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VPS11 Antibody – Goat Polyclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS247701

MBS247701 is an antibody targeting VPS11. Also known as Goat Polyclonal to Human VPS11. Reactive in Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, RatPredicted Reactivity: Xenopus (at least 90% immunogen sequence identity). Host: Goat. More details

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Product Overview

Product Name
VPS11, Polyclonal Antibody
Full Product Name
Goat Polyclonal to Human VPS11
Product Gene Name
Product Synonym Names
Anti-VPS11 Antibody (Internal) IHC-plus; VPS11; END1; HVPS11; PEP5; RING finger protein 108; RNF108; Human VPS11
Clonality
Polyclonal
Host
Goat
Species Reactivity
Bovine, Dog, Gorilla, Hamster, Horse, Human, Monkey, Mouse, Pig, Rat
Predicted Reactivity: Xenopus (at least 90% immunogen sequence identity)
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Purity/Purification
Immunoaffinity Purified
Concentration
0.5 mg/ml (lot specific)
Specificity
Human VPS11.
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.
Molecular Weight
107,837 Da
OMIM
608549
3D Structure
ModBase 3D Structure for Q9H270
Target Species
Human
Immunogen Description
Synthetic peptide C-HALQEKDTQTKLE from an internal region of human VPS11 (NP_068375.3). Percent identity by BLAST analysis: Human, Gorilla, Marmoset, Mouse, Rat, Hamster, Dog, Bovine, Horse, Pig (100%); Opossum, Xenopus (92%).
Immunogen Type
Synthetic peptide
Immunogen
VPS11 antibody was raised against synthetic peptide C-HALQEKDTQTKLE from an internal region of human VPS11 (NP_068375.3). Percent identity by BLAST analysis: Human, Gorilla, Marmoset, Mouse, Rat, Hamster, Dog, Bovine, Horse, Pig (100%); Opossum, Xenopus (92%); Chicken, Medaka, Zebrafish (85%).
Antigen Modification
Internal
Applications Tested/Suitable for anti-VPS11 antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes for anti-VPS11 antibody
ELISA (1:32000), IHC-P (3.75 ug/ml)

Immunohistochemistry (IHC) of anti-VPS11 antibody

Anti-VPS11 antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 3.75 ug/ml.
Goat Anti-VPS11 Polyclonal Antibody – Cat# MBS247701

Other Notes

Small volumes of anti-VPS11 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for VPS11. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
GenBank Nucleotide #
NCBI Official Full Name
vacuolar protein sorting-associated protein 11 homolog isoform 1
NCBI Official Synonym Full Names
vacuolar protein sorting 11 homolog (S. cerevisiae)
NCBI Official Symbol
VPS11
NCBI Official Synonym Symbols
END1; PEP5; RNF108; hVPS11
UniProt Protein Name
Vacuolar protein sorting-associated protein 11 homolog
UniProt Synonym Protein Names
RING finger protein 108
UniProt Gene Name
VPS11
UniProt Synonym Gene Names
RNF108; hVPS11
UniProt Entry Name
VPS11_HUMAN
NCBI Protein Information
vacuolar protein sorting-associated protein 11 homolog; RING finger protein 108

NCBI Summary for VPS11

Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps11 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
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UniProt Comments for VPS11

VPS11: May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. Belongs to the VPS11 family.

Protein type: Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: 11q23

Cellular Component: late endosome membrane; lysosome; endocytic vesicle; lysosomal membrane; late endosome; endosome

Molecular Function: protein binding; syntaxin binding; zinc ion binding; nucleotide binding

Biological Process: vesicle-mediated transport; intracellular protein transport
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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