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RCAN2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247453

MBS247453 is an antibody targeting RCAN2. Also known as Rabbit Polyclonal to Human RCAN2 / RCN2. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
RCAN2 / RCN2, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human RCAN2 / RCN2
Product Gene Name
Product Synonym Gene Name
RCN2
Product Synonym Names
Anti-RCAN2 / RCN2 Antibody (Internal) IHC-plus; RCAN2; Calcipressin-2; CSP2; DSCR1L1; HRCN2; ZAKI-4; ZAKI4; MCIP2; Regulator of calcineurin 2; Human RCAN2; RCN2
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human RCAN2
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
27,289 Da
OMIM
604876
3D Structure
ModBase 3D Structure for Q14206
Target Species
Human
Immunogen Description
A 14 amino acid peptide near the center of human RCAN2.
Immunogen Type
Synthetic peptide
Immunogen
RCAN2 / RCN2 antibody was raised against a 14 amino acid peptide near the center of human RCAN2.
Antigen Modification
Internal
Applications Tested/Suitable for anti-RCAN2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-RCAN2 antibody
ELISA, IHC-P (3 ug/ml), WB (1 - 2 ug/ml)
Usage: RCAN2 antibody can be used for detection of RCAN2 by Western blot at 1-2 ug/ml.

Immunohistochemistry (IHC) of anti-RCAN2 antibody

Anti-RCAN2 antibody IHC of human endometrium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.
Rabbit Anti-RCAN2 Polyclonal Antibody – Cat# MBS247453

Immunohistochemistry (IHC) of anti-RCAN2 antibody

Anti-RCAN2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3 ug/ml.
Rabbit Anti-RCAN2 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247453

Immunofluorescence (IF) of anti-RCAN2 antibody

Immunofluorescence of RCAN2 in mouse brain tissue with RCAN2 antibody at 20 ug/ml.
Rabbit Anti-RCAN2 Polyclonal Antibody, Immunofluorescence (IF) – Cat# MBS247453

Western Blot (WB) of anti-RCAN2 antibody

Western blot of RCAN2 in 3T3 cell lysate with RCAN2 antibody at (A) 1 and (B) 2 ug/ml.
Rabbit Anti-RCAN2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS247453

Other Notes

Small volumes of anti-RCAN2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for RCAN2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
calcipressin-2 isoform 1
NCBI Official Synonym Full Names
regulator of calcineurin 2
NCBI Official Symbol
RCAN2
NCBI Official Synonym Symbols
CSP2; RCN2; MCIP2; ZAKI4; ZAKI-4; DSCR1L1
UniProt Protein Name
Calcipressin-2
UniProt Synonym Protein Names
Down syndrome candidate region 1-like 1; Myocyte-enriched calcineurin-interacting protein 2; MCIP2; Regulator of calcineurin 2; Thyroid hormone-responsive protein ZAKI-4
Protein Family
UniProt Gene Name
RCAN2
UniProt Synonym Gene Names
DSCR1L1; ZAKI4; MCIP2
UniProt Entry Name
RCAN2_HUMAN
NCBI Protein Information
calcipressin-2; Down syndrome candidate region 1-like 1; thyroid hormone-responsive protein ZAKI-4; Down syndrome critical region gene 1-like 1; thyroid hormone-responsive (skin fibroblasts); myocyte-enriched calcineurin-interacting protein 2

NCBI Summary for RCAN2

This gene encodes a member of the regulator of calcineurin (RCAN) protein family. These proteins play a role in many physiological processes by binding to the catalytic domain of calcineurin A, inhibiting calcineurin-mediated nuclear translocation of the transcription factor NFATC1. Expression of this gene in skin fibroblasts is upregulated by thyroid hormone, and the encoded protein may also play a role in endothelial cell function and angiogenesis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
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UniProt Comments for RCAN2

RCAN2: Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. Belongs to the RCAN family. 2 isoforms of the human protein are produced by alternative splicing.

Chromosomal Location of Human Ortholog: 6p12.3

Molecular Function: nucleotide binding

Biological Process: calcineurin-NFAT signaling pathway; short-term memory; response to oxidative stress; locomotion during locomotory behavior
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-RCAN2 antibody

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