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PTHR2 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247569

PTHR2, a Parathyroid Hormone Receptor, binds parathyroid hormone (PTH), parathyroid hormone-related peptide, and tuberoinfundibular peptide 39 (TIP39). However, parathyroid hormone-related peptide does not activate the receptor. The physiologic role of PTHR2… More details

$630 / 0.05 mg +1 FREE 8GB USB
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Product Overview

Online Datasheet in PDF
Product Name
PTHR2 / PTH2R, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human PTHR2 / PTH2R
Product Gene Name
Product Synonym Gene Name
PTH2R
Product Synonym Names
Anti-PTHR2 / PTH2R Antibody (C-Terminus) IHC-plus; PTH2R; Parathyroid hormone 2 receptor; Parathyroid hormone receptor 2; PTH2 receptor; PTHR2; Hpth2 receptor; Human PTHR2; PTH2R
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Gibbon, Gorilla, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human PTH2R / PTHR2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
62,236 Da
OMIM
601469
3D Structure
ModBase 3D Structure for P49190
Target Species
Human
Immunogen Description
Synthetic 17 amino acid peptide from C-terminus of human PTH2R / PTHR2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (94%); Marmoset (88%); Bovine, Panda (82%).
Immunogen Type
Synthetic peptide
Immunogen
PTHR2 / PTH2R antibody was raised against synthetic 17 amino acid peptide from C-terminus of human PTH2R / PTHR2. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon (100%); Monkey (94%); Marmoset (88%); Bovine, Panda (82%).
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-PTHR2 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-PTHR2 antibody
IHC-P (11 - 28 ug/ml)

Immunohistochemistry (IHC) of anti-PTHR2 antibody

Anti-PTH2R / PTHR2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-PTHR2 Polyclonal Antibody – Cat# MBS247569

Other Notes

Small volumes of anti-PTHR2 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PTHR2 purchase

MBS247569 is an antibody targeting PTHR2. Also known as Rabbit Polyclonal to Human PTHR2 / PTH2R. Reactive in Gibbon, Gorilla, Human
Predicted Reactivity: Monkey (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for PTHR2. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
parathyroid hormone 2 receptor
NCBI Official Synonym Full Names
parathyroid hormone 2 receptor
NCBI Official Symbol
PTH2R
NCBI Official Synonym Symbols
PTHR2
UniProt Protein Name
Parathyroid hormone 2 receptor
UniProt Gene Name
PTH2R
UniProt Synonym Gene Names
PTHR2; PTH2 receptor
UniProt Entry Name
PTH2R_HUMAN
NCBI Protein Information
parathyroid hormone 2 receptor; PTH2 receptor; parathyroid hormone receptor 2

NCBI Summary for PTHR2

The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
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UniProt Comments for PTHR2

PTH2R: This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor. Belongs to the G-protein coupled receptor 2 family.

Protein type: Membrane protein, multi-pass; GPCR, family 2; Receptor, GPCR; Membrane protein, integral

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: parathyroid hormone receptor activity

Biological Process: G-protein coupled receptor protein signaling pathway
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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