ADD1 Antibody – Rabbit Polyclonal

Adducins are a family of cytoskeleton proteins encoded by three genes (alpha, beta, gamma). Adducin is a heterodimeric protein that consists of related subunits, which are produced from distinct genes but share a similar structure. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. In contrast, beta-adducin is expressed at high levels in brain and hematopoietic tissues. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Alternative splicing results in multiple variants encoding distinct isoforms; however, not all variants have been fully described. [provided by RefSeq, Jul 2008]

ADD1: a cytoskeletal protein that promotes the assembly of the spectrin-actin network. Adducin is a heterodimeric protein that consists of related subunits. Alpha- and beta-adducin include a protease-resistant N-terminal region and a protease-sensitive, hydrophilic C-terminal region. Alpha- and gamma-adducins are ubiquitously expressed. Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinases A and C. Three alternatively-spliced isoforms have been described.

Protein type: Motility/polarity/chemotaxis; Cytoskeletal

Chromosomal Location of Human Ortholog: 4p16.3

Cellular Component: nucleoplasm; F-actin capping protein complex; intermediate filament cytoskeleton; focal adhesion; perinuclear region of cytoplasm; postsynaptic density; dendritic spine; plasma membrane; cytosol; nucleus

Molecular Function: actin filament binding; calmodulin binding; protein homodimerization activity; spectrin binding; protein heterodimerization activity; T cell receptor binding; actin binding; structural molecule activity; transcription factor binding

Biological Process: actin filament bundle formation; positive regulation of protein binding; hemoglobin metabolic process; in utero embryonic development; unfolded protein response; apoptosis; multicellular organism growth; cell morphogenesis; positive regulation of endocytosis; positive regulation of angiogenesis; cellular protein metabolic process; unfolded protein response, activation of signaling protein activity; homeostasis of number of cells within a tissue; erythrocyte differentiation; barbed-end actin filament capping; cell volume homeostasis; actin cytoskeleton organization and biogenesis; cell structure disassembly during apoptosis

Disease: Hypertension, Essential