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FUZ Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247435

MBS247435 is an antibody targeting FUZ. Also known as Rabbit Polyclonal (IgG) to Human FUZ / FY. Reactive in Gibbon, Gorilla, Human, Mouse, RatPredicted Reactivity: Monkey (at least 90% immunogen sequence identity). Host: Rabbit. More details

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Product Overview

Product Name
FUZ / FY, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human FUZ / FY
Product Gene Name
anti-FUZ antibody
Product Synonym Gene Name
FY
Product Synonym Names
Anti-FUZ / FY Antibody (aa338-355) IHC-plus; FUZ; FY; Fuzzy homolog (Drosophila); NTD; Protein fuzzy homolog; Human FUZ; FY
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human, Mouse, Rat
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.05% BSA, 0.05% sodium azide
Purity/Purification
Protein G Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human FUZ
Preparation and Storage
Store at 4 degree C for short term applications. For long term storage, aliquot and store at -20 degree C.
Molecular Weight
41,591 Da
OMIM
610622
3D Structure
ModBase 3D Structure for Q9BT04
Target Species
Human
Immunogen Description
A synthetic peptide corresponding to amino acids 338-355 (TSTHFPPEPGPPEKTEDE) of human FUZ was used as immunogen, GenBank no NP_079405.2.
Immunogen Type
Synthetic peptide
Immunogen
FUZ / FY antibody was raised against a synthetic peptide corresponding to amino acids 338-355 (TSTHFPPEPGPPEKTEDE) of human FUZ was used as immunogen, GenBank no NP_079405.2. Percent identity by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (94%); Marmoset (89%).
Antigen Modification
aa338-355
Applications Tested/Suitable for anti-FUZ antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB)
Application Notes for anti-FUZ antibody
IHC-P (15 ug/ml), WB (2 - 6 ug/ml)

Immunohistochemistry (IHC) of anti-FUZ antibody

Anti-FUZ / FY antibody IHC of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody dilution 15 ug/ml.
Rabbit Anti-FUZ Polyclonal Antibody – Cat# MBS247435

Western Blot (WB) of anti-FUZ antibody

Western blot of FUZ in human lung lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse lung and 4) rat lung using at 2.0 ug/ml, 2.0 ug/ml and 6.0 ug/ml respectively.
Rabbit Anti-FUZ Polyclonal Antibody, Western Blot (WB) – Cat# MBS247435

Other Notes

Small volumes of anti-FUZ antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for FUZ. It may not necessarily be applicable to this product.

NCBI GI #
20149693
NCBI GeneID
80199
NCBI Accession #
NP_079405.2
UniProt Primary Accession #
Q9BT04
UniProt Secondary Accession #
Q6PJY0; Q9H613; B2RD86; B5MDH0
UniProt Related Accession #
Q9BT04
GenBank Nucleotide #
NM_025129.4
NCBI Official Full Name
protein fuzzy homolog isoform 1
NCBI Official Synonym Full Names
fuzzy planar cell polarity protein
NCBI Official Symbol
FUZ
NCBI Official Synonym Symbols
FY; NTD
UniProt Protein Name
Protein fuzzy homolog
Protein Family
Protein fuzzy
UniProt Gene Name
FUZ
UniProt Synonym Gene Names
FY
UniProt Entry Name
FUZZY_HUMAN
NCBI Protein Information
protein fuzzy homolog

NCBI Summary for FUZ

This gene encodes a planar cell polarity protein that is involved in ciliogenesis and directional cell movement. Knockout studies in mice exhibit neural tube defects and defective cilia, and mutations in this gene are associated with neural tube defects in humans. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]
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UniProt Comments for FUZ

FUZ: Probable planar cell polarity effector involved in cilium biogenesis. May regulate protein and membrane transport to the cilium. May regulate the morphogenesis of hair follicles which depends on functional primary cilia. Belongs to the fuzzy family. 3 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 19q13.33

Cellular Component: cytoskeleton; cytoplasm

Biological Process: spinal cord dorsal/ventral patterning; embryonic skeletal morphogenesis; negative regulation of cell proliferation; embryonic body morphogenesis; protein transport; hair follicle development; sensory cilium biogenesis; neural tube closure; cilium biogenesis; establishment of planar polarity; negative regulation of cell migration; positive regulation of flagellum biogenesis; regulation of smoothened signaling pathway

Disease: Neural Tube Defects
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Research Articles on FUZ

1. Data propose that mutations in Fuzzy may account for a subset of neural tube defects in humans.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-FUZ antibody

 Reference Product  PubMed Publications
 INTU antibody  >2 publications with FUZ and INTU

Pathways associated with anti-FUZ antibody

 Products by Pathway  Pathway Diagram
 Hedgehog 'off' State Pathway antibodies  Hedgehog 'off' State Pathway Diagram
 Signal Transduction Pathway antibodies  Signal Transduction Pathway Diagram
 Signaling By Hedgehog Pathway antibodies  Signaling By Hedgehog Pathway Diagram

Diseases associated with anti-FUZ antibody

 Disease Name  Pubmed Publications
 Neural Tube Defects Antibodies  >5 publications with FUZ and Neural Tube Defects
 Congenital Abnormalities Antibodies  >5 publications with FUZ and Congenital Abnormalities
 Movement Disorders Antibodies  >1 publications with FUZ and Movement Disorders
 Skin Diseases Antibodies  >1 publications with FUZ and Skin Diseases
 Depressive Disorder Antibodies  >1 publications with FUZ and Depressive Disorder
 Brain Diseases Antibodies  >1 publications with FUZ and Brain Diseases
 Disease Models, Animal Antibodies  >1 publications with FUZ and Disease Models, Animal

Organs/Tissues associated with anti-FUZ antibody

 Organ/Tissue Name  Pubmed Publications
 Blood Antibodies  >4 publications with FUZ and Blood
 Embryonic Tissue Antibodies  >3 publications with FUZ and Embryonic Tissue
 Bone Antibodies  >2 publications with FUZ and Bone
 Nerve Antibodies  >1 publications with FUZ and Nerve
 Mouth Antibodies  >1 publications with FUZ and Mouth
 Skin Antibodies  >1 publications with FUZ and Skin
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