  >1 publications with GC and LRP2

Pathways associated with anti-GC antibody

 Products by Pathway  Pathway Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram
 Metabolism Of Steroid Hormones And Vitamin D Pathway antibodies  Metabolism Of Steroid Hormones And Vitamin D Pathway Diagram
 Vitamin D (calciferol) Metabolism Pathway antibodies  Vitamin D (calciferol) Metabolism Pathway Diagram
 Vitamin D Synthesis Pathway antibodies  Vitamin D Synthesis Pathway Diagram

Diseases associated with anti-GC antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >1105 publications with GC and Inflammation
 Brain Diseases Antibodies  >1085 publications with GC and Brain Diseases
 Lung Diseases Antibodies  >766 publications with GC and Lung Diseases
 Poisoning Antibodies  >728 publications with GC and Poisoning
 Necrosis Antibodies  >686 publications with GC and Necrosis
 Liver Diseases Antibodies  >683 publications with GC and Liver Diseases
 Kidney Diseases Antibodies  >433 publications with GC and Kidney Diseases
 Heart Diseases Antibodies  >402 publications with GC and Heart Diseases
 Hypertension Antibodies  >380 publications with GC and Hypertension
 Wounds and Injuries Antibodies  >360 publications with GC and Wounds and Injuries

Organs/Tissues associated with anti-GC antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >9849 publications with GC and Blood
 Liver Antibodies  >3005 publications with GC and Liver
 Muscle Antibodies  >1474 publications with GC and Muscle
 Kidney Antibodies  >1349 publications with GC and Kidney
 Lung Antibodies  >1291 publications with GC and Lung
 Heart Antibodies  >1047 publications with GC and Heart
 Intestine Antibodies  >751 publications with GC and Intestine
 Ovary Antibodies  >715 publications with GC and Ovary
 Connective Tissue Antibodies  >588 publications with GC and Connective Tissue
 Spleen Antibodies  >526 publications with GC and Spleen
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