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P2RX3 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247557

MBS247557 is an antibody targeting P2RX3. Also known as Rabbit Polyclonal to Human P2RX3 / P2X3. Reactive in Gibbon, Gorilla, Human, MonkeyPredicted Reactivity: Bat, Rabbit (at least 90% immunogen sequence identity). Host: Rabbit. More details

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Product Overview

Online Datasheet in PDF
Product Name
P2RX3 / P2X3, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human P2RX3 / P2X3
Product Gene Name
anti-P2RX3 antibody
Product Synonym Gene Name
P2X3
Product Synonym Names
Anti-P2RX3 / P2X3 Antibody (C-Terminus) IHC-plus; P2RX3; ATP receptor; p2X3; p2X3 purinoceptor; p2X purinoceptor 3; Purinergic receptor P2X3; Purinoceptor P2X3; Purinergic receptor; p2RX3; p2X receptor 3; p2X receptor; subunit 3; Human P2RX3; P2X3
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human, Monkey
Predicted Reactivity: Bat, Rabbit (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human P2RX3 / P2X3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
44,289 Da
OMIM
600843
3D Structure
ModBase 3D Structure for P56373
Target Species
Human
Immunogen Description
Synthetic 15 amino acid peptide from C-terminal cytoplasmic domain of human P2RX3 / P2X3. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Bat, Rabbit, Opossum (93%); Mouse, Rat, Hamster.
Immunogen Type
Synthetic peptide
Immunogen
P2RX3 / P2X3 antibody was raised against synthetic 15 amino acid peptide from C-terminal cytoplasmic domain of human P2RX3 / P2X3. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset (100%); Bat, Rabbit, Opossum (93%); Mouse, Rat, Hamster, Elephant, Panda, Bovine, Dog, Horse (87%).
Antigen Modification
C-Terminus

Product Categories/Family for anti-P2RX3 antibody

Family: Ion Channel; Subfamily: P2X receptor
Applications Tested/Suitable for anti-P2RX3 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-P2RX3 antibody
IHC-P (10 ug/ml)
Usage: Antigen retrieval requires Proteinase K treatment.

Immunohistochemistry (IHC) of anti-P2RX3 antibody

Anti-P2RX3 / P2X3 antibody IHC of human prostate. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-P2RX3 Polyclonal Antibody – Cat# MBS247557

Immunohistochemistry (IHC) of anti-P2RX3 antibody

Anti-P2RX3 / P2X3 antibody IHC of human pancreas. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-P2RX3 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247557

Other Notes

Small volumes of anti-P2RX3 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for P2RX3. It may not necessarily be applicable to this product.

NCBI GI #
28416925
NCBI GeneID
5024
NCBI Accession #
NP_002550.2
UniProt Primary Accession #
P56373
UniProt Secondary Accession #
Q6DK37; Q9UQB6
UniProt Related Accession #
P56373
GenBank Nucleotide #
NM_002559.3
NCBI Official Full Name
P2X purinoceptor 3
NCBI Official Synonym Full Names
purinergic receptor P2X, ligand-gated ion channel, 3
NCBI Official Symbol
P2RX3
NCBI Official Synonym Symbols
P2X3
UniProt Protein Name
P2X purinoceptor 3
UniProt Synonym Protein Names
ATP receptor; Purinergic receptor
Protein Family
P2X purinoceptor
UniProt Gene Name
P2RX3
UniProt Synonym Gene Names
P2X3
UniProt Entry Name
P2RX3_HUMAN
NCBI Protein Information
P2X purinoceptor 3; ATP receptor; purinoceptor P2X3; P2X receptor, subunit 3; purinergic receptor P2X3

NCBI Summary for P2RX3

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disorders of urine storage. [provided by RefSeq, Jul 2008]
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UniProt Comments for P2RX3

P2X3: Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family.

Protein type: Channel, ligand-gated; Membrane protein, integral; Membrane protein, multi-pass

Chromosomal Location of Human Ortholog: 11q12

Cellular Component: Golgi apparatus; rough endoplasmic reticulum; cell soma; integral to plasma membrane; dendritic spine; terminal button; integral to nuclear inner membrane; receptor complex; lipid raft

Molecular Function: purinergic nucleotide receptor activity; ATP binding; ATP-gated cation channel activity

Biological Process: urinary bladder smooth muscle contraction; peristalsis; sensory perception of taste; generation of action potential; regulation of synaptic plasticity; positive regulation of calcium-mediated signaling; signal transduction; response to ATP; response to carbohydrate stimulus; behavioral response to pain; response to mechanical stimulus; response to heat; transport; response to hypoxia; neuromuscular synaptic transmission; response to cold; protein homooligomerization
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Research Articles on P2RX3

1. Data indicate that Markov models are suitable to simulate agonist antagonist interactions at fast desensitizing receptors such as the P2X3R.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-P2RX3 antibody

 Reference Product  PubMed Publications
 P2RX2 antibody  >111 publications with P2RX3 and P2RX2
 TRPV1 antibody  >17 publications with P2RX3 and TRPV1
 GDNF antibody  >9 publications with P2RX3 and GDNF
 TAC1 antibody  >1 publications with P2RX3 and TAC1
 P2RY2 antibody  >1 publications with P2RX3 and P2RY2

Pathways associated with anti-P2RX3 antibody

 Products by Pathway  Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Calcium Signaling Pathway antibodies  Calcium Signaling Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram
 Neuroactive Ligand-receptor Interaction Pathway antibodies  Neuroactive Ligand-receptor Interaction Pathway Diagram

Diseases associated with anti-P2RX3 antibody

 Disease Name  Pubmed Publications
 Pain Antibodies  >127 publications with P2RX3 and Pain
 Hyperalgesia Antibodies  >32 publications with P2RX3 and Hyperalgesia
 Disease Models, Animal Antibodies  >30 publications with P2RX3 and Disease Models, Animal
 Inflammation Antibodies  >25 publications with P2RX3 and Inflammation
 Drug Hypersensitivity Antibodies  >4 publications with P2RX3 and Drug Hypersensitivity
 Heart Diseases Antibodies  >4 publications with P2RX3 and Heart Diseases
 Hypertension Antibodies  >2 publications with P2RX3 and Hypertension
 Necrosis Antibodies  >2 publications with P2RX3 and Necrosis
 Headache Antibodies  >1 publications with P2RX3 and Headache
 Hypertrophy Antibodies  >1 publications with P2RX3 and Hypertrophy

Organs/Tissues associated with anti-P2RX3 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >47 publications with P2RX3 and Brain
 Embryonic Tissue Antibodies  >7 publications with P2RX3 and Embryonic Tissue
 Heart Antibodies  >3 publications with P2RX3 and Heart
 Testis Antibodies  >1 publications with P2RX3 and Testis
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