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ZCRB1 Antibody – Rabbit Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247667

MBS247667 is an antibody targeting ZCRB1. Also known as Rabbit Polyclonal to Human ZCRB1. Reactive in Human, Mouse, Rat. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
ZCRB1, Polyclonal Antibody
Full Product Name
Rabbit Polyclonal to Human ZCRB1
Product Gene Name
Product Synonym Names
Anti-ZCRB1 Antibody (C-Terminus) IHC-plus; ZCRB1; SNRNP31; ZCCHC19; U11/U12 snRNP 31K; RBM36; MADP-1; MADP1; U11/U12 snRNP 31 kDa protein; U11/U12-31K; Human ZCRB1
Clonality
Polyclonal
Host
Rabbit
Species Reactivity
Human, Mouse, Rat
Form/Format
PBS, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
1 mg/ml (lot specific)
Specificity
Human ZCRB1
Preparation and Storage
Short term 4 degree C, long term aliquot and store at -20 degree C, avoid freeze thaw cycles. Store undiluted.
Molecular Weight
24,592 Da
OMIM
610750
3D Structure
ModBase 3D Structure for Q8TBF4
Target Species
Human
Immunogen Description
A 17 amino acid peptide near the carboxy terminus of human ZCRB1.
Immunogen Type
Synthetic peptide
Immunogen
ZCRB1 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human ZCRB1.
Antigen Modification
C-Terminus
Applications Tested/Suitable for anti-ZCRB1 antibody
Immunohistochemistry (IHC - Paraffin), Western Blot (WB), ELISA (EIA)
Application Notes for anti-ZCRB1 antibody
ELISA, IHC-P (10 ug/ml), WB (1 - 2 ug/ml)
Usage: ZCRB1 antibody can be used for detection of ZCRB1 by Western blot at 1-2 ug/ml.

Immunohistochemistry (IHC) of anti-ZCRB1 antibody

Anti-ZCRB1 antibody IHC of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 10 ug/ml.
Rabbit Anti-ZCRB1 Polyclonal Antibody – Cat# MBS247667

Western Blot (WB) of anti-ZCRB1 antibody

Western blot of ZCRB1 in Raji cell lysate with ZCRB1 antibody at (A) 1 and (B) 2 ug/ml.
Rabbit Anti-ZCRB1 Polyclonal Antibody, Western Blot (WB) – Cat# MBS247667

Other Notes

Small volumes of anti-ZCRB1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for ZCRB1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
zinc finger CCHC-type and RNA-binding motif-containing protein 1
NCBI Official Synonym Full Names
zinc finger CCHC-type and RNA binding motif 1
NCBI Official Symbol
ZCRB1
NCBI Official Synonym Symbols
MADP1; RBM36; MADP-1; SNRNP31; ZCCHC19
UniProt Protein Name
Zinc finger CCHC-type and RNA-binding motif-containing protein 1
UniProt Synonym Protein Names
U11/U12 small nuclear ribonucleoprotein 31 kDa protein; U11/U12 snRNP 31 kDa protein; U11/U12-31K
UniProt Gene Name
ZCRB1
UniProt Synonym Gene Names
U11/U12 snRNP 31 kDa protein; U11/U12-31K
UniProt Entry Name
ZCRB1_HUMAN
NCBI Protein Information
zinc finger CCHC-type and RNA-binding motif-containing protein 1; U11/U12-31K; U11/U12 snRNP 31K; U11/U12 snRNP 31 kDa protein; U11/U12 small nuclear ribonucleoprotein 31 kDa protein

NCBI Summary for ZCRB1

Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]
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UniProt Comments for ZCRB1

ZCRB1: Up-regulated by morphine. Down-regulated at 30-36 degrees Celsius while it is up-regulated at 39 degrees Celsius. Component of the U11/U12 snRNPs that are part of the U12- type spliceosome.

Protein type: RNA-binding

Chromosomal Location of Human Ortholog: 12q12

Cellular Component: nucleoplasm; U12-dependent spliceosome

Molecular Function: zinc ion binding; nucleotide binding

Biological Process: RNA splicing; mRNA processing
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Organs/Tissues associated with anti-ZCRB1 antibody

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