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MER Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247511

Mer, an Axl type tyrosine kinase, contains a cell adhesion molecule-related extracellular domain. Mutation of Mer results in defective phagocytosis of photoreceptor outer segments by the retinal pigment epithelium (RPE) and retinal degeneration. In addition,… More details

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Product Overview

Online Datasheet in PDF
Product Name
MER / MERTK, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human MER / MERTK
Product Gene Name
anti-MER antibody
Product Synonym Gene Name
MERTK
Product Synonym Names
Anti-MER / MERTK Antibody (C-Terminus) IHC-plus; MERTK; Eyk; MER; MER receptor tyrosine kinase; Nyk; Proto-oncogene c-Mer; RP38; STK kinase; C-mer; Receptor tyrosine kinase MerTK; Tyrosine-protein kinase Mer; Human MER; MERTK
Clonality
Polyclonal
Host
Goat
Species Reactivity
Gibbon, Gorilla, Human, Orangutan
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human MERTK.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
110,249 Da
OMIM
gene 613862
3D Structure
ModBase 3D Structure for Q12866
Target Species
Human
Immunogen Description
Synthetic peptide C-DSSEGSEVLM from the C-terminus of human MERTK (NP_006334.2). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon (100%); Monkey, Opossum (90%); Marmoset, Elephant, Turkey, Chicken, Lizard, Drosophila, Nematode (80%).
Immunogen Type
Synthetic peptide
Immunogen
MER / MERTK antibody was raised against synthetic peptide C-DSSEGSEVLM from the C-terminus of human MERTK (NP_006334.2). Percent identity by BLAST analysis: Human, Gorilla, Orangutan, Gibbon (100%); Monkey, Opossum (90%); Marmoset, Elephant, Turkey, Chicken, Lizard, Drosophila, Nematode (80%).
Antigen Modification
C-Terminus

Product Categories/Family for anti-MER antibody

Family: Protein Kinase; Subfamily: Axl
Applications Tested/Suitable for anti-MER antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-MER antibody
ELISA (1:2000), IHC-P (3.75 ug/ml)

Immunohistochemistry (IHC) of anti-MER antibody

Anti-MERTK antibody IHC of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-MER Polyclonal Antibody – Cat# MBS247511

Other Notes

Small volumes of anti-MER antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MER purchase

MBS247511 is an antibody targeting MER. Also known as Goat Polyclonal to Human MER / MERTK. Reactive in Gibbon, Gorilla, Human, Orangutan
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity). Host: Goat.

Additional Details

NCBI/Uniprot data below describe general gene information for MER. It may not necessarily be applicable to this product.

NCBI GI #
66932918
NCBI GeneID
10461
NCBI Accession #
NP_006334.2
UniProt Primary Accession #
Q12866
UniProt Secondary Accession #
Q9HBB4
UniProt Related Accession #
Q12866
GenBank Nucleotide #
NM_006343.2
NCBI Official Full Name
tyrosine-protein kinase Mer
NCBI Official Synonym Full Names
MER proto-oncogene, tyrosine kinase
NCBI Official Symbol
MERTK
NCBI Official Synonym Symbols
MER; RP38; c-Eyk; c-mer; Tyro12
UniProt Protein Name
Tyrosine-protein kinase Mer
UniProt Synonym Protein Names
Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK
Protein Family
5,10-methylenetetrahydromethanopterin reductase
UniProt Gene Name
MERTK
UniProt Synonym Gene Names
MER
UniProt Entry Name
MERTK_HUMAN
NCBI Protein Information
tyrosine-protein kinase Mer; STK kinase; proto-oncogene c-Mer; MER receptor tyrosine kinase; receptor tyrosine kinase MerTK; c-mer proto-oncogene tyrosine kinase

NCBI Summary for MER

This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]
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UniProt Comments for MER

Mer: a proto-oncogene receptor tyrosine-protein kinase of the Axl family. Binds several ligands including LGALS3, Tubby, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3

Protein type: Membrane protein, integral; Protein kinase, tyrosine (receptor); Protein kinase, TK; Kinase, protein; EC 2.7.10.1; Oncoprotein; TK group; Axl family

Chromosomal Location of Human Ortholog: 2q14.1

Cellular Component: extracellular space; photoreceptor outer segment; integral to plasma membrane; cytoplasm; plasma membrane

Molecular Function: protein binding; transmembrane receptor protein tyrosine kinase activity; ATP binding

Biological Process: platelet activation; negative regulation of lymphocyte activation; peptidyl-tyrosine phosphorylation; vagina development; protein amino acid phosphorylation; phagocytosis; cell surface receptor linked signal transduction; cell-cell signaling; retina development in camera-type eye; natural killer cell differentiation; positive regulation of phagocytosis; protein kinase B signaling cascade; spermatogenesis; blood coagulation; leukocyte migration; apoptotic cell clearance; secretion by cell

Disease: Retinitis Pigmentosa 38
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Research Articles on MER

1. The MER receptor pathway promotes wound repair in macrophages and epithelial cell growth.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MER antibody

 Reference Product  PubMed Publications
 GAS6 antibody  >75 publications with MER and GAS6
 RPE65 antibody  >14 publications with MER and RPE65
 GRB2 antibody  >3 publications with MER and GRB2
 VAV1 antibody  >2 publications with MER and VAV1
 SEMA4C antibody  >1 publications with MER and SEMA4C
 DFNB59 antibody  >1 publications with MER and DFNB59
 DDR1 antibody  >1 publications with MER and DDR1
 PIK3R1 antibody  >1 publications with MER and PIK3R1

Pathways associated with anti-MER antibody

 Products by Pathway  Pathway Diagram
 Cell Surface Interactions At The Vascular Wall Pathway antibodies  Cell Surface Interactions At The Vascular Wall Pathway Diagram
 Hemostasis Pathway antibodies  Hemostasis Pathway Diagram

Diseases associated with anti-MER antibody

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >53 publications with MER and Inflammation
 Retinitis Pigmentosa Antibodies  >41 publications with MER and Retinitis Pigmentosa
 Disease Models, Animal Antibodies  >39 publications with MER and Disease Models, Animal
 Nervous System Diseases Antibodies  >26 publications with MER and Nervous System Diseases
 Necrosis Antibodies  >24 publications with MER and Necrosis
 Nerve Degeneration Antibodies  >10 publications with MER and Nerve Degeneration
 Lymphoma Antibodies  >10 publications with MER and Lymphoma
 Thrombosis Antibodies  >10 publications with MER and Thrombosis
 Cell Transformation, Neoplastic Antibodies  >8 publications with MER and Cell Transformation, Neoplastic
 Liver Diseases Antibodies  >7 publications with MER and Liver Diseases

Organs/Tissues associated with anti-MER antibody

 Organ/Tissue Name  Pubmed Publications
 Eye Antibodies  >89 publications with MER and Eye
 Blood Antibodies  >84 publications with MER and Blood
 Bone Antibodies  >35 publications with MER and Bone
 Brain Antibodies  >27 publications with MER and Brain
 Lung Antibodies  >16 publications with MER and Lung
 Testis Antibodies  >11 publications with MER and Testis
 Liver Antibodies  >10 publications with MER and Liver
 Muscle Antibodies  >9 publications with MER and Muscle
 Kidney Antibodies  >7 publications with MER and Kidney
 Embryonic Tissue Antibodies  >6 publications with MER and Embryonic Tissue
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