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HSPB1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247589

The protein encoded by this gene is induced by environmental stress and developmental changes. The encoded protein is involved in stress resistance and actin organization and translocates from the cytoplasm to the nucleus upon stress induction. Defects in… More details

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Product Overview

Product Name
HSPB1 / HSP27, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal (IgG) to Human HSPB1 / HSP27
Product Gene Name
anti-HSPB1 antibody
Product Synonym Gene Name
HSP27
Product Synonym Names
Anti-HSPB1 / HSP27 Antibody (aa45-94) IHC-plus; HSPB1; 28 kDa heat shock protein; Heat shock 27 kDa protein; Heat shock 27kD protein 1; Heat shock 27kDa protein 1; HSP27; HSP28; HSP 27; Hsp25; SRP27; Stress-responsive protein 27; CMT2F; Heat shock 27 kd protein; Heat shock protein beta-1; HMN2B; Human HSPB1; HSP27
Clonality
Polyclonal
Isotype
IgG
Host
Rabbit
Species Reactivity
Human
Form/Format
PBS (without Mg2+, Ca2+), pH 7.4, 150 mM sodium chloride, 0.02% sodium azide, 50% glycerol
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
HSP27 (Ab-78) Antibody detects endogenous levels of total HSP27 protein.
Preparation and Storage
Store at -20 degree C for up to one year.
Molecular Weight
22,783 Da
OMIM
phenotype 608634
3D Structure
ModBase 3D Structure for P04792
Target Species
Human
Immunogen Description
Synthetic peptide from human HSP27 (aa45-94).
Immunogen
HSPB1 / HSP27 antibody was raised against synthetic peptide from human HSP27 (aa45-94).
Antigen Modification
aa45-94
Applications Tested/Suitable for anti-HSPB1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-HSPB1 antibody
ELISA (1:20000), IHC-P (10 ug/ml), WB (1:500 - 1:1000)

Immunohistochemistry (IHC) of anti-HSPB1 antibody

Anti-HSPB1 antibody IHC of human skeletal muscle. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-HSPB1 Polyclonal Antibody – Cat# MBS247589

Immunohistochemistry (IHC) of anti-HSPB1 antibody

Anti-HSPB1 antibody IHC of human skin. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-HSPB1 Polyclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS247589

Western Blot (WB) of anti-HSPB1 antibody

Western blot of extracts from Jurkat cells, treated with Ca2+, using HSP27 (Ab-78) Antibody. The lane on the right is treated with the synthesized peptide.
Rabbit Anti-HSPB1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS247589

Other Notes

Small volumes of anti-HSPB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for HSPB1 purchase

MBS247589 is an antibody targeting HSPB1. Also known as Rabbit Polyclonal (IgG) to Human HSPB1 / HSP27. Reactive in Human. Host: Rabbit.

Additional Details

NCBI/Uniprot data below describe general gene information for HSPB1. It may not necessarily be applicable to this product.

NCBI GI #
4504517
NCBI GeneID
3315
NCBI Accession #
NP_001531.1
UniProt Primary Accession #
P04792
UniProt Secondary Accession #
Q6FI47; Q96C20; Q96EI7; Q9UC31; Q9UC34; Q9UC35; Q9UC36; B2R4N8
UniProt Related Accession #
P04792
GenBank Nucleotide #
NM_001540.3
NCBI Official Full Name
heat shock protein beta-1
NCBI Official Synonym Full Names
heat shock 27kDa protein 1
NCBI Official Symbol
HSPB1
NCBI Official Synonym Symbols
CMT2F; HMN2B; HSP27; HSP28; Hsp25; SRP27; HS.76067; HEL-S-102
UniProt Protein Name
Heat shock protein beta-1
UniProt Synonym Protein Names
28 kDa heat shock protein; Estrogen-regulated 24 kDa protein; Heat shock 27 kDa protein; HSP 27; Stress-responsive protein 27; SRP27
Protein Family
Heat shock protein
UniProt Gene Name
HSPB1
UniProt Synonym Gene Names
HSP27; HSP28; HspB1; HSP 27; SRP27
UniProt Entry Name
HSPB1_HUMAN
NCBI Protein Information
heat shock protein beta-1; HSP 27; 28 kDa heat shock protein; heat shock 27 kDa protein; heat shock 27kD protein 1; stress-responsive protein 27; estrogen-regulated 24 kDa protein; epididymis secretory protein Li 102

UniProt Comments for HSPB1

HSP27: a small heat shock protein that is regulated both transcriptionally and posttranslationally. Modulates actin polymerization and reorganization. Its expression level increases several-fold in response to stress and is phosphorylated by MAPKAP kinase 2. Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock.

