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DGAT2 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247527

MBS247527 is an antibody targeting DGAT2. Also known as Goat Polyclonal to Human DGAT2. Reactive in Bat, Gibbon, Dog, Gorilla, Horse, Human, Pig, RabbitPredicted Reactivity: Monkey, Mouse, Rat, Hamster (at least 90% immunogen sequence identity). Host: Goat. More details

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Product Overview

Product Name
DGAT2, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human DGAT2
Product Gene Name
anti-DGAT2 antibody
Product Synonym Names
Anti-DGAT2 Antibody (Internal) IHC-plus; DGAT2; ARAT; Diglyceride acyltransferase 2; GS1999FULL; HMFN1045; Human DGAT2
Clonality
Polyclonal
Host
Goat
Species Reactivity
Bat, Gibbon, Dog, Gorilla, Horse, Human, Pig, Rabbit
Predicted Reactivity: Monkey, Mouse, Rat, Hamster (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human DGAT2. This antibody is not expected to cross-react with other DGAT members.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
39,044 Da
OMIM
606983
3D Structure
ModBase 3D Structure for Q96PD7
Target Species
Human
Immunogen Description
Synthetic peptide C-KLEHPTQQDIDLYH from an internal region (near the C-terminus) of human DGAT2 (NP_115953.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Panda, Dog, Bat, Horse, Rabbit, Pig (100%).
Immunogen Type
Synthetic peptide
Immunogen
DGAT2 antibody was raised against synthetic peptide C-KLEHPTQQDIDLYH from an internal region (near the C-terminus) of human DGAT2 (NP_115953.2). Percent identity by BLAST analysis: Human, Gorilla, Gibbon, Marmoset, Panda, Dog, Bat, Horse, Rabbit, Pig (100%); Monkey, Mouse, Rat, Hamster (93%); Bovine, Opossum (86%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-DGAT2 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-DGAT2 antibody
ELISA (1:128000), IHC-P (3.75 ug/ml), WB (0.3 - 1 ug/ml)

Immunohistochemistry (IHC) of anti-DGAT2 antibody

Anti-DGAT2 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-DGAT2 Polyclonal Antibody – Cat# MBS247527

Western Blot (WB) of anti-DGAT2 antibody

Staining (0.5 ug/ml) of Human Liver lysate in the third lane (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
Goat Anti-DGAT2 Polyclonal Antibody, Western Blot (WB) – Cat# MBS247527

Other Notes

Small volumes of anti-DGAT2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for DGAT2. It may not necessarily be applicable to this product.

NCBI GI #
359806523
NCBI GeneID
84649
NCBI Accession #
NP_001240820.1
UniProt Primary Accession #
Q96PD7
UniProt Secondary Accession #
Q5U810; Q68CL3; Q68DJ0; Q8NDB7; Q96BS0; Q9BYE5; A6ND76
UniProt Related Accession #
Q96PD7
GenBank Nucleotide #
NM_001253891.1
NCBI Official Full Name
diacylglycerol O-acyltransferase 2 isoform 2
NCBI Official Synonym Full Names
diacylglycerol O-acyltransferase 2
NCBI Official Symbol
DGAT2
NCBI Official Synonym Symbols
ARAT; HMFN1045; GS1999FULL
UniProt Protein Name
Diacylglycerol O-acyltransferase 2
UniProt Synonym Protein Names
Acyl-CoA retinol O-fatty-acyltransferase (EC:2.3.1.76); ARAT; Retinol O-fatty-acyltransferase; Diglyceride acyltransferase 2
Protein Family
Diacylglycerol O-acyltransferase
UniProt Gene Name
DGAT2
UniProt Synonym Gene Names
ARAT; Retinol O-fatty-acyltransferase
UniProt Entry Name
DGAT2_HUMAN
NCBI Protein Information
diacylglycerol O-acyltransferase 2; diglyceride acyltransferase 2; retinol O-fatty-acyltransferase; acyl-CoA retinol O-fatty-acyltransferase; diacylglycerol O-acyltransferase homolog 2; diacylglycerol O-acyltransferase-like protein 2

NCBI Summary for DGAT2

This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
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UniProt Comments for DGAT2

