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PAEL Receptor / GPR37 (GPR37) Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247579

GPR37 is an Orphan-A GPCR with an unknown ligand. GPR37 was recently identified as the PAEL receptor, a Parkin substrate involved in autosomal recessive juvenile Parkinson's (PDJ) disease. The PAEL receptor becomes unfolded, insoluble, and ubiquitinated when… More details

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Product Overview

Product Name
PAEL Receptor / GPR37, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human PAEL Receptor / GPR37
Product Gene Name
anti-GPR37 antibody
Product Synonym Names
Anti-PAEL Receptor / GPR37 Antibody (N-Terminus) IHC-plus; GPR37; EDNRBL; ETBR-LP-1; Gpcr/cns1; HET(B)R-LP; Het-b-r-lp; PAELR; Pael receptor; Human PAEL Receptor; GPR37
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human
Predicted Reactivity: Gorilla, Gibbon, Monkey, Rat, Hamster, Rabbit (at least 90% immunogen sequence identity)
Form/Format
PBS, 0.1% sodium azide.
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human GPR37. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Preparation and Storage
Long term: -70 degree C; Short term: +4 degree C
Molecular Weight
67,114 Da
OMIM
602583
3D Structure
ModBase 3D Structure for O15354
Target Species
Human
Immunogen Description
Synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPR37. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rat, Elephant (95%); Hamster, Rabbit (90%); Mouse, Horse (85%).
Immunogen Type
Synthetic peptide
Immunogen
PAEL Receptor / GPR37 antibody was raised against synthetic 20 amino acid peptide from N-terminal extracellular domain of human GPR37. Percent identity with other species by BLAST analysis: Human, Gorilla, Gibbon, Monkey, Marmoset, Rat, Elephant (95%); Hamster, Rabbit (90%); Mouse, Horse (85%).
Antigen Modification
N-Terminus

Product Categories/Family for anti-GPR37 antibody

Family: GPCR; Subfamily: Orphan-A
Applications Tested/Suitable for anti-GPR37 antibody
Immunohistochemistry (IHC - Paraffin)
Application Notes for anti-GPR37 antibody
IHC-P (1 ug/ml)

Immunohistochemistry (IHC) of anti-GPR37 antibody

Anti-PAEL Receptor / GPR37 antibody IHC of human Ovary, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GPR37 Polyclonal Antibody – Cat# MBS247579

Immunohistochemistry (IHC) of anti-GPR37 antibody

Anti-PAEL Receptor / GPR37 antibody IHC of human Colon, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GPR37 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247579

Immunohistochemistry (IHC) of anti-GPR37 antibody

Anti-PAEL Receptor / GPR37 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GPR37 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247579

Immunohistochemistry (IHC) of anti-GPR37 antibody

Anti-GPR37 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.
Rabbit Anti-GPR37 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247579

Other Notes

Small volumes of anti-GPR37 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GPR37 purchase

MBS247579 is an antibody targeting GPR37. Also known as Rabbit Polyclonal to Human PAEL Receptor / GPR37. Reactive in Human
Predicted Reactivity: Gorilla, Gibbon, Monkey, Rat, Hamster, Rabbit (at least 90% immunogen sequence identity). Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for GPR37. It may not necessarily be applicable to this product.

NCBI GI #
4885323
NCBI GeneID
2861
NCBI Accession #
NP_005293.1
UniProt Primary Accession #
O15354
UniProt Secondary Accession #
O00348; O14768; Q8TD39; A4D0Y6
UniProt Related Accession #
O15354
GenBank Nucleotide #
NM_005302.3
NCBI Official Full Name
prosaposin receptor GPR37
NCBI Official Synonym Full Names
G protein-coupled receptor 37 (endothelin receptor type B-like)
NCBI Official Symbol
GPR37
NCBI Official Synonym Symbols
PAELR; EDNRBL; hET(B)R-LP
UniProt Protein Name
Prosaposin receptor GPR37
UniProt Synonym Protein Names
Endothelin B receptor-like protein 1; ETBR-LP-1; G-protein coupled receptor 37; Parkin-associated endothelin receptor-like receptor; PAELR
Protein Family
Prosaposin receptor
UniProt Gene Name
GPR37
UniProt Synonym Gene Names
ETBR-LP-1; PAELR
UniProt Entry Name
GPR37_HUMAN
NCBI Protein Information
prosaposin receptor GPR37; ETBR-LP-1; G-protein coupled receptor 37; endothelin B receptor-like protein 1; probable G-protein coupled receptor 37; Parkin-associated endothelin receptor-like receptor