Protein type: Motility/polarity/chemotaxis; Heat shock protein; Chaperone

Chromosomal Location of Human Ortholog: 7q11.23

Cellular Component: proteasome complex; extracellular space; cytoskeleton; focal adhesion; cytoplasm; plasma membrane; spindle; Z disc; cytosol; nucleus

Molecular Function: protein kinase C inhibitor activity; identical protein binding; ubiquitin binding; protein binding; protein kinase C binding; protein kinase binding

Biological Process: positive regulation of tumor necrosis factor biosynthetic process; response to virus; positive regulation of blood vessel endothelial cell migration; response to unfolded protein; retinal homeostasis; positive regulation of interleukin-1 beta production; positive regulation of angiogenesis; negative regulation of protein kinase activity; gene expression; cell motility; vascular endothelial growth factor receptor signaling pathway; regulation of I-kappaB kinase/NF-kappaB cascade; regulation of translational initiation; negative regulation of apoptosis

Disease: Neuronopathy, Distal Hereditary Motor, Type Iib; Charcot-marie-tooth Disease, Axonal, Type 2f
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Research Articles on HSPB1

1. Hsp27 protein was found to be commonly expressed in cervical epithelial cells.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Pathways associated with anti-HSPB1 antibody

 Products by Pathway  Pathway Diagram
 AUF1 (hnRNP D0) Destabilizes MRNA Pathway antibodies  AUF1 (hnRNP D0) Destabilizes MRNA Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Amoebiasis Pathway antibodies  Amoebiasis Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 Epstein-Barr Virus Infection Pathway antibodies  Epstein-Barr Virus Infection Pathway Diagram
 FAS Pathway And Stress Induction Of HSP Regulation antibodies  FAS Pathway And Stress Induction Of HSP Regulation Diagram
 Gene Expression Pathway antibodies  Gene Expression Pathway Diagram
 IL-3 Signaling Pathway antibodies  IL-3 Signaling Pathway Diagram
 IL-6 Signaling Pathway antibodies  IL-6 Signaling Pathway Diagram
 MAPK Signaling Pathway antibodies  MAPK Signaling Pathway Diagram

Diseases associated with anti-HSPB1 antibody

 Disease Name  Pubmed Publications
 Cardiovascular Diseases Antibodies  >121 publications with HSPB1 and Cardiovascular Diseases
 Disease Models, Animal Antibodies  >94 publications with HSPB1 and Disease Models, Animal
 Necrosis Antibodies  >69 publications with HSPB1 and Necrosis
 Inflammation Antibodies  >66 publications with HSPB1 and Inflammation
 Breast Neoplasms Antibodies  >61 publications with HSPB1 and Breast Neoplasms
 Heart Diseases Antibodies  >60 publications with HSPB1 and Heart Diseases
 Liver Diseases Antibodies  >42 publications with HSPB1 and Liver Diseases
 Reperfusion Injury Antibodies  >35 publications with HSPB1 and Reperfusion Injury
 Kidney Diseases Antibodies  >31 publications with HSPB1 and Kidney Diseases
 Lung Neoplasms Antibodies  >30 publications with HSPB1 and Lung Neoplasms

Organs/Tissues associated with anti-HSPB1 antibody

 Organ/Tissue Name  Pubmed Publications
 Muscle Antibodies  >229 publications with HSPB1 and Muscle
 Blood Antibodies  >155 publications with HSPB1 and Blood
 Brain Antibodies  >154 publications with HSPB1 and Brain
 Heart Antibodies  >115 publications with HSPB1 and Heart
 Nerve Antibodies  >109 publications with HSPB1 and Nerve
 Vascular Antibodies  >97 publications with HSPB1 and Vascular
 Liver Antibodies  >81 publications with HSPB1 and Liver
 Lung Antibodies  >72 publications with HSPB1 and Lung
 Kidney Antibodies  >72 publications with HSPB1 and Kidney
 Skin Antibodies  >44 publications with HSPB1 and Skin
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