DGAT2: Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT). Belongs to the diacylglycerol acyltransferase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, multi-pass; Lipid Metabolism - glycerolipid; EC 2.3.1.20; EC 2.3.1.76; Transferase; Cofactor and Vitamin Metabolism - retinol; Membrane protein, integral

Chromosomal Location of Human Ortholog: 11q13.5

Cellular Component: endoplasmic reticulum membrane; mitochondrion; endoplasmic reticulum; perinuclear region of cytoplasm; integral to membrane; integral to endoplasmic reticulum membrane; lipid particle

Molecular Function: 2-acylglycerol O-acyltransferase activity; protein homodimerization activity; retinol O-fatty-acyltransferase activity; diacylglycerol O-acyltransferase activity

Biological Process: sequestering of lipid; cholesterol homeostasis; retinol metabolic process; glycerol metabolic process; fatty acid homeostasis; phospholipid metabolic process; glycerophospholipid biosynthetic process; triacylglycerol biosynthetic process; diacylglycerol metabolic process; cellular lipid metabolic process
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Research Articles on DGAT2

1. DGAT2 is regulated by gp78-associated endoplasmic-reticulum-associated degradation at the post-translational level.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-DGAT2 antibody

 Reference Product  PubMed Publications
 DGAT1 antibody  >102 publications with DGAT2 and DGAT1
 PNPLA2 antibody  >2 publications with DGAT2 and PNPLA2
 PNPLA3 antibody  >1 publications with DGAT2 and PNPLA3
 LPIN1 antibody  >1 publications with DGAT2 and LPIN1

Pathways associated with anti-DGAT2 antibody

 Products by Pathway  Pathway Diagram
 Acyl Chain Remodeling Of DAG And TAG Pathway antibodies  Acyl Chain Remodeling Of DAG And TAG Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fat Digestion And Absorption Pathway antibodies  Fat Digestion And Absorption Pathway Diagram
 Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway antibodies  Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerolipid Metabolism Pathway antibodies  Glycerolipid Metabolism Pathway Diagram
 Glycerophospholipid Biosynthesis Pathway antibodies  Glycerophospholipid Biosynthesis Pathway Diagram
 Metabolic Pathways antibodies  Metabolic Pathways Diagram
 Metabolism Pathway antibodies  Metabolism Pathway Diagram
 Metabolism Of Lipids And Lipoproteins Pathway antibodies  Metabolism Of Lipids And Lipoproteins Pathway Diagram

Diseases associated with anti-DGAT2 antibody

 Disease Name  Pubmed Publications
 Fatty Liver Antibodies  >58 publications with DGAT2 and Fatty Liver
 Liver Diseases Antibodies  >37 publications with DGAT2 and Liver Diseases
 Insulin Resistance Antibodies  >35 publications with DGAT2 and Insulin Resistance
 Inflammation Antibodies  >13 publications with DGAT2 and Inflammation
 Non-alcoholic Fatty Liver Disease Antibodies  >10 publications with DGAT2 and Non-alcoholic Fatty Liver Disease
 Hypertriglyceridemia Antibodies  >9 publications with DGAT2 and Hypertriglyceridemia
 Atherosclerosis Antibodies  >9 publications with DGAT2 and Atherosclerosis
 Dyslipidemias Antibodies  >9 publications with DGAT2 and Dyslipidemias
 Hyperlipidemias Antibodies  >8 publications with DGAT2 and Hyperlipidemias
 Weight Gain Antibodies  >6 publications with DGAT2 and Weight Gain

Organs/Tissues associated with anti-DGAT2 antibody

 Organ/Tissue Name  Pubmed Publications
 Liver Antibodies  >73 publications with DGAT2 and Liver
 Blood Antibodies  >44 publications with DGAT2 and Blood
 Adipose Tissue Antibodies  >42 publications with DGAT2 and Adipose Tissue
 Connective Tissue Antibodies  >26 publications with DGAT2 and Connective Tissue
 Muscle Antibodies  >17 publications with DGAT2 and Muscle
 Heart Antibodies  >12 publications with DGAT2 and Heart
 Intestine Antibodies  >10 publications with DGAT2 and Intestine
 Kidney Antibodies  >6 publications with DGAT2 and Kidney
 Skin Antibodies  >6 publications with DGAT2 and Skin
 Thyroid Antibodies  >4 publications with DGAT2 and Thyroid
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