NCBI Summary for GPR37

This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]
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UniProt Comments for GPR37

GPR37: Orphan receptor. May have a unique functional role in the central nervous system. Belongs to the G-protein coupled receptor 1 family.

Protein type: Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; GPCR, family 1

Chromosomal Location of Human Ortholog: 7q31

Cellular Component: endoplasmic reticulum membrane; integral to plasma membrane; plasma membrane; receptor complex; ubiquitin ligase complex

Molecular Function: G-protein coupled receptor activity; protein binding; heat shock protein binding; ubiquitin protein ligase binding; peptide receptor activity, G-protein coupled; Hsp70 protein binding; peptide binding

Biological Process: G-protein coupled receptor protein signaling pathway; positive regulation of dopamine metabolic process; positive regulation of MAPKKK cascade; dopamine biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; locomotion during locomotory behavior
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Research Articles on GPR37

1. Positive role of GPR37 in the proliferation of multiple myeloma cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-GPR37 antibody

 Reference Product  PubMed Publications
 PARK2 antibody  >21 publications with GPR37 and PARK2
 SYVN1 antibody  >4 publications with GPR37 and SYVN1

Pathways associated with anti-GPR37 antibody

 Products by Pathway  Pathway Diagram
 Class A/1 (Rhodopsin-like Receptors) Pathway antibodies  Class A/1 (Rhodopsin-like Receptors) Pathway Diagram
 Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway antibodies  Defective ACTH Causes Obesity And Pro-opiomelanocortinin Deficiency (POMCD) Pathway Diagram
 Disease Pathway antibodies  Disease Pathway Diagram
 GPCR Ligand Binding Pathway antibodies  GPCR Ligand Binding Pathway Diagram
 GPCRs, Class A Rhodopsin-like Pathway antibodies  GPCRs, Class A Rhodopsin-like Pathway Diagram
 Metabolic Disorders Of Biological Oxidation Enzymes Pathway antibodies  Metabolic Disorders Of Biological Oxidation Enzymes Pathway Diagram
 Parkin-Ubiquitin Proteasomal System Pathway antibodies  Parkin-Ubiquitin Proteasomal System Pathway Diagram
 Parkinson's Disease Pathway antibodies  Parkinson's Disease Pathway Diagram
 Parkinsons Disease Pathway antibodies  Parkinsons Disease Pathway Diagram
 Peptide Ligand-binding Receptors Pathway antibodies  Peptide Ligand-binding Receptors Pathway Diagram

Diseases associated with anti-GPR37 antibody

 Disease Name  Pubmed Publications
 Nervous System Diseases Antibodies  >19 publications with GPR37 and Nervous System Diseases
 Nerve Degeneration Antibodies  >3 publications with GPR37 and Nerve Degeneration
 Disease Models, Animal Antibodies  >2 publications with GPR37 and Disease Models, Animal
 Multiple Myeloma Antibodies  >1 publications with GPR37 and Multiple Myeloma
 Atrophy Antibodies  >1 publications with GPR37 and Atrophy
 Liver Diseases Antibodies  >1 publications with GPR37 and Liver Diseases
 Fibrosis Antibodies  >1 publications with GPR37 and Fibrosis

Organs/Tissues associated with anti-GPR37 antibody

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >26 publications with GPR37 and Brain
 Testis Antibodies  >1 publications with GPR37 and Testis